Search Results - "Kruchten, Patricia"

New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and Selectivity by Bey, Emmanuel, Marchais-Oberwinkler, Sandrine, Negri, Matthias, Kruchten, Patricia, Oster, Alexander, Klein, Tobias, Spadaro, Alessandro, Werth, Ruth, Frotscher, Martin, Birk, Barbara, Hartmann, Rolf W

“…17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is responsible for the catalytic reduction of weakly active E1 to highly potent E2. E2 stimulates the…”
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Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) by Bey, Emmanuel, Marchais-Oberwinkler, Sandrine, Werth, Ruth, Negri, Matthias, Al-Soud, Yaseen A, Kruchten, Patricia, Oster, Alexander, Frotscher, Martin, Birk, Barbara, Hartmann, Rolf W

“…17β-Estradiol (E2), the most potent female sex hormone, stimulates the growth of mammary tumors and endometriosis via activation of the estrogen receptor α…”
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New Drug-Like Hydroxyphenylnaphthol Steroidomimetics As Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Estrogen-Dependent Diseases by Marchais-Oberwinkler, Sandrine, Wetzel, Marie, Ziegler, Erika, Kruchten, Patricia, Werth, Ruth, Henn, Claudia, Hartmann, Rolf W, Frotscher, Martin

“…Inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a novel and attractive approach to reduce the local levels of the active estrogen…”
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Development of a biological screening system for the evaluation of highly active and selective 17β-HSD1-inhibitors as potential therapeutic agents by Kruchten, Patricia, Werth, Ruth, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W.

“…17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyses the intracellular conversion of oestrone (E1) to oestradiol (E2). E2 is known to be involved in…”
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Design, Synthesis, and Biological Evaluation of (Hydroxyphenyl)naphthalene and -quinoline Derivatives: Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) for the Treatment of Estrogen-Dependent Diseases by Frotscher, Martin, Ziegler, Erika, Marchais-Oberwinkler, Sandrine, Kruchten, Patricia, Neugebauer, Alexander, Fetzer, Ludivine, Scherer, Christiane, Müller-Vieira, Ursula, Messinger, Josef, Thole, Hubert, Hartmann, Rolf W

“…Human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the reduction of the weak estrogen estrone (E1) to the highly potent estradiol (E2). This…”
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Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases by Bey, Emmanuel, Marchais-Oberwinkler, Sandrine, Kruchten, Patricia, Frotscher, Martin, Werth, Ruth, Oster, Alexander, Algül, Oztekin, Neugebauer, Alexander, Hartmann, Rolf W.

“…A series of 19 azoles were synthesised and 17β-HSD1 inhibition determined. Compound 18 showed highest activity in cell free and T-47D assays, excellent…”
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Novel estrone mimetics with high 17β-HSD1 inhibitory activity by Oster, Alexander, Klein, Tobias, Werth, Ruth, Kruchten, Patricia, Bey, Emmanuel, Negri, Matthias, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W.

“…Estrone mimetics were synthesized and 17β-HSD1 inhibition was determined. Compound 12 showed high inhibitory activity, selectivity toward 17β-HSD2, ERα/ERβ and…”
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Substituted 6-Phenyl-2-naphthols. Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Design, Synthesis, Biological Evaluation, and Pharmacokinetics by Marchais-Oberwinkler, Sandrine, Kruchten, Patricia, Frotscher, Martin, Ziegler, Erika, Neugebauer, Alexander, Bhoga, Umadevi, Bey, Emmanuel, Müller-Vieira, Ursula, Messinger, Josef, Thole, Hubert, Hartmann, Rolf W

“…17β-Estradiol (E2) is implicated in the genesis and the development of estrogen-dependent diseases. Its concentration is mainly regulated by 17β-hydroxysteroid…”
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Selective inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17βHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells by Kruchten, Patricia, Werth, Ruth, Bey, Emmanuel, Oster, Alexander, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W.

“…The most potent estrogen estradiol (E2) plays a pivotal role in the initiation and progression of estrogen dependent diseases. 17β-Hydroxysteroid dehydrogenase…”
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Structure–activity study in the class of 6-(3′-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitors by Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Ziegler, Erika, Werth, Ruth, Kruchten, Patricia, Messinger, Josef, Thole, Hubert, Hartmann, Rolf W.

“…17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the transformation of estrone (E1) into the most potent estrogen, estradiol (E2), which stimulates…”
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The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) type 1 and type 2 by Al-Soud, Yaseen A., Bey, Emmanuel, Oster, Alexander, Marchais-Oberwinkler, Sandrine, Werth, Ruth, Kruchten, Patricia, Frotscher, Martin, Hartmann, Rolf W.

“…17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is responsible for the catalytic reduction of the weak estrogen estrone (E1) into the highly potent…”
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Development of a biological screening system for the evaluation of highly active and selective 17beta-HSD1-inhibitors as potential therapeutic agents by Kruchten, Patricia, Werth, Ruth, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W

“…17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyses the intracellular conversion of oestrone (E1) to oestradiol (E2). E2 is known to be involved…”
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Development of a biological screening system for the evaluation of highly active, selective 17(-HSD1-inhibitors as potential therapeutic agents by Kruchten, Patricia, Werth, Ruth, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W.

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Aging Reduces the Efficacy of Estrogen Substitution to Attenuate Cardiac Hypertrophy in Female Spontaneously Hypertensive Rats by Jazbutyte, Virginija, Hu, Kai, Kruchten, Patricia, Bey, Emmanuel, Maier, Sebastian K.G, Fritzemeier, Karl-Heinrich, Prelle, Katja, Hegele-Hartung, Christa, Hartmann, Rolf W, Neyses, Ludwig, Ertl, Georg, Pelzer, Theo

“…Clinical trials failed to show a beneficial effect of postmenopausal hormone replacement therapy, whereas experimental studies in young animals reported a…”
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Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors by Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Ziegler, Erika, Werth, Ruth, Kruchten, Patricia, Messinger, Josef, Thole, Hubert, Hartmann, Rolf W

“…17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyzes the transformation of estrone (E1) into the most potent estrogen, estradiol (E2), which…”
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The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-Hydroxysteroid Dehydrogenase (17beta-HSD) type 1 and type 2 by Al-Soud, Yaseen A, Bey, Emmanuel, Oster, Alexander, Marchais-Oberwinkler, Sandrine, Werth, Ruth, Kruchten, Patricia, Frotscher, Martin, Hartmann, Rolf W

“…17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) is responsible for the catalytic reduction of the weak estrogen estrone (E1) into the highly potent…”
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Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17p-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases by BEY, Emmanuel, MARCHAIS-OBERWINKLER, Sandrine, KRUCHTEN, Patricia, FROTSCHER, Martin, WERTH, Ruth, OSTER, Alexander, ALGÜL, Oztekin, NEUGEBAUER, Alexander, HARTMANN, Rolf W

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Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases by Frotscher, Martin, Ziegler, Erika, Marchais-Oberwinkler, Sandrine, Kruchten, Patricia, Neugebauer, Alexander, Fetzer, Ludivine, Scherer, Christiane, Müller-Vieira, Ursula, Messinger, Josef, Thole, Hubert, Hartmann, Rolf W

“…Human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyzes the reduction of the weak estrogen estrone (E1) to the highly potent estradiol (E2)…”
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Novel estrone mimetics with high 17beta-HSD1 inhibitory activity by Oster, Alexander, Klein, Tobias, Werth, Ruth, Kruchten, Patricia, Bey, Emmanuel, Negri, Matthias, Marchais-Oberwinkler, Sandrine, Frotscher, Martin, Hartmann, Rolf W

“…17Beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyzes the reduction of estrone into estradiol, which is the most potent estrogen in humans…”
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Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive rats. Commentary by HINOJOSA-LABORDE, Carmen, LINDSEY, Merry L, HARTMANN, Rolf W, NEYSES, Ludwig, ERTL, Georg, PELZER, Theo, JAZBUTYTE, Virginija, KAI HU, KRUCHTEN, Patricia, BEY, Emmanuel, MAIER, Sebastian K. G, FRITZEMEIER, Karl-Heinrich, PRELLE, Katja, HEGELE-HARTUNG, Christa

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