Search Results - "Krueger, Sharon K."

Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism by Krueger, Sharon K, Williams, David E

“…Flavin-containing monooxygenase (FMO) oxygenates drugs and xenobiotics containing a "soft-nucleophile", usually nitrogen or sulfur. FMO, like cytochrome P450…”
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Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse by Siddens, Lisbeth K., Larkin, Andrew, Krueger, Sharon K., Bradfield, Christopher A., Waters, Katrina M., Tilton, Susan C., Pereira, Cliff B., Löhr, Christiane V., Arlt, Volker M., Phillips, David H., Williams, David E., Baird, William M.

“…The polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), was compared to dibenzo[def,p]chrysene (DBC) and combinations of three environmental PAH…”
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Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse by Siddens, Lisbeth K., Bunde, Kristi L., Harper, Tod A., McQuistan, Tammie J., Löhr, Christiane V., Bramer, Lisa M., Waters, Katrina M., Tilton, Susan C., Krueger, Sharon K., Williams, David E., Baird, William M.

“…FVB/N mice wild-type, heterozygous or null for Cyp 1b1 were used in a two-stage skin tumor study comparing PAH, benzo[a]pyrene (BaP), dibenzo[def,p]chrysene…”
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Flavin-containing monooxygenase-3: Induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver by Celius, Trine, Pansoy, Andrea, Matthews, Jason, Okey, Allan B., Henderson, Marilyn C., Krueger, Sharon K., Williams, David E.

“…Flavin-containing monooxygenases often are thought not to be inducible but we recently demonstrated aryl hydrocarbon receptor (AHR)-dependent induction of FMO…”
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Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygenases and peroxidases by Vyas, Piyush M, Roychowdhury, Sanjoy, Koukouritaki, Sevasti B, Hines, Ronald N, Krueger, Sharon K, Williams, David E, Nauseef, William M, Svensson, Craig K

“…Arylamine compounds, such as sulfamethoxazole (SMX) and dapsone (DDS), are metabolized in epidermal keratinocytes to arylhydroxylamine metabolites that…”
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Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants by Koukouritaki, Sevasti B, Poch, Mark T, Henderson, Marilyn C, Siddens, Lisbeth K, Krueger, Sharon K, VanDyke, Jonathan E, Williams, David E, Pajewski, Nicholas M, Wang, Tao, Hines, Ronald N

“…Flavin-containing monooxygenases (FMOs) are important for the disposition of many therapeutics, environmental toxicants, and nutrients. FMO3, the major adult…”
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Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms by Siddens, Lisbeth K., Henderson, Marilyn C., VanDyke, Jonathan E., Williams, David E., Krueger, Sharon K.

“…The significance of active versus inactive flavin-containing monooxygenase 2 (FMO2) for human drug and xenobiotic metabolism and sensitivity is unknown, but…”
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Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide by Siddens, Lisbeth K., Krueger, Sharon K., Henderson, Marilyn C., Williams, David E.

“…Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2…”
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Metabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse by Palmer, Amy L, Leykam, Virginia L, Larkin, Andrew, Krueger, Sharon K, Phillips, Ian R, Shephard, Elizabeth A, Williams, David E

“…Multiple drug resistance (MDR) in Mycobacterium tuberculosis (mTB), the causative agent for tuberculosis (TB), has led to increased use of second-line drugs,…”
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Characterization of Sulfoxygenation and Structural Implications of Human Flavin-Containing Monooxygenase Isoform 2 (FMO2.1) Variants S195L and N413K by Krueger, Sharon K, Henderson, Marilyn C, Siddens, Lisbeth K, VanDyke, Jonathan E, Benninghoff, Abby D, Karplus, P Andrew, Furnes, Bjarte, Schlenk, Daniel, Williams, David E

“…Catalytically active human flavin-containing monooxygenase isoform 2 (FMO2.1) is encoded by an allele detected only in individuals of African or Hispanic…”
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Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction by Hummel, Jessica M., Madeen, Erin P., Siddens, Lisbeth K., Uesugi, Sandra L., McQuistan, Tammie, Anderson, Kim A., Turteltaub, Kenneth W., Ognibene, Ted J., Bench, Graham, Krueger, Sharon K., Harris, Stuart, Smith, Jordan, Tilton, Susan C., Baird, William M., Williams, David E.

“…Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is a known human carcinogen. In non-smoking adults greater than 95% of BaP exposure is through…”
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Identification of Active Flavin-Containing Monooxygenase Isoform 2 in Human Lung and Characterization of Expressed Protein by KRUEGER, Sharon K, MARTIN, Sarah R, YUEH, Mei-Fei, PEREIRA, Clifford B, WILLIAMS, David E

“…Full-length human (hFMO2.1) and monkey (mFMO2) flavin-containing monooxygenase proteins, which share 97% sequence identity, were produced by…”
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DIFFERENCES IN FMO21 ALLELIC FREQUENCY BETWEEN HISPANICS OF PUERTO RICAN AND MEXICAN DESCENT by Krueger, Sharon K, Siddens, Lisbeth K, Martin, Sarah R, Yu, Zhen, Pereira, Clifford B, Cabacungan, Erwin T, Hines, Ronald N, Ardlie, Kristin G, Raucy, Judy L, Williams, David E

“…A polymorphism for the phase I drug-metabolizing enzyme, flavin-containing monooxygenase isoform 2 (FMO2), encoding either truncated inactive protein, FMO2X472…”
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Mechanism-Based Classification of PAH Mixtures to Predict Carcinogenic Potential by Tilton, Susan C, Siddens, Lisbeth K, Krueger, Sharon K, Larkin, Andrew J, Löhr, Christiane V, Williams, David E, Baird, William M, Waters, Katrina M

“…We have previously shown that relative potency factors and DNA adduct measurements are inadequate for predicting carcinogenicity of certain polycyclic aromatic…”
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C-terminal truncation of rabbit flavin-containing monooxygenase isoform 2 enhances solubility by Krueger, Sharon K., Siddens, Lisbeth K., Henderson, Marilyn C., VanDyke, Jonathan E., Karplus, P. Andrew, Pereira, Clifford B., Williams, David E.

“…Flavin-containing monooxygenases (FMO) are membrane-associated enzymes contributing to oxidative metabolism of drugs and other chemicals. There are no known…”
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Dibenzo[def,p]chrysene transplacental carcinogenesis in wild‐type, Cyp1b1 knockout, and CYP1B1 humanized mice by Madeen, Erin P., Löhr, Christiane V., You, Hannah, Siddens, Lisbeth K., Krueger, Sharon K., Dashwood, Roderick H., Gonzalez, Frank J., Baird, William M., Ho, Emily, Bramer, Lisa, Waters, Katrina M., Williams, David E.

“…The cytochrome P450 (CYP) 1 family is active toward numerous environmental pollutants, including polycyclic aromatic hydrocarbons (PAHs). Utilizing a mouse…”
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Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones by Henderson, Marilyn C., Siddens, Lisbeth K., Krueger, Sharon K., Stevens, J. Fred, Kedzie, Karen, Fang, Wenkui K., Heidelbaugh, Todd, Nguyen, Phong, Chow, Ken, Garst, Michael, Gil, Daniel, Williams, David E.

“…Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and…”
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Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes by Henderson, Marilyn C., Siddens, Lisbeth K., Morré, Jeffrey T., Krueger, Sharon K., Williams, David E.

“…Tuberculosis (TB) results from infection with Mycobacterium tuberculosis and remains endemic throughout the world with one-third of the world's population…”
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α-Tocopherol modulates Cyp3a expression, increases γ-CEHC production, and limits tissue γ-tocopherol accumulation in mice fed high γ-tocopherol diets by Traber, Maret G., Siddens, Lisbeth K., Leonard, Scott W., Schock, Bettina, Gohil, Kishorchandra, Krueger, Sharon K., Cross, Carroll E., Williams, David E.

“…Although all forms of vitamin E are absorbed, the liver preferentially secretes α-, but not γ-tocopherol, into plasma. Liver α-tocopherol secretion is under…”
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Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin by Larkin, Andrew, Siddens, Lisbeth K., Krueger, Sharon K., Tilton, Susan C., Waters, Katrina M., Williams, David E., Baird, William M.

“…Polycyclic aromatic hydrocarbons (PAHs) are present in the environment as complex mixtures with components that have diverse carcinogenic potencies and mostly…”
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