Search Results - "Kruglov, Andrei A."

Cell-type–restricted anti-cytokine therapy: TNF inhibition from one pathogenic source by Efimov, Grigory A., Kruglov, Andrei A., Khlopchatnikova, Zoya V., Rozov, Fedor N., Mokhonov, Vladislav V., Rose-John, Stefan, Scheller, Jürgen, Gordon, Siamon, Stacey, Martin, Drutskaya, Marina S., Tillib, Sergei V., Nedospasov, Sergei A.

“…Overexpression of TNF contributes to pathogenesis of multiple autoimmune diseases, accounting for a remarkable success of anti- TNF therapy. TNF is produced by…”
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Lymphotoxin Beta Receptor Signaling in Intestinal Epithelial Cells Orchestrates Innate Immune Responses against Mucosal Bacterial Infection by Wang, Yugang, Koroleva, Ekaterina P., Kruglov, Andrei A., Kuprash, Dmitry V., Nedospasov, Sergei A., Fu, Yang-Xin, Tumanov, Alexei V.

“…Epithelial cells provide the first line of defense against mucosal pathogens; however, their coordination with innate and adaptive immune cells is not well…”
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Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs by Tumanov, Alexei V., Grivennikov, Sergei I., Kruglov, Andrei A., Shebzukhov, Yuriy V., Koroleva, Ekaterina P., Piao, Yulan, Cui, Chang-Yi, Kuprash, Dmitry V., Nedospasov, Sergei A.

“…Secondary lymphoid organs provide a unique microenvironment for generation of immune responses. Using a cell type–specific conditional knockout approach, we…”
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ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock by Conrad, Udo, Plagmann, Ingo, Malchow, Sven, Sack, Markus, Floss, Doreen M, Kruglov, Andrei A, Nedospasov, Sergei A, Rose-John, Stefan, Scheller, Jürgen

“…Tumour necrosis factor (TNF) is a major pro-inflammatory cytokine involved in multiple inflammatory diseases. The detrimental activity of TNF can be blocked by…”
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Making anti-cytokine therapy more selective: Studies in mice by Drutskaya, Marina S., Efimov, Grigory A., Astrakhantseva, Irina V., Kruglov, Andrei A., Nedospasov, Sergei A.

“…[Display omitted] •Dysregulated cytokine signaling is often associated with the development of autoimmunity.•Systemic cytokine ablation is used to treat…”
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Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: Mouse models by Kruglov, Andrei A, Kuchmiy, Anna, Grivennikov, Sergei I, Tumanov, Alexei V, Kuprash, Dmitry V, Nedospasov, Sergei A

“…Abstract TNF is an exciting cytokine which has helped to establish many paradigms in immunology. Although TNF itself has found only very limited use in the…”
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Transglutaminase-catalyzed covalent multimerization of camelidae anti-human TNF single domain antibodies improves neutralizing activity by Plagmann, Ingo, Chalaris, Athena, Kruglov, Andrei A., Nedospasov, Sergei, Rosenstiel, Philip, Rose-John, Stefan, Scheller, Jürgen

“…Tumor necrosis factor (TNF) plays an important role in chronic inflammatory disorders, such as Rheumatoid Arthritis and Crohn's disease. Recently, monoclonal…”
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Inflammation-induced formation of fat-associated lymphoid clusters by Bénézech, Cécile, Luu, Nguyet-Thin, Walker, Jennifer A, Kruglov, Andrei A, Loo, Yunhua, Nakamura, Kyoko, Zhang, Yang, Nayar, Saba, Jones, Lucy H, Flores-Langarica, Adriana, McIntosh, Alistair, Marshall, Jennifer, Barone, Francesca, Besra, Gurdyal, Miles, Katherine, Allen, Judith E, Gray, Mohini, Kollias, George, Cunningham, Adam F, Withers, David R, Toellner, Kai Michael, Jones, Nick D, Veldhoen, Marc, Nedospasov, Sergei A, McKenzie, Andrew N J, Caamaño, Jorge H

“…Fat-associated lymphoid clusters are lymphoid tissues that support B-1 cells. Caamaño and colleagues show that inflammation that elicits the cytokine TNF and…”
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Novel tumor necrosis factor‐knockout mice that lack Peyer's patches by Kuprash, Dmitry V., Tumanov, Alexei V., Liepinsh, Dmitry J., Koroleva, Ekaterina P., Drutskaya, Marina S., Kruglov, Andrei A., Shakhov, Alexander N., Southon, Eileen, Murphy, William J., Tessarollo, Lino, Grivennikov, Sergei I., Nedospasov, Sergei A.

“…We generated a novel tumor necrosis factor (TNF) null mutation using Cre‐loxP technology. Mice homozygous for this mutation differ from their “conventional”…”
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Reverse Genetics Applied to Immunobiology of Tumor Necrosis Factor, a Multifunctional Cytokine by Nedospasov, Sergey A., Kruglov, Andrei A., Tumanov, Alexei V., Drutskaya, Marina S., Astrakhantseva, Irina V., Kuprash, Dmitry V.

“…Tumor necrosis factor (TNF) is one of many cytokines – protein molecules responsible for communication between the cells of immune system. TNF was discovered…”
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Can we design a better anti‐cytokine therapy? by Drutskaya, Marina S., Efimov, Grigory A., Kruglov, Andrei A., Nedospasov, Sergei A.

“…Systemic cytokine ablation has revolutionized the treatment of autoimmune diseases; however, development of more specific and cell type‐restricted cytokine…”
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Will Peptides Help to Stop COVID-19? by Krut’, Viktoriya G., Chuvpilo, Sergei A., Astrakhantseva, Irina V., Kozlovskaya, Liubov I., Efimov, Grigory A., Kruglov, Andrei A., Drutskaya, Marina S., Nedospasov, Sergei A.

“…Peptides are widely used for the diagnostics, prevention, and therapy of certain human diseases. How useful can they be for the disease caused by the…”
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Modulation of bioavailability of proinflammatory cytokines produced by myeloid cells by Nosenko, Maxim A., Atretkhany, Kamar-Sulu N., Mokhonov, Vladislav V., Vasilenko, Ekaterina A., Kruglov, Andrei A., Tillib, Sergei V., Drutskaya, Marina S., Nedospasov, Sergei A.

“…In spite of successful therapeutic neutralization of proinflammatory cytokines in several autoimmune diseases, such therapy is not entirely free of side…”
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Distinct and Nonredundant In Vivo Functions of TNF Produced by T Cells and Macrophages/Neutrophils: Protective and Deleterious Effects by Grivennikov, Sergei I., Tumanov, Alexei V., Liepinsh, Dmitry J., Kruglov, Andrei A., Marakusha, Boris I., Shakhov, Alexander N., Murakami, Takaya, Drutskaya, Ludmila N., Förster, Irmgard, Clausen, Björn E., Tessarollo, Lino, Ryffel, Bernhard, Kuprash, Dmitry V., Nedospasov, Sergei A.

“…Tumor necrosis factor (TNF, TNFα) is implicated in various pathophysiological processes and can be either protective, as in host defense, or deleterious, as in…”
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Comment on "experimental arthritis triggers periodontal disease in mice: involvement of TNF-α and the oral microbiota" by Kruglov, Andrei A, Nedospasov, Sergei A

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Experimental applications of TNF-reporter mice with far-red fluorescent label by Shebzukhov, Yury V, Kuchmiy, Anna A, Kruglov, Andrei A, Zipp, Frauke, Siffrin, Volker, Nedospasov, Sergei A

“…This chapter provides protocols for in vitro and in vivo analysis of TNF-producing cells from a novel TNF reporter mouse. In these transgenic mice, genetic…”
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Accelerated thymic atrophy as a result of elevated homeostatic expression of the genes encoded by the TNF/lymphotoxin cytokine locus by Liepinsh, Dmitry J., Kruglov, Andrei A., Galimov, Arthur R., Shakhov, Alexander N., Shebzukhov, Yuriy V., Kuchmiy, Anna A., Grivennikov, Sergei I., Tumanov, Alexei V., Drutskaya, Marina S., Feigenbaum, Lionel, Kuprash, Dmitry V., Nedospasov, Sergei A.

“…TNF, lymphotoxin (LT)‐α, LT‐β and LIGHT are members of a larger superfamily of TNF‐related cytokines that can cross‐utilize several receptors. Although LIGHT…”
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Lymphoid organ specificity in the maintenance of secondary lymphoid tissues by TNF produced by B and T cells (95.26) by Tumanov, Alexei, Grivennikov, Sergei I, Kruglov, Andrei A, Kuprash, Dmitry V, Nedospasov, Sergei A

“…Abstract Secondary lymphoid organs play an important role in generation of efficient immune responses. Using a genetic approach we revealed distinct…”
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Distinct and Nonredundant In Vivo Functions of TNF Produced by T Cells and Macrophages/Neutrophils by Grivennikov, Sergei I., Tumanov, Alexei V., Liepinsh, Dmitry J., Kruglov, Andrei A., Marakusha, Boris I., Shakhov, Alexander N., Murakami, Takaya, Drutskaya, Ludmila N., Förster, Irmgard, Clausen, Björn E., Tessarollo, Lino, Ryffel, Bernhard, Kuprash, Dmitry V., Nedospasov, Sergei A.

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