Search Results - "Kruger, A E"

Thalidomide neuropathy in patients treated for metastatic prostate cancer by Molloy, F.M., Floeter, M.K., Syed, N.A., Sandbrink, F., Culcea, E., Steinberg, S.M., Dahut, W., Pluda, J., Kruger, E.A., Reed, E., Figg, W.D.

“…We prospectively evaluated thalidomide‐induced neuropathy using electrodiagnostic studies. Sixty‐seven men with metastatic androgen‐independent prostate cancer…”
Get full text

TNP-470: an angiogenesis inhibitor in clinical development for cancer by Kruger, E A, Figg, W D

“…TNP-470, an analogue of fumagillin, has been shown to inhibit angiogenesis in vitro and in vivo. In 1992, TNP-470 entered clinical development for cancer as an…”
Get more information

The Angiogenesis Inhibitor, Endostatin, Does Not Affect Murine Cutaneous Wound Healing by Berger, Adam C., Feldman, Andrew L., Gnant, Michael F.X., Kruger, Erwin A., Sim, B.Kim Lee, Hewitt, Stephen, Figg, William D., Alexander, H.Richard, Libutti, Steven K.

“…Background. Endostatin is a potent angiogenesis inhibitor, which is currently being used in Phase I trials as an antitumor agent. The purpose of this study was…”
Get full text

POSSIBLE PROSPECTS DEVELOPMENT OF THE MODERN INFECTIOLOGY by I. V. Bogadelnikov, E. A. Kruger, A. V. Bobrysheva, N. I. Muzhetskaya

“…On the basis of current scientific evidence substantiated opinion about the primacy of the prokaryotes (bacteria and viruses) in the existence of human life…”
Get full text

A Randomized Phase II Trial of Thalidomide, an Angiogenesis Inhibitor, in Patients with Androgen-independent Prostate Cancer by FIGG, William D, DAHUT, William, CHEN, Clara C, DIXON, Shannon, KOHLER, David R, KRÜGER, Erwin A, GUBISH, Ed, PLUDA, James M, REED, Eddie, DURAY, Paul, HAMILTON, Michael, TOMPKINS, Anne, STEINBERG, Seth M, JONES, Elizabeth, PREMKUMAR, Ahalya, LINEHAN, W. Marston, FLOETER, Mary Kay

“…Purpose: Thalidomide is a potent teratogen that causes dysmelia in humans. Recently, in vitro data suggested that it inhibits angiogenesis. Prostate cancer is…”
Get full text

Complications of transrectal ultrasound-guided systematic sextant biopsies of the prostate: evaluation of complication rates and risk factors within a population-based screening program by Rietbergen, John B.W., Kruger, Arto E.Boeken, Kranse, Ries, Schröder, Fritz H.

“…Objectives. Screening for prostate cancer to reduce the mortality and morbidity from this disease has become an important issue in recent years. Of all…”
Get full text

Repeat screening for prostate cancer after 1-year followup in 984 biopsied men: clinical and pathological features of detected cancer by Rietbergen, J B, Kruger, A E, Hoedemaeker, R F, Bangma, C H, Kirkels, W J, Schröder, F H

“…We describe the yield of a repeat examination and biopsy procedure 1 year after initial biopsy was negative. We also assessed the parameters responsible for…”
Get more information

Evaluation of prostate needle biopsies in a population-based screening study : The impact of borderline lesions by HOEDEMAEKER, R. F, KRANSE, R, RIETBERGEN, J. B. W, KRUGER, A. E. B, SCHRÖDER, F. H, VAN DER KWAST, T. H

“…The finding of isolated high grade prostatic intraepithelial neoplasia (PIN) or borderline lesions (lesions suspicious for malignancy) in prostate needle…”
Get full text

Approaches to preclinical screening of antiangiogenic agents by Kruger, E A, Duray, P H, Price, D K, Pluda, J M, Figg, W D

“…Angiogenesis, or new blood vessel growth, is essential for the growth, invasion, and metastasis of solid tumors. The inhibition of this process, or…”
Get more information

Thalidomide up-regulates prostate-specific antigen secretion from LNCaP cells by DIXON, S. C, KRUGER, E. A, BAUER, K. S, FIGG, W. D

Get full text

Endostatin Inhibits Microvessel Formation in the ex Vivo Rat Aortic Ring Angiogenesis Assay by Kruger, Erwin A., Duray, Paul H., Tsokos, Maria G., Venzon, David J., Libutti, Steven K., Dixon, Shannon C., Rudek, Michelle A., Pluda, James, Allegra, Carmen, Figg, William D.

“…Endostatin has demonstrated potent antiangiogenic and antitumor activity in mouse models. We have investigated the ex vivo rat aortic ring assay and a human…”
Get full text

Antiangiogenic activity of N-substituted and tetrafluorinated thalidomide analogues by NG, Sylvia S. W, GÜTSCHOW, Michael, WEISS, Michael, HAUSCHILDT, Sunna, TEUBERT, Uwe, HECKER, Thomas K, LUZZIO, Frederick A, KRUGER, Erwin A, EGER, Kurt, FIGG, William D

“…Inhibition of angiogenesis is currently perceived as one of the promising strategies in the treatment of cancer. The antiangiogenic property of thalidomide has…”
Get full text

Carboxyamido-triazole inhibits angiogenesis by blocking the calcium-mediated nitric-oxide synthase-vascular endothelial growth factor pathway by Bauer, K S, Cude, K J, Dixon, S C, Kruger, E A, Figg, W D

“…The induction of angiogenesis is known to play a critical role in the successful growth, invasion, and metastasis of a tumor. A tumor will not grow beyond a…”
Get more information

Comparison of prostate-specific antigen corrected for total prostate volume and transition zone volume in a population-based screening study by Rietbergen, John B.W, Kranse, Ries, Hoedemaeker, Robert F, Kruger, Arto E.Boeken, Bangma, Chris H, Kirkels, Wim J, Schröder, Fritz H

“…Objectives. To compare the discriminatory potential between prostate cancer and benign conditions of the prostate in a population-based screening study, of…”
Get full text

Protein Binding Alters the Activity of Suramin, Carboxyamidotriazole, and UCN-01 in an ex Vivo Rat Aortic Ring Angiogenesis Assay by KRÜGER, Erwin A, FIGG, William D

“…Angiogenesis inhibitors are currently in clinical development for cancer. These agents pose unique developmental challenges: ( a ) determining maximum…”
Get full text

Getting to Know Ourselves and Our Places Through Participation in Civic Social Assessment by Kruger, Linda E, Shannon, Margaret A

“…Civic science (involving citizens as researchers) expands opportunities for learning among citizens, scientists, and managers. Citizens have knowledge that…”
Get full text

Thalidomide up-regulates prostate-specific antigen secretion from LNCaP cells by Dixon, S C, Kruger, E A, Bauer, K S, Figg, W D

“…Thalidomide has been shown to have species- and metabolic-dependent antiangiogenic activity in vitro and in vivo, suggesting its potential in treating human…”
Get full text

On the standardization of total prostate-specific antigen: an exercise with two reference preparations by Blijenberg, B G, Storm, B N, Kruger, A E, Schröder, F H

“…In this study, 112 serum samples were analyzed for total prostate-specific antigen with three well-established assays i.e. Tandem R and Tandem E (both from…”
Get more information

Microarray gene expression profiling of angiogenesis inhibitors using the rat aortic ring assay by Zogakis, T G, Costouros, N G, Kruger, E A, Forbes, S, He, M, Qian, M, Feldman, A L, Figg, W D, Alexander, H R, Liu, E T, Kohn, E C, Libutti, S K

“…The rat aortic ring assay has been previously described as a useful ex vivo model for analyzing the biological activity of various inhibitors of angiogenesis…”
Get full text

The changing pattern of prostate cancer at the time of diagnosis: characteristics of screen detected prostate cancer in a population based screening study by Rietbergen, J B, Hoedemaeker, R F, Kruger, A E, Kirkels, W J, Schröder, F H

“…We describe the clinical and pathological features of prostate cancer diagnosed through serum prostate specific antigen (PSA), digital rectal examination and…”
Get more information