Search Results - "Krueger, JA"

Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: results of an international collaborative trial by TOLLEFSON, G. D, BEASLEY, C. M, TRAN, P. V, STREET, J. S, KRUEGER, J. A, TAMURA, R. N, GRAFFEO, K. A, THIEME, M. E

“…OBJECTIVE: This international, multicenter double-blind trial was designed to compare the therapeutic profile of an atypical antipsychotic, olanzapine, with…”
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Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes by Chen, Lichao, Majde, Jeannine A., Krueger, James M.

“…Nitric oxide (NO) affects almost every physiological process, including the regulation of sleep. There is strong evidence that NO plays an important role in…”
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Discovery and Evaluation of Potent P 1 Aryl Heterocycle-Based Thrombin Inhibitors by Young, Mary Beth, Barrow, James C., Glass, Kristen L., Lundell, George F., Newton, Christina L., Pellicore, Janetta M., Rittle, Kenneth E., Selnick, Harold G., Stauffer, Kenneth J., Vacca, Joseph P., Williams, Peter D., Bohn, Dennis, Clayton, Franklin C., Cook, Jacquelynn J., Krueger, Julie A., Kuo, Lawrence C., Lewis, S. Dale, Lucas, Bobby J., McMasters, Daniel R., Miller-Stein, Cynthia, Pietrak, Beth L., Wallace, Audrey A., White, Rebecca B., Wong, Bradley, Yan, Youwei, Nantermet, Philippe G.

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Cyclopropylamino Acid Amide as a Pharmacophoric Replacement for 2,3-Diaminopyridine. Application to the Design of Novel Bradykinin B 1 Receptor Antagonists by Wood, Michael R., Schirripa, Kathy M., Kim, June J., Wan, Bang-Lin, Murphy, Kathy L., Ransom, Richard W., Chang, Raymond S. L., Tang, Cuyue, Prueksaritanont, Thomayant, Detwiler, Theodore J., Hettrick, Lisa A., Landis, Elizabeth R., Leonard, Yvonne M., Krueger, Julie A., Lewis, Sidney D., Pettibone, Douglas J., Freidinger, Roger M., Bock, Mark G.

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Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization by Deng, James Z., McMasters, Daniel R., Rabbat, Philippe M.A., Williams, Peter D., Coburn, Craig A., Yan, Youwei, Kuo, Lawrence C., Lewis, S. Dale, Lucas, Bobby J., Krueger, Julie A., Strulovici, Berta, Vacca, Joseph P., Lyle, Terry A., Burgey, Christopher S.

“…Thrombin-inhibitor X-ray crystal structures, in combination with the installation of binding elements optimized within the pyrazinone series of thrombin…”
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9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors by Stauffer, Kenneth J, Williams, Peter D, Selnick, Harold G, Nantermet, Philippe G, Newton, Christina L, Homnick, Carl F, Zrada, Matthew M, Lewis, S. Dale, Lucas, Bobby J, Krueger, Julie A, Pietrak, Beth L, Lyle, Elizabeth A, Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B, Wong, Bradley, Wallace, Audrey A, Sitko, Gary R, Cook, Jacquelyn J, Holahan, Marie A, Stranieri-Michener, Maria, Leonard, Yvonne M, Lynch, Joseph J, McMasters, Daniel R, Yan, Youwei

“…Optimization of a previously reported thrombin inhibitor, 9-hydroxy-9-fluorenylcarbonyl-l-prolyl-trans-4-aminocyclohexylmethylamide (1), by replacing the…”
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The extent and distribution of cell death and matrix damage in impacted chondral explants varies with the presence of underlying bone by Krueger, J A, Thisse, P, Ewers, B J, Dvoracek-Driksna, D, Orth, M W, Haut, R C

“…Excessive mechanical loading can lead to matrix damage and chondrocyte death in articular cartilage. Previous studies on chondral and osteochondral explants…”
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Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles by Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J.

“…Imidazoles and aminothiazoles, in spite of their weak basicity, have been optimized to function as potent P1 ligands in both a peptide series and a nonpeptide…”
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Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the ‘Distal binding pocket’ by Sanderson, Philip E.J., Cutrona, Kellie J., Dyer, Dona L., Krueger, Julie A., Kuo, Lawrence C., Lewis, S.Dale, Lucas, Bobby J., Yan, Youwei

“…Use of a chlorophenoxyacetamide P1 group with a pyridinone acetamide P2/P3 gave an exceptionally potent thrombin inhibitor ( K i=40 pM). Truncation of the…”
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P 2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold by Nantermet, Philippe G., Burgey, Christopher S., Robinson, Kyle A., Pellicore, Janetta M., Newton, Christina L., Deng, James Z., Selnick, Harold G., Lewis, S. Dale, Lucas, Bobby J., Krueger, Julie A., Miller-Stein, Cynthia, White, Rebecca B., Wong, Bradley, McMasters, Daniel R., Wallace, Audrey A., Lynch, Joseph J., Yan, Youwei, Chen, Zhongguo, Kuo, Lawrence, Gardell, Stephen J., Shafer, Jules A., Vacca, Joseph P., Lyle, Terry A.

“…In this study, we demonstrate that the critical hydrogen bonding motif of the established 3-aminopyrazinone thrombin inhibitors can be effectively mimicked by…”
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Cyclopropylamino Acid Amide as a Pharmacophoric Replacement for 2,3-Diaminopyridine. Application to the Design of Novel Bradykinin B sub(1) Receptor Antagonists by Wood, M R, Schirripa, K M, Kim, J J, Wan, B-L, Murphy, K L, Ransom, R W, Chang, RSL, Tang, C, Prueksaritanont, L T, Detwiler, T J, Hettrick, LA, Landis, E R, Leonard, Y M, Krueger, JA

“…Antagonism of the bradykinin B sub(1) receptor represents a potential treatment for chronic pain and inflammation. Novel antagonists were designed that display…”
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Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position by RITTLE, Kenneth E, BARROW, James C, NANTERMET, Philippe G, NEWTON, Christina L, SANDERS, William M, YOUWEI YAN, VACCA, Joseph P, SELNICK, Harold G, CUTRONA, Kellie J, GLASS, Kristen L, KRUEGER, Julie A, KUO, Lawrence C, LEWIS, S. Dale, LUCAS, Bobby J, MCMASTERS, Daniel R, MORRISSETTE, Matthew M

“…Thrombin inhibitors incorporating o-aminoalkylbenzylamides in the P1 position were designed, synthesized and found to have enhanced potency and selectivity in…”
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Azaindoles: moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors by Sanderson, Philip E.J., Stanton, Matthew G., Dorsey, Bruce D., Lyle, Terry A., McDonough, Colleen, Sanders, William M., Savage, Kelly L., Naylor-Olsen, Adel M., Krueger, Julie A., Lewis, S.Dale, Lucas, Bobby J., Lynch, Joseph J., Yan, Youwei

“…Starting from a 2-amino-6-methylpyridine P1 group and following a strategy of enlarging it whilst reducing its polarity, we have developed a series of potent,…”
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Design and synthesis of potent and selective macrocyclic thrombin inhibitors by Nantermet, Philippe G., Barrow, James C., Newton, Christina L., Pellicore, Janetta M., Young, MaryBeth, Lewis, S.Dale, Lucas, Bobby J., Krueger, Julie A., McMasters, Daniel R., Yan, Youwei, Kuo, Lawrence C., Vacca, Joseph P., Selnick, Harold G.

“…A series of potent and selective proline- and pyrazinone-based macrocyclic thrombin inhibitors is described. Detailed SAR studies led to the incorporation of…”
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Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability by Morrissette, Matthew M, Stauffer, Kenneth J, Williams, Peter D, Lyle, Terry A, Vacca, Joseph P, Krueger, Julie A, Lewis, S.Dale, Lucas, Bobby J, Wong, Bradley K, White, Rebecca B, Miller-Stein, Cynthia, Lyle, Elizabeth A, Wallace, Audrey A, Leonard, Yvonne M, Welsh, Denise C, Lynch, Joseph J, McMasters, Daniel R

“…In order to overcome several limitations of our lead compound, which possessed a fluorenyl side chain in P3, we synthesized a series of analogs where we…”
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Growth and injury patterns of eastern white pine (Pinus strobus L.) seedlings as affected by hardwood overstory density and weeding treatments by Krueger, J.A, Puettmann, K.J

“…White pine seedlings were underplanted under a range of overstory densities in a hardwood stand in northern Minnesota. Vegetation surrounding seedlings was…”
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L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor by Sanderson, Philip E.J., Cutrona, Kellie J., Dorsey, Bruce D., Dyer, Dona L., McDonough, Colleen M., Naylor-Olsen, Adel M., Chen, I-Wu, Chen, Zhongguo, Cook, Jacquelynn J., Gardell, Stephen J., Krueger, Julie A., Lewis, S.Dale, Lin, Jiunn H., Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Stranieri, Maria T., Vastag, Kari, Shafer, Jules A., Vacca, Joseph P.

“…Replacement of the amidinopiperidine P1 group of 3-benzylsulfonylamino-6-methyl-2-pyridinone acetamide thrombin inhibitor L-373,890 ( 2) with a mildly basic…”
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3-Amino-4-sulfonylpyridinone acetamide and related pyridothiadiazine thrombin inhibitors by Sanderson, Philip E.J., Cutrona, Kellie J., Savage, Kelly L., Naylor-Olsen, Adel M., Bickel, Denise J., Bohn, Dennis L., Clayton, Franklin C., Krueger, Julie A., Lewis, S.Dale, Lucas, Bobby J., Lyle, Elizabeth A., Wallace, Audrey A., Welsh, Denice C., Yan, Youwei

“…We describe a series of highly potent and efficacious thrombin inhibitors based on a 3-amino-4-sulfonylpyridinone acetamide template. The functionally dense…”
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Early growth responses of naturally regenerated eastern white pine (Pinus strobus L.) to partial release from juvenile aspen and pathological pruning by Zenner, E.K, Puettmann, K.J, Krueger, J.A

“…Height, breast height diameter, and basal diameter growth responses of 7- to 12-year-old naturally regenerated eastern white pine (Pinus strobus L.) to partial…”
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Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors by Coburn, C A, Rush, D M, Williams, P D, Homnick, C, Lyle, E A, Lewis, S D, Lucas, Jr, B J, Di Muzio-Mower, J M, Juliano, M, Krueger, J A, Vastag, K, Chen, I W, Vacca, J P

“…A new class of conformationally constrained thrombin inhibitors is described. These compounds contain a unique bicyclic pyridone scaffold which serves as a…”
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