Search Results - "Kruczynski, A."

F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity by Kruczynski, A, Pillon, A, Créancier, L, Vandenberghe, I, Gomes, B, Brel, V, Fournier, E, Annereau, J-P, Currie, E, Guminski, Y, Bonnet, D, Bailly, C, Guilbaud, N

“…Chemotherapy remains mainly used for the treatment of acute myeloid leukemia (AML). However, in the past 3 decades limited progress has been achieved in…”
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423 EB1 Overexpression Promotes Glioblastoma Progression and Sensitizes to Microtubule-targeting Agents in Vitro and in Vivo by Berges, R, Blandin, A.F, Kruczynski, A, Braguer, D, Honore, S

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Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome by Vispé, S., Vandenberghe, I., Robin, M., Annereau, J.P., Créancier, L., Pique, V., Galy, J.P., Kruczynski, A., Barret, J.M., Bailly, C.

“…Acridine derivatives, such as amsacrine, represent a well known class of multi-targeted anti-cancer agents that generally interfere with DNA synthesis and…”
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57 New Models of Resistant Melanoma for Preclinical Assays by Robichon, C, Annereau, J.P, Gomes, B, Pillon, A, De Vries, L, Cussac, D, Meyer, N, Lamant, L, Kruczynski, A, Guilbaud, N

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285 Antiproliferative Activity of F, a Novel Polyamine-vectorized Drug, on Resistant Cancer Cells by Brel, V, Créancier, L, Marionneau-Brossard, M.L, Offrete, V, Verdier, J, Andre, K, Fournier, E, Kruczynski, A, Guilbaud, N, Annereau, J.P

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925 F14512, a Polyamine Vectorized Anti-cancer Drug Exhibits a Marked Antileukemic Activity, Alone and in Combination With AraC by Kruczynski, A, Pillon, A, Créancier, L, Vandenberghe, I, Gomes, B, Brel, V, Cartron, V, Chansard, N, Verdier, J, Guilbaud, N, Annereau, J.-P

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Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts by Hill, B.T, Fiebig, H.-H, Waud, W.R, Poupon, M.-F, Colpaert, F, Kruczynski, A

“…The antitumour activity of vinflunine, 20′,20′-dichloro-3′,4′-dihydrovinorelbine, a fluorinated Vinca alkaloid obtained by reaction in superacid media, was…”
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Characterization of cell death induced by vinflunine, the most recent Vinca alkaloid in clinical development by KRUCZYNSKI, A, ETIEVANT, C, PERRIN, D, CHANSARD, N, DUFLOS, A, HILL, B. T

“…Vinflunine, the most recent Vinca alkaloid in clinical development, demonstrated superior antitumour activity to other Vincas in preclinical tumour models…”
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Markedly diminished drug resistance-inducing properties of vinflunine (20', 20'-difluoro-3', 4'-dihydrovinorelbine) relative to vinorelbine, identified in murine and human tumour cells in vivo and in vitro by ETIEVANT, Chantal, KRUCZYNSKI, Anna, BARRET, Jean-Marc, TAIT, Alexandra S, KAVALLARIS, Maria, HILL, Bridget T

“…Vinflunine (VFL) is a novel Vinca alkaloid with markedly superior experimental in vivo antitumour activity to its parent molecule, vinorelbine (Navelbine,…”
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Preclinical antitumour activity of F 11782, a novel dual catalytic inhibitor of topoisomerases by KRUCZYNSKI, A, ETIEVANT, C, PERRIN, D, IMBERT, T, COLPAERT, F, HILL, B. T

“…F 11782 is a novel inhibitor of topoisomerases I and II, with an original mechanism of action (Perrin et al, 2000). This study, aimed to define its anticancer…”
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In vivo antitumor activity of F 11782, a non-intercalating dual catalytic inhibitor of topoisomerases I and II, against a panel of human tumor xenografts by Kruczynski, A, Ricome, C, Waud, W R, Hill, B T

“…The marked in vivo antitumor activity of F 11782 against murine experimental tumors (Kruczynski et al., Br J Cancer 83: 1516-24, 2000) has now been confirmed…”
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Detection of DNA-strand breaks in cells treated with F 11782, a catalytic inhibitor of topoisomerases I and II by Barret, J M, Montaudon, D, Etiévant, C, Perrin, D, Kruczynski, A, Robert, J, Hill, B T

“…F 11782, or 2", 3"-bis pentafluorophenoxyacetyl-4',6'-ethylidene-beta-D glucoside of 4'-phosphate-4'-dimethylepipodophyllotoxin 2N-methyl glucamine salt, is a…”
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Characterisation of the influence of anti-gastrin, anti-epidermal growth factor, anti-oestradiol, and anti-luteinising hormone releasing hormone antibodies on the proliferation of 27 cell lines from the gastrointestinal tract by Darro, F, Camby, I, Kruczynski, A, Pasteels, J L, Martinez, J, Kiss, R

“…Numerous data from published reports prove that the proliferation of gastrointestinal tumour cell lines are under the control of many hormones or growth…”
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Evidence of a direct relationship between the increase in the in vitro passage number of human non-small-cell-lung cancer primocultures and their chemosensitivity by Kruczynski, A, Kiss, R

“…A pharmacologically relevant modelling was attempted for screening of new molecules potentially active against non-small-cell lung cancers (NSCLCs). It was in…”
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DNA histogram typing in a series of 707 tumors of the central and peripheral nervous system by Salmon, I, Kruczynski, A, Camby, I, Levivier, M, Pasteels, J L, Brotchi, J, Kiss, R

“…The diagnostic value of ploidy level was investigated in a series of 707 tumors (from 707 patients) of the central and peripheral nervous system. The series…”
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The combination of the tetrazolium derivative reduction (MTT) and digital cell image analysis to monitor in vitro the cytotoxicity of anti-neoplastic drugs by Etievant, C, Kruczynski, A, Pauwels, O, Kiss, R

“…We assessed the in vitro drug-induced cytotoxicity by means of the rapid low-cost but weakly sensitive Thiazolyl blue (MTT) test, and the less rapid, higher…”
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Vinflunine, the latest Vinca alkaloid in clinical development : A review of its preclinical anticancer properties by Kruczynski, Anna, Hill, Bridget T.

“…Vinflunine is a new Vinca alkaloid uniquely fluorinated, by the use of superacid chemistry, in a little exploited region of the catharanthine moiety. In vitro…”
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Establishment of Novel Preclinical Melanoma Models Resistant to Vemurafenib by Robichon, C., Annereau, J.P., Gomes, B., Pillon, A., de Vries, L., Cussac, D., Meyer, N., Lamant, L., Kruczynski, A., Guilbaud, N.

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Spontaneous evolution of cytoplasmic lectin binding and nuclear size and deoxyribonucleic acid content in human colorectal cancers grafted onto nude mice by Jannot, M C, Kruczynski, A, Limouzy, A, Dangou, J M, Selves, J, Delsol, G, Martinez, J, Kiss, R

“…The development of certain biologic characteristics in human colorectal tumor xenografted onto nude mice are described with respect to their precocious…”
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Bcl-2 down-regulation and tubulin subtype composition are involved in resistance of ovarian cancer cells to vinflunine by Estève, Marie-Anne, Carré, Manon, Bourgarel-Rey, Véronique, Kruczynski, Anna, Raspaglio, Giuseppina, Ferlini, Cristiano, Braguer, Diane

“…Vinflunine, a new microtubule-targeting drug, has a marked antitumor activity in vitro and in vivo . Here, we studied the mechanisms mediating resistance to…”
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