Search Results - "Krüger, Arne"

Discovery of Small-Molecule Allosteric Inhibitors of PfATC as Antimalarials by Wang, Chao, Zhang, Bidong, Krüger, Arne, Du, Xiaochen, Visser, Lidia, Dömling, Alexander S S, Wrenger, Carsten, Groves, Matthew R

“…The discovery and development of new drugs against malaria remain urgent. Aspartate transcarbamoylase (ATC) has been suggested to be a promising target for…”
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Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways by El-Merhie, Natalia, Krüger, Arne, Uliczka, Karin, Papenmeier, Stephanie, Roeder, Thomas, Rabe, Klaus F., Wagner, Christina, Angstmann, Hanna, Krauss-Etschmann, Susanne

“…E-cigarettes are heavily advertised as healthier alternative to common tobacco cigarettes, leading more and more women to switch from regular cigarettes to…”
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Transporter-Mediated Solutes Uptake as Drug Target in Plasmodium falciparum by Monteiro Júnior, Júlio César, Krüger, Arne, Palmisano, Giuseppe, Wrenger, Carsten

“…Malaria remains a public health problem with still more than half a million deaths annually. Despite ongoing efforts of many countries, malaria elimination has…”
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Aptamer Applications in Emerging Viral Diseases by Krüger, Arne, de Jesus Santos, Ana Paula, de Sá, Vanessa, Ulrich, Henning, Wrenger, Carsten

“…Aptamers are single-stranded DNA or RNA molecules which are submitted to a process denominated SELEX. SELEX uses reiterative screening of a random…”
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Plasmodium falciparum Acetyl-CoA Synthetase Is Essential for Parasite Intraerythrocytic Development and Chromatin Modification by Prata, Isadora Oliveira, Cubillos, Eliana Fernanda Galindo, Krüger, Arne, Barbosa, Deibs, Martins, Joaquim, Setubal, João Carlos, Wunderlich, Gerhard

“…The malaria parasite Plasmodium falciparum possesses a unique Acetyl-CoA Synthetase (PfACS), which provides acetyl moieties for different metabolic and…”
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Synthesis, design, and optimization of a potent and selective series of pyridylpiperazines as promising antimalarial agents by da Silva Oliveira, Douglas Davison, Paz, Franciarli, Brito, Nícolas Peterson Ferreira, Krüger, Arne, Martinho, Ana Clara Cassiano, Lapierre, Thibault Joseph William Jacques Dit, de Oliveira Souza, Felipe, Maltarollo, Vinícius G., Kronenberger, Thales, Mendes, Marina Sena, Nonato, Maria Cristina, Pilau, Eduardo Jorge, Wrenger, Carsten, Wunderlich, Gerhard, Rezende Júnior, Celso de Oliveira

“…An optimization of the pyridylpiperazine series against Plasmodium falciparum has been performed, exploring a structure-activity relationship carried out on…”
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Molecular Modeling Applied to Nucleic Acid-Based Molecule Development by Krüger, Arne, Zimbres, Flávia M, Kronenberger, Thales, Wrenger, Carsten

“…Molecular modeling by means of docking and molecular dynamics (MD) has become an integral part of early drug discovery projects, enabling the screening and…”
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Phosphatidylinositol-3-kinase (PI3K)/Akt Signaling is Functionally Essential in Myxoid Liposarcoma by Trautmann, Marcel, Cyra, Magdalene, Isfort, Ilka, Jeiler, Birte, Krüger, Arne, Grünewald, Inga, Steinestel, Konrad, Altvater, Bianca, Rossig, Claudia, Hafner, Susanne, Simmet, Thomas, Becker, Jessica, Åman, Pierre, Wardelmann, Eva, Huss, Sebastian, Hartmann, Wolfgang

“…Myxoid liposarcoma (MLS) is an aggressive soft-tissue tumor characterized by a specific reciprocal t(12;16) translocation resulting in expression of the…”
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Novel Highlight in Malarial Drug Discovery: Aspartate Transcarbamoylase by Wang, Chao, Krüger, Arne, Du, Xiaochen, Wrenger, Carsten, Groves, Matthew R

“…Malaria remains one of the most prominent and dangerous tropical diseases. While artemisinin and analogs have been used as first-line drugs for the past…”
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1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors by Tavares, Maurício T., Krüger, Arne, Yan, Sun L. Rei, Waitman, Karoline B., Gomes, Vinícius M., de Oliveira, Daffiny Sumam, Paz, Franciarli, Hilscher, Sebastian, Schutkowski, Mike, Sippl, Wolfgang, Ruiz, Claudia, Toledo, Mônica F. Z. J., Hassimotto, Neuza M. A., Machado-Neto, João A., Poso, Antti, Cameron, Michael D., Bannister, Thomas D., Palmisano, Giuseppe, Wrenger, Carsten, Kronenberger, Thales, Parise-Filho, Roberto

“…We report a series of 1,3-diphenylureido hydroxamate HDAC inhibitors evaluated against sensitive and drug-resistant P. falciparum strains. Compounds 8a–d show…”
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Modulating Fingolimod (FTY720) Anti-SARS-CoV‑2 Activity Using a PLGA-Based Drug Delivery System by Miranda, Renata Rank, Ferreira, Natália Noronha, Souza, Edmarcia Elisa de, Lins, Paula Maria Pincela, Ferreira, Leonardo Miziara Barboza, Krüger, Arne, Cardoso, Valéria Maria de Oliveira, Durigon, Edison Luiz, Wrenger, Carsten, Zucolotto, Valtencir

“…COVID-19 has resulted in more than 490 million people being infected worldwide, with over 6 million deaths by April 05th, 2022. Even though the development of…”
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High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum by Johannsen, Sandra, Gierse, Robin M., Krüger, Arne, Edwards, Rachel L., Nanna, Vittoria, Fontana, Anna, Zhu, Di, Masini, Tiziana, de Carvalho, Lais Pessanha, Poizat, Mael, Kieftenbelt, Bart, Hodge, Dana M., Alvarez, Sophie, Bunt, Daan, Lacour, Antoine, Shams, Atanaz, Meissner, Kamila Anna, de Souza, Edmarcia Elisa, Dröge, Melloney, van Vliet, Bernard, den Hartog, Jack, Hutter, Michael C., Held, Jana, Odom John, Audrey R., Wrenger, Carsten, Hirsch, Anna K. H.

“…In this study, we identified three novel compound classes with potent activity against Plasmodium falciparum, the most dangerous human malarial parasite…”
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Myocardial Dysfunction With Coronary Microembolization: Signal Transduction Through a Sequence of Nitric Oxide, Tumor Necrosis Factor-α, and Sphingosine by Thielmann, Matthias, Dörge, Hilmar, Martin, Claus, Belosjorow, Sergej, Schwanke, Uwe, van de Sand, Anita, Konietzka, Ina, Büchert, Astrid, Krüger, Arne, Schulz, Rainer, Heusch, Gerd

“…Coronary microembolization results in progressive myocardial dysfunction, with causal involvement of tumor necrosis factor-α (TNF-α). TNF-α uses a signal…”
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Mild Nijmegen breakage syndrome phenotype due to alternative splicing by Varon, Raymonda, Dutrannoy, Véronique, Weikert, Georg, Tanzarella, Caterina, Antoccia, Antonio, Stöckl, Lars, Spadoni, Emanuela, Krüger, Lars-Arne, Masi, Alessandra di, Sperling, Karl, Digweed, Martin, Maraschio, Paola

“…Hypomorphic mutations of the NBS1 gene are responsible for Nijmegen breakage syndrome (NBS), characterized by microcephaly, chromosomal instability,…”
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Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials by Wang, Chao, Zhang, Bidong, Krüger, Arne, Du, Xiaochen, Visser, Lidia, Dömling, Alexander S S, Wrenger, Carsten, Groves, Matthew R

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Simulation based optimization of torsional vibration dampers in automotive powertrains by Mall, Philipp, Fidlin, Alexander, Krüger, Arne, Groß, Heiko

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In utero exposure to cigarette smoke and effects across generations: A conference of animals on asthma by Hammer, Barbara, Wagner, Christina, Divac Rankov, Aleksandra, Reuter, Sebastian, Bartel, Sabine, Hylkema, Machteld N., Krüger, Arne, Svanes, Cecilie, Krauss‐Etschmann, Susanne

“…Summary Background The prevalence of asthma and chronic obstructive pulmonary disease (COPD) has risen markedly over the last decades and is reaching epidemic…”
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Insights in Chloroquine Action: Perspectives and Implications in Malaria and COVID‐19 by Pillat, Micheli Mainardi, Krüger, Arne, Guimarães, Lara Mendes Ferreira, Lameu, Claudiana, Souza, Edmarcia Elisa, Wrenger, Carsten, Ulrich, Henning

“…Malaria is a threat to human mankind and kills about half a million people every year. On the other hand, COVID‐19 resulted in several hundred thousand deaths…”
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Abstract B05: Myxoid liposarcoma: A molecular and clinicopathological analysis by targeted next-generation sequencing and fluorescence in situ hybridization by Trautmann, Marcel, Krüger, Arne, Jeiler, Birte, Bertling, Christian, Menzel, Jasmin, Cyra, Magdalene, Steinestel, Konrad, Grünewald, Inga, Åman, Pierre, Wardelmann, Eva, Huss, Sebastian, Hartmann, Wolfgang

“…Introduction: Myxoid liposarcoma (MLS) is the second most common type of liposarcoma, accounting for 30-35% of all LS cases. Over 90% of tumors are…”
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Sphingosine contributes to tumor necrosis factor-a-mediated contractile dysfunction in response to coronary microembolization by Thielmann, Matthias, Martin, Claus, Dörge, Hilmar, Belosjorow, Sergej, Schwanke, Uwe, Krüger, Arne, van de Sand, Anita, Konietzka, Ina, Schulz, Rainer, Heusch, Gerd

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