Search Results - "Krueger, Darcy"

Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex by MacKeigan, Jeffrey P, Krueger, Darcy A

“…Tuberous sclerosis complex (TSC) is a genetic autosomal dominant disorder characterized by benign tumor-like lesions, called hamartomas, in multiple organ…”
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Everolimus treatment of refractory epilepsy in tuberous sclerosis complex by Krueger, Darcy A., Wilfong, Angus A., Holland-Bouley, Katherine, Anderson, Anne E., Agricola, Karen, Tudor, Cindy, Mays, Maxwell, Lopez, Christina M., Kim, Mi-Ok, Franz, David Neal

“…Objective Epilepsy is a major manifestation of tuberous sclerosis complex (TSC). Everolimus is an mammalian target of rapamycin complex 1 inhibitor with…”
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Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis by Krueger, Darcy A, Care, Marguerite M, Holland, Katherine, Agricola, Karen, Tudor, Cynthia, Mangeshkar, Prajakta, Wilson, Kimberly A, Byars, Anna, Sahmoud, Tarek, Franz, David Neal

“…Neurosurgical resection is standard for subependymal giant-cell astrocytomas (SEGAs) in tuberous sclerosis. Treatment with everolimus, which inhibits the…”
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Everolimus for subependymal giant cell astrocytoma: 5-year final analysis by Franz, David N., Agricola, Karen, Mays, Maxwell, Tudor, Cindy, Care, Marguerite M., Holland-Bouley, Katherine, Berkowitz, Noah, Miao, Sara, Peyrard, Séverine, Krueger, Darcy A.

“…Objective To analyze the cumulative efficacy and safety of everolimus in treating subependymal giant cell astrocytomas (SEGA) associated with tuberous…”
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Commentary Regarding the Results of the PREVeNT and EPISTOP Trials by Jóźwiak, Sergiusz, Kotulska, Katarzyna, Bebin, E. Martina, Krueger, Darcy A.

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The genomic landscape of tuberous sclerosis complex by Martin, Katie R., Zhou, Wanding, Bowman, Megan J., Shih, Juliann, Au, Kit Sing, Dittenhafer-Reed, Kristin E., Sisson, Kellie A., Koeman, Julie, Weisenberger, Daniel J., Cottingham, Sandra L., DeRoos, Steven T., Devinsky, Orrin, Winn, Mary E., Cherniack, Andrew D., Shen, Hui, Northrup, Hope, Krueger, Darcy A., MacKeigan, Jeffrey P.

“…Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem growth of benign tumours and other hamartomatous lesions, which leads to diverse…”
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Long-term treatment of epilepsy with everolimus in tuberous sclerosis by Krueger, Darcy A, Wilfong, Angus A, Mays, Maxwell, Talley, Christina M, Agricola, Karen, Tudor, Cindy, Capal, Jamie, Holland-Bouley, Katherine, Franz, David Neal

“…OBJECTIVE:To evaluate the long-term benefit and safety of everolimus for the treatment of medically refractory epilepsy in patients with tuberous sclerosis…”
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Mammalian Target of Rapamycin Inhibitor Levels Decrease Under Cenobamate Treatment by Becker, Lena-Luise, Agricola, Karen, Ritter, David M., Krueger, Darcy A., Franz, David Neal

“…Everolimus therapy has been approved in Tuberous Sclerosis Complex (TSC), for drug-resistant epilepsy as adjunctive therapy. A novel anti-seizure medication is…”
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Diagnostic methods and treatment options for focal cortical dysplasia by Guerrini, Renzo, Duchowny, Michael, Jayakar, Prasanna, Krsek, Pavel, Kahane, Philippe, Tassi, Laura, Melani, Federico, Polster, Tilman, Andre, Véronique M., Cepeda, Carlos, Krueger, Darcy A., Cross, J. Helen, Spreafico, Roberto, Cosottini, Mirco, Gotman, Jean, Chassoux, Francine, Ryvlin, Philippe, Bartolomei, Fabrice, Bernasconi, Andrea, Stefan, Hermann, Miller, Ian, Devaux, Bertrand, Najm, Imad, Giordano, Flavio, Vonck, Kristl, Barba, Carmen, Blumcke, Ingmar

“…Summary Our inability to adequately treat many patients with refractory epilepsy caused by focal cortical dysplasia (FCD), surgical inaccessibility and…”
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Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma by KRUEGER, Darcy A, CARE, Marguerite M, AGRICOLA, Karen, TUDOR, Cindy, MAYS, Maxwell, FRANZ, David Neal

“…To report long-term efficacy and safety data for everolimus for the treatment of subependymal giant cell astrocytoma (SEGA) in patients with tuberous sclerosis…”
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Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing by Tyburczy, Magdalena E, Dies, Kira A, Glass, Jennifer, Camposano, Susana, Chekaluk, Yvonne, Thorner, Aaron R, Lin, Ling, Krueger, Darcy, Franz, David N, Thiele, Elizabeth A, Sahin, Mustafa, Kwiatkowski, David J

“…Tuberous sclerosis complex (TSC) is an autosomal dominant tumor suppressor gene syndrome due to germline mutations in either TSC1 or TSC2. 10-15% of TSC…”
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Lymphangioleiomyomatosis Screening in Women With Tuberous Sclerosis by Cudzilo, Corey J., MD, Szczesniak, Rhonda D., PhD, Brody, Alan S., MD, Rattan, Mantosh S., MD, Krueger, Darcy A., MD, PhD, Bissler, John J., MD, Franz, David N., MD, McCormack, Francis X., MD, FCCP, Young, Lisa R., MD

“…Background Lymphangioleiomyomatosis (LAM) occurs in at least 40% of women with tuberous sclerosis complex (TSC), as diagnosed based on chest CT scan findings…”
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Central nervous system manifestations of tuberous sclerosis complex by Lu, Derek S., Karas, Patrick J., Krueger, Darcy A., Weiner, Howard L.

“…Tuberous sclerosis complex (TSC) is a neurocutaneous autosomal‐dominant genetic syndrome marked by development of hamartomatous lesions arising from…”
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Clinical Electroencephalographic Biomarker for Impending Epilepsy in Asymptomatic Tuberous Sclerosis Complex Infants by Wu, Joyce Y., MD, Peters, Jurriaan M., MD, PhD, Goyal, Monisha, MD, Krueger, Darcy, MD, PhD, Sahin, Mustafa, MD, PhD, Northrup, Hope, MD, Au, Kit Sing, MD, Cutter, Gary, PhD, Bebin, E. Martina, MD, MPA

“…Abstract Background We assessed the clinical utility of routine electroencephalography (EEG) in the prediction of epilepsy onset in asymptomatic infants with…”
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Cardiovascular Manifestations of Tuberous Sclerosis Complex and Summary of the Revised Diagnostic Criteria and Surveillance and Management Recommendations From the International Tuberous Sclerosis Consensus Group by Hinton, Robert B., Prakash, Ashwin, Romp, Robb L., Krueger, Darcy A., Knilans, Timothy K.

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Influence of seizures on early development in tuberous sclerosis complex by Capal, Jamie K, Bernardino-Cuesta, Beatriz, Horn, Paul S, Murray, Donna, Byars, Anna Weber, Bing, Nicole M, Kent, Bridget, Pearson, Deborah A, Sahin, Mustafa, Krueger, Darcy A

“…Abstract Objective Epilepsy is commonly seen in Tuberous Sclerosis Complex (TSC). The relationship between seizures and developmental outcomes has been…”
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Visual and semi-automatic non-invasive detection of interictal fast ripples: A potential biomarker of epilepsy in children with tuberous sclerosis complex by Bernardo, Danilo, Nariai, Hiroki, Hussain, Shaun A., Sankar, Raman, Salamon, Noriko, Krueger, Darcy A., Sahin, Mustafa, Northrup, Hope, Bebin, E. Martina, Wu, Joyce Y.

“…•This study provides evidence of the feasibility of recording fast ripples from scalp EEG.•Scalp fast ripples may represent a biomarker of epilepsy in children…”
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Impact of seizure onset zone and intracranial electroencephalography ictal characteristics on epilepsy surgery outcomes in tuberous sclerosis complex by Miecznikowski, Kara B., Leach, James, Rozhkov, Leonid, Mangano, Francesco T., Skoch, Jesse, Krueger, Darcy A., Horn, Paul S., Greiner, Hansel M.

“…Ninety percent of tuberous sclerosis complex (TSC) patients have seizures, with ∼50 % developing drug refractory epilepsy. Surgical intervention aims to remove…”
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Everolimus compliance and persistence among tuberous sclerosis complex patients with renal angiomyolipoma or subependymal giant cell astrocytoma by Song, Xue, Said, Qayyim, Tran, Oth, Krueger, Darcy A., Bissler, John

“…Objective: Everolimus is the only FDA approved drug to treat renal angiomyolipoma or subependymal giant-cell astrocytoma (SEGA) in tuberous sclerosis complex…”
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Early Treatment with Vigabatrin Does Not Decrease Focal Seizures or Improve Cognition in Tuberous Sclerosis Complex: The PREVeNT Trial by Bebin, Elizabeth Martina, Peters, Jurriaan M., Porter, Brenda E., McPherson, Tarrant O., O'Kelley, Sarah, Sahin, Mustafa, Taub, Katherine S., Rajaraman, Rajsekar, Randle, Stephanie C., McClintock, William M., Koenig, Mary Kay, Frost, Mike D., Northrup, Hope A., Werner, Klaus, Nolan, Danielle A., Wong, Michael, Krefting, Jessica L., Biasini, Fred, Peri, Kalyani, Cutter, Gary, Krueger, Darcy A.

“…Objective This study was undertaken to test the hypothesis that early vigabatrin treatment in tuberous sclerosis complex (TSC) infants improves neurocognitive…”
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