Search Results - "Kruh, G"

The MRP family of drug efflux pumps by Kruh, Gary D, Belinsky, Martin G

“…The MRP family is comprised of nine related ABC transporters that are able to transport structurally diverse lipophilic anions and function as drug efflux…”
Get full text

MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver by BELINSKY, M. G, KRUH, G. D

“…Multidrug resistance-associated protein (MRP) and the canalicular multispecific organic anion transporter (cMOAT) are organic anion pumps that have been linked…”
Get full text

Transport of amphipathic anions by human multidrug resistance protein 3 by HAO ZENG, GUOSHENG LIU, REA, Philip A, KRUH, Gary D

“…The multidrug resistance-associated protein 1 (MRP1) and the canalicular multispecific organic anion transporter (cMOAT or MRP2) are ATP-binding cassette…”
Get full text

Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins by BELINSKY, M. G, BAIN, L. J, BALSARA, B. B, TESTA, J. R, KRUH, G. D

“…Multidrug resistance-associated protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are transporter proteins that pump organic anions…”
Get full text

Predicting drug sensitivity and resistance: Profiling ABC transporter genes in cancer cells by Szakács, Gergely, Annereau, Jean-Philippe, Lababidi, Samir, Shankavaram, Uma, Arciello, Angela, Bussey, Kimberly J., Reinhold, William, Guo, Yanping, Kruh, Gary D., Reimers, Mark, Weinstein, John N., Gottesman, Michael M.

“…For analysis of multidrug resistance, a major barrier to effective cancer chemotherapy, we profiled mRNA expression of the 48 known human ABC transporters in…”
Get full text

Expression pattern of MRP in human tissues and adult solid tumor cell lines by Kruh, G D, Gaughan, K T, Godwin, A, Chan, A

Get more information

Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter by KUN LEE, BELINSKY, M. G, BELL, D. W, TESTA, J. R, KRUH, G. D

“…Multidrug resistance-associated protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are closely related mammalian ATP-binding…”
Get full text

Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution by BREUNINGER, L. M, PAUL, S, GAUGHAN, K, MIKI, T, CHAN, A, AAROSON, S. A, KRUH, G. D

“…Multidrug resistance is a major obstacle to cancer treatment. Using an expression cDNA library transfer approach to elucidating the molecular basis of…”
Get full text

MRP8, ATP-binding Cassette C11 (ABCC11), Is a Cyclic Nucleotide Efflux Pump and a Resistance Factor for Fluoropyrimidines 2′,3′-Dideoxycytidine and 9′-(2′-Phosphonylmethoxyethyl)adenine by Guo, Yanping, Kotova, Elena, Chen, Zhe-Sheng, Lee, Kun, Hopper-Borge, Elizabeth, Belinsky, Martin G., Kruh, Gary D.

“…MRP8 (ABCC11) is a recently identified cDNA that has been assigned to the multidrug resistance-associated protein (MRP) family of ATP-binding cassette…”
Get full text

Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: Effect of polyglutamylation on MTX transport by HAO ZENG, CHEN, Zhe-Sheng, BELINSKY, Martin G, REA, Philip A, KRUH, Gary D

“…We have recently determined that human multidrug resistance protein (MRP) 3, which confers resistance to certain natural product agents and methotrexate (MTX),…”
Get full text

Transforming activity and mitosis-related expression of the AKT2 oncogene : evidence suggesting a link between cell cycle regulation and oncogenesis by JIN QUAN CHENG, ALTOMARE, D. A, KLEIN, M. A, LEE, W.-C, KRUH, G. D, LISSY, N. A, TESTA, J. R

“…The AKT2 oncogene encodes a protein-serine/threonine kinase containing a pleckstrin homology domain characteristic of many signaling proteins. Recently, it was…”
Get full text

Analysis of the MRP4 Drug Resistance Profile in Transfected NIH3T3 Cells by Lee, Kun, Klein-Szanto, Andres J. P., Kruh, Gary D.

“…Background: Multidrug resistance-associated protein (MRP) 1 and canalicular multispecific organic anion transporter (cMOAT or MRP2) are adenosine…”
Get full text

Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily by HOPPER, Elizabeth, BELINSKY, Martin G, HAO ZENG, TOSOLINI, Alessandra, TESTA, Joseph R, KRUH, Gary D

“…The MRP subfamily of ABC transporters currently consists of at least six members, several of which have been demonstrated to transport amphipathic anions and…”
Get full text

Expression complementary DNA library transfer establishes mrp as a multidrug resistance gene by KRUH, G. D, CHAN, A, MYERS, K, GAUGHAN, K, MIKI, T, AARONSON, S. A

“…The emergence of drug-resistant cancer cells is a major obstacle to cancer treatment. Resistant cells often display a multidrug-resistant phenotype that…”
Get full text

Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents by Zeng, H, Bain, L J, Belinsky, M G, Kruh, G D

“…Multidrug resistance-associated protein (MRP)1 and canalicular multispecific organic anion transporter (cMOAT)/MRP2 are ATP-binding cassette (ABC) transporters…”
Get full text

MRP subfamily transporters and resistance to anticancer agents by Kruh, G D, Zeng, H, Rea, P A, Liu, G, Chen, Z S, Lee, K, Belinsky, M G

“…The MRP subfamily of ABC transporters from mammals consists of at least seven members, six of which have been implicated in the transport of amphipathic…”
Get full text

Amplification of the ATP-binding cassette 2 transporter gene is functionally linked with enhanced efflux of estramustine in ovarian carcinoma cells by LAING, N. M, BELINSKY, M. G, KRUH, G. D, BELL, D. W, BOYD, J. T, BARONE, L, TESTA, J. R, TEW, K. D

“…An estramustine-resistant human ovarian carcinoma cell line, SKEM, was generated to explore resistance mechanisms associated with this agent. Cytogenetic…”
Get full text

ATP-Dependent Uptake of Natural Product Cytotoxic Drugs by Membrane Vesicles Establishes MRP as a Broad Specificity Transporter by Paul, Saptarshi, Breuninger, Lisa M., Tew, Kenneth D., Shen, Hongxie, Kruh, Gary D.

“…MRP is a recently isolated ATP-binding cassette family transporter. We previously reported transfection studies that established that MRP confers multidrug…”
Get full text

The Complete Coding Sequence of arg Defines the Abelson subfamily of Cytoplasmic Tyrosine Kinases by Kruh, Gary D., Perego, Roberto, Miki, Toru, Aaronson, Stuart A.

“…We have previously described partial genomic sequences of arg, a human gene related to c-abl, and shown that it is expressed as a 12-kilobase transcript and is…”
Get full text

The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance by O'Brien, M, Kruh, G D, Tew, K D

“…Glutathione (GSH), glutathione S-transferases (GSTs), and the multidrug resistance-associated protein 1 (MRP1) have been independently studied for their…”
Get more information