Search Results - "Kruck, Theo P.A."

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease by Percy, Maire E., Kruck, Theo P.A., Pogue, Aileen I., Lukiw, Walter J.

“…In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was…”
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Synthesis of feralex a novel aluminum/iron chelating compound by Kruck, Theo P.A, Burrow, Timothy E

“…There is a need for in vivo applicable Fe 3+ and Al 3+ chelation compounds for use as medicines to treat toxic overload conditions of these ions. A novel…”
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Epidemic pathogenic selection: an explanation for hereditary hemochromatosis? by Moalem, Sharon, Percy, Maire E, Kruck, Theo P.A, Gelbart, Richard R

“…Hereditary hemochromatosis (HH) is a disorder associated with progressive iron overload and deposition in multiple organs. It is the most common inherited…”
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A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated τ of Alzheimer’s disease by Shin, Ryong-Woon, Kruck, Theo P.A., Murayama, Harunobu, Kitamoto, Tetsuyuki

“…Aluminum (Al(III)) and iron (Fe(III)) are reported to accumulate in neurofibrillary tangles of the Alzheimer’s disease (AD) brain. In these lesions Al (III)…”
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Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells by Alexandrov, Peter N, Zhao, Yuhai, Pogue, Aileen I, Tarr, Matthew A, Kruck, Theo P A, Percy, Maire E, Cui, Jian-Guo, Lukiw, Walter J

“…Disturbances in metal-ion transport, homeostasis, overload and metal ion-mediated catalysis are implicated in neurodegenerative conditions such as Alzheimer's…”
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Are hereditary hemochromatosis mutations involved in Alzheimer disease? by Moalem, Sharon, Percy, Maire E., Andrews, David F., Kruck, Theo P.A., Wong, Simon, Dalton, Arthur J., Mehta, Pankaj, Fedor, Bettye, Warren, Andrew C.

“…Mutations in the class I‐like major histocompatibility complex gene called HFE are associated with hereditary hemochromatosis (HHC), a disorder of excessive…”
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A Peptide Molecule Mimicking the Copper(II) Transport Site of Human Serum Albumin by Lau, Show-Jy, Kruck, Theo P.A., Sarkar, Bibudhendra

“…Diglycyl-l-histidine is a peptide molecule designed to mimic the specific Cu(II) transport site of human albumin. The equilibria involved in the…”
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P3-270: Metal ion-induced gene expression patterns in aging human brain cells in primary culture; implications for neurodegeneration and Alzheimer’s disease by Lukiw, Walter J., Cui, Jian-Guo, Bazan, Nicolas G., Zhao, Yuhai, Pogue, Aileen I.D., Tarr, Matthew A., Kruck, Theo P.A., Percy, Maire E., Alexandrov, Peter N.

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Dr. Crapper McLaughlan's colleague responds by Kruck, Theo P.A.

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Resolution of allelic and non-allelic variants of histone H1 by cation-exchange-hydrophilic-interaction chromatography by Mizzen, Craig A, Alpert, Andrew J, Lévesque, Lyne, Kruck, Theo.P.A, McLachlan, Donald R

“…A mixed-mode high-performance liquid chromatography (HPLC) method that resolves the six known non-allelic variants of chicken erythrocyte histone H1 is…”
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A predictor for side effects in patients with Alzheimer's disease treated with deferoxamine mesylate by Kruck, T P, Fisher, E A, McLachlan, D R

“…In a previously reported clinical trial, patients with Alzheimer's disease were treated with deferoxamine mesylate, which resulted in a 50% reduction in the…”
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Suppression of deferoxamine mesylate treatment-induced side effects by coadministration of isoniazid in a patient with Alzheimer's disease subject to aluminum removal by ionspecific chelation by Kruck, T P, Fisher, E A, McLachlan, D R

“…Deferoxamine treatment may produce serious side effects that can be eliminated by modification of treatment and by control of deferoxamine metabolism. A…”
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Acetylcholine receptor density and binding in murine dystrophy by Kruck, T P, Logan, D M

“…The concentration and binding characteristics of acetylcholine receptors (AChR) in sarcolemmal fractions from normal and dystrophic mice have been measured…”
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Neurotoxins from Bungarus fasciatus venom: a simple fractionation and separation of .alpha.- and .beta.-type neurotoxins and their partial characterization by Kruck, Theo P. A, Logan, David M

“…The crude venom of Bungarus fasciatus has been fractionated by column chromatography, and the fractionation characteristics of three different resins have been…”
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Development of an intravenous desferrioxamine mesylate treatment protocol for swine: monitoring of desferrioxamine and metabolites by high-performance liquid chromatography by Fisher, E A, McLachlan, D R, Kruck, T P, Mustard, R A

“…Desferrioxamine (DFO) metabolism and its pharmacokinetics were studied in a swine model using high-performance liquid chromatography. DFO and three…”
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High-performance liquid chromatographic analysis of desferrioxamine. Pharmacokinetic and metabolic studies by Kruck, T P, Teichert-Kuliszewska, K, Fisher, E, Kalow, W, McLachlan, D R

“…A high-performance liquid chromatographic method has been developed that permits determination and quantitation of desferrioxamine and metabolites as their…”
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