Search Results - "Kruh, Gary"

The MRP family of drug efflux pumps by Kruh, Gary D, Belinsky, Martin G

“…The MRP family is comprised of nine related ABC transporters that are able to transport structurally diverse lipophilic anions and function as drug efflux…”
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organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis by Rao, Anuradha, Haywood, Jamie, Craddock, Ann L, Belinsky, Martin G, Kruh, Gary D, Dawson, Paul A

“…The apical sodium-dependent bile acid transporter (Asbt) is responsible for transport across the intestinal brush border membrane; however, the carrier(s)…”
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Human Multidrug Resistance Protein 7 (ABCC10) Is a Resistance Factor for Nucleoside Analogues and Epothilone B by HOPPER-BORGE, Elizabeth, XIU XU, TONG SHEN, ZHI SHI, CHEN, Zhe-Sheng, KRUH, Gary D

“…Multidrug resistance protein 7 (MRP7; ABCC10) is an ATP-binding cassette transporter which is able to transport amphipathic anions and confer resistance to…”
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ABCC10, ABCC11, and ABCC12 by Kruh, Gary D, Guo, Yanping, Hopper-Borge, Elizabeth, Belinsky, Martin G, Chen, Zhe-Sheng

“…Multidrug resistance protein (MRP)7, MRP8, and MRP9 (gene symbols ABCC10, ABCC11, and ABCC12) are recently identified members of the MRP family that are at…”
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Predicting drug sensitivity and resistance: Profiling ABC transporter genes in cancer cells by Szakács, Gergely, Annereau, Jean-Philippe, Lababidi, Samir, Shankavaram, Uma, Arciello, Angela, Bussey, Kimberly J., Reinhold, William, Guo, Yanping, Kruh, Gary D., Reimers, Mark, Weinstein, John N., Gottesman, Michael M.

“…For analysis of multidrug resistance, a major barrier to effective cancer chemotherapy, we profiled mRNA expression of the 48 known human ABC transporters in…”
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The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms by Risinger, April L, Jackson, Evelyn M, Polin, Lisa A, Helms, Gregory L, LeBoeuf, Desiree A, Joe, Patrick A, Hopper-Borge, Elizabeth, Ludueña, Richard F, Kruh, Gary D, Mooberry, Susan L

“…The taccalonolides are a class of structurally and mechanistically distinct microtubule-stabilizing agents isolated from Tacca chantrieri. A crucial feature of…”
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Introduction to resistance to anticancer agents by Kruh, Gary D

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MRP8, ATP-binding Cassette C11 (ABCC11), Is a Cyclic Nucleotide Efflux Pump and a Resistance Factor for Fluoropyrimidines 2′,3′-Dideoxycytidine and 9′-(2′-Phosphonylmethoxyethyl)adenine by Guo, Yanping, Kotova, Elena, Chen, Zhe-Sheng, Lee, Kun, Hopper-Borge, Elizabeth, Belinsky, Martin G., Kruh, Gary D.

“…MRP8 (ABCC11) is a recently identified cDNA that has been assigned to the multidrug resistance-associated protein (MRP) family of ATP-binding cassette…”
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Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): Resistance to docetaxel by HOPPER-BORGE, Elizabeth, CHEN, Zhe-Sheng, SHCHAVELEVA, Irina, BELINSKY, Martin G, KRUH, Gary D

“…The multidrug resistance protein (MRP) family consists of nine members that can be categorized according to whether or not a third (NH(2)-terminal)…”
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Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10-/- Mice by HOPPER-BORGE, Elizabeth A, CHURCHILL, Timothy, KLEIN-SZANTO, Andres J, BELINSKY, Martin G, KRUH, Gary D, PAULOSE, Chelsy, NICOLAS, Emmanuelle, JACOBS, Joely D, NGO, Olivia, YEHONG KUANG, GRINBERG, Alex, WESTPHAL, Heiner, CHEN, Zhe-Sheng

“…Recently, we reported that the ATP-binding cassette transporter 10 (ABCC10), also known as multidrug resistance protein 7 (MRP7), is able to confer resistance…”
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Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6) by BELINSKY, Martin G, CHEN, Zhe-Sheng, SHCHAVELEVA, Irina, HAO ZENG, KRUH, Gary D

“…Mutations in human multidrug resistance protein 6 (MRP6, ABCC6), a member of the MRP family of drug efflux pumps, are the genetic basis of Pseudoxanthoma…”
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Predicting Human Tumor Drug Concentrations from a Preclinical Pharmacokinetic Model of Temozolomide Brain Disposition by QINGYU ZHOU, PING GUO, KRUH, Gary D, VICINI, Paolo, XIAOMIN WANG, GALLO, James M

“…Purpose: Knowledge of drug concentrations in tumors is critical for understanding the determinants of drug accumulation in tumors. Because significant…”
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Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice by Kruh, Gary D, Belinsky, Martin G, Gallo, James M, Lee, Kun

“…The MRP family is composed of nine transporters, at least eight of which are lipophilic anion transporters that are capable of conferring resistance to various…”
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Influence of blood-brain barrier efflux pumps on the distribution of vincristine in brain and brain tumors by Wang, Fan, Zhou, Feng, Kruh, Gary D., Gallo, James M.

“…Vincristine (VCR) is efficacious in some but not all brain cancers and an established substrate of Pgp and Mrp1. However, the extent to which such transporters…”
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ArgBP2γ interacts with Akt and p21-activated kinase-1 and promotes cell survival by Yuan, Zeng-qiang, Kim, Donghwa, Kaneko, Satoshi, Sussman, Melissa, Bokoch, Gary M., Kruh, Gary D., Nicosia, Santo V., Testa, Joseph R., Cheng, Jin Q.

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Transport of methotrexate, methotrexate polyglutamates, and 17β-estradiol 17-(β-D-glucuronide) by ABCG2: Effects of acquired mutations at R482 on methotrexate transport by CHEN, Zhe-Sheng, ROBEY, Robert W, BELINSKY, Martin G, SHCHAVELEVA, Irina, REN, Xiao-Qin, SUGIMOTO, Yoshikazu, ROSS, Douglas D, BATES, Susan E, KRUH, Gary D

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Analysis of the in vivo functions of Mrp3 by Belinsky, Martin G, Dawson, Paul A, Shchaveleva, Irina, Bain, Lisa J, Wang, Renxue, Ling, Victor, Chen, Zhe-Sheng, Grinberg, Alex, Westphal, Heiner, Klein-Szanto, Andres, Lerro, Anthony, Kruh, Gary D

“…Multidrug resistance protein 3 (MRP3) is an ATP-binding cassette transporter that is able to confer resistance to anticancer agents such as etoposide and to…”
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Expression of ABCC-Type Nucleotide Exporters in Blasts of Adult Acute Myeloid Leukemia: Relation to Long-term Survival by YANPING GUO, KOCK, Kathleen, EHNINGER, Gerhard, GANDHI, Varsha, KROEMER, Heyo K, KRUH, Gary D, SCHAICH, Markus, RITTER, Christoph A, CHEN, Zhe-Sheng, GRUBE, Markus, JEDLITSCHKY, Gabriele, ILLMER, Thomas, AYRES, Mary, BECK, James F, SIEGMUND, Werner

“…Purpose: Successful treatment of acute myeloid leukemia (AML) remains a therapeutic challenge, with a high percentage of patients suffering from persistent or…”
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Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system by CHEN, Zhe-Sheng, LEE, Kun, WALTHER, Susan, RAFTOGIANIS, Rebecca Blanchard, KUWANO, Michihiko, HAO ZENG, KRUH, Gary D

“…Human MRP4 (ABCC4, MOAT-B) is a lipophilic anion transporter that is able to confer resistance to nucleotide analogues and methotrexate (MTX). We previously…”
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Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11) by Chen, Zhe-Sheng, Guo, Yanping, Belinsky, Martin G, Kotova, Elena, Kruh, Gary D

“…We previously determined that expression of human multidrug resistance protein (MRP) 8, a recently described member of the MRP family of ATP-binding cassette…”
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