Search Results - "Kruisbergen, N.N.L."

IL-1β inhibition combined with cholesterol-lowering therapies decreases synovial lining thickness and spontaneous cartilage degeneration in a humanized dyslipidemia mouse model by van Gemert, Y., Kruisbergen, N.N.L., Blom, A.B., van den Bosch, M.H.J., van der Kraan, P.M., Pieterman, E.J., Princen, H.M.G., van Lent, P.L.E.M.

“…Both systemic inflammation and dyslipidemia contribute to osteoarthritis (OA) development and have been suggested as a possible link between metabolic disease…”
Get full text

Novel high-intensive cholesterol-lowering therapies do not ameliorate knee OA development in humanized dyslipidemic mice by van Gemert, Y., Kozijn, A.E., Pouwer, M.G., Kruisbergen, N.N.L., van den Bosch, M.H.J., Blom, A.B., Pieterman, E.J., Weinans, H., Stoop, R., Princen, H.M.G., van Lent, P.L.E.M.

“…High systemic cholesterol levels have been associated with osteoarthritis (OA) development. Therefore, cholesterol lowering by statins has been suggested as a…”
Get full text

Intensive cholesterol-lowering treatment reduces synovial inflammation during early collagenase-induced osteoarthritis, but not pathology at end-stage disease in female dyslipidemic E3L.CETP mice by van Gemert, Y., Blom, A.B., Di Ceglie, I., Walgreen, B., Helsen, M., Sloetjes, A., Vogl, T., Roth, J., Kruisbergen, N.N.L., Pieterman, E.J., Princen, H.M.G., van der Kraan, P.M., van Lent, P.L.E.M., van den Bosch, M.H.J.

“…The association between metabolic syndrome (MetS) and osteoarthritis (OA) development has become increasingly recognized. In this context, the exact role of…”
Get full text

A single dose of anti-IL-1β antibodies prevents Western diet-induced immune activation during early stage collagenase-induced osteoarthritis, but does not ameliorate end-stage pathology by Kruisbergen, N.N.L., van Gemert, Y., Walgreen, B., Helsen, M.M.A., Slöetjes, A.W., Koenders, M.I., van de Loo, F.A.J., Roth, J., Vogl, T., van der Kraan, P.M., Blom, A.B., van den Bosch, M.H.J., van Lent, P.L.E.M.

“…Metabolic dysfunction can cause IL-1β mediated activation of the innate immune system, which could have important implications for the therapeutic efficacy of…”
Get full text

The role of NOX2-derived reactive oxygen species in collagenase-induced osteoarthritis by van Dalen, S.C.M., Kruisbergen, N.N.L., Walgreen, B., Helsen, M.M.A., Slöetjes, A.W., Cremers, N.A.J., Koenders, M.I., van de Loo, F.A.J., Roth, J., Vogl, T., Blom, A.B., van der Kraan, P.M., van Lent, P.L.E.M., van den Bosch, M.H.J.

“…Synovitis in collagenase-induced osteoarthritis (CiOA) is driven by locally released S100A8/A9 proteins and enhances joint destruction. S100A8/A9 can induce…”
Get full text