Search Results - "Krosl, Jana"

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia by Baccelli, Irène, Gareau, Yves, Lehnertz, Bernhard, Gingras, Stéphane, Spinella, Jean-François, Corneau, Sophie, Mayotte, Nadine, Girard, Simon, Frechette, Mélanie, Blouin-Chagnon, Valérie, Leveillé, Koryne, Boivin, Isabel, MacRae, Tara, Krosl, Jana, Thiollier, Clarisse, Lavallée, Vincent-Philippe, Kanshin, Evgeny, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bordeleau, Marie-Eve, Boucher, Geneviève, Roux, Philippe P., Lemieux, Sébastien, Tyers, Mike, Thibault, Pierre, Hébert, Josée, Marinier, Anne, Sauvageau, Guy

“…To identify therapeutic targets in acute myeloid leukemia (AML), we chemically interrogated 200 sequenced primary specimens. Mubritinib, a known ERBB2…”
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The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias by Lavallée, Vincent-Philippe, Baccelli, Irène, Krosl, Jana, Wilhelm, Brian, Barabé, Frédéric, Gendron, Patrick, Boucher, Geneviève, Lemieux, Sébastien, Marinier, Anne, Meloche, Sylvain, Hébert, Josée, Sauvageau, Guy

“…Guy Sauvageau, Josée Hébert and colleagues analyze exomes and transcriptomes in MLL -rearranged acute myeloid leukemias. They find frequent RAS pathway…”
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Genetic characterization of ABT-199 sensitivity in human AML by Bisaillon, Richard, Moison, Céline, Thiollier, Clarisse, Krosl, Jana, Bordeleau, Marie-Eve, Lehnertz, Bernhard, Lavallée, Vincent-Philippe, MacRae, Tara, Mayotte, Nadine, Labelle, Caroline, Boucher, Geneviève, Spinella, Jean-François, Boivin, Isabel, D’Angelo, Giovanni, Lavallée, Sylvie, Marinier, Anne, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy

“…Acute myeloid leukemias (AML) with mutations in the NPM1 gene (NPM1c+) represent a large AML subgroup with varying response to conventional treatment,…”
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Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors by Lavallée, Vincent-Philippe, Krosl, Jana, Lemieux, Sébastien, Boucher, Geneviève, Gendron, Patrick, Pabst, Caroline, Boivin, Isabel, Marinier, Anne, Guidos, Cynthia J., Meloche, Sylvain, Hébert, Josée, Sauvageau, Guy

“…In this study, we analyzed RNA-sequencing data of 14 samples characterized by biallelic CEBPA (CEBPAbi) mutations included in the Leucegene collection of 415…”
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The methyltransferase G9a regulates HoxA9-dependent transcription in AML by Lehnertz, Bernhard, Pabst, Caroline, Su, Le, Miller, Michelle, Liu, Feng, Yi, Lin, Zhang, Regan, Krosl, Jana, Yung, Eric, Kirschner, Jeanette, Rosten, Patty, Underhill, T Michael, Jin, Jian, Hébert, Josée, Sauvageau, Guy, Humphries, R Keith, Rossi, Fabio M

“…Chromatin modulators are emerging as attractive drug targets, given their widespread implication in human cancers and susceptibility to pharmacological…”
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Chemogenomic Landscape of RUNX1 -mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity by Simon, Laura, Lavallée, Vincent-Philippe, Bordeleau, Marie-Eve, Krosl, Jana, Baccelli, Irène, Boucher, Geneviève, Lehnertz, Bernhard, Chagraoui, Jalila, MacRae, Tara, Ruel, Réjean, Chantigny, Yves, Lemieux, Sébastien, Marinier, Anne, Hébert, Josée, Sauvageau, Guy

“…-mutated ( ) acute myeloid leukemia (AML) is associated with adverse outcome, highlighting the urgent need for a better genetic characterization of this AML…”
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RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity by Cellot, Sonia, Hope, Kristin J., Chagraoui, Jalila, Sauvageau, Martin, Deneault, Éric, MacRae, Tara, Mayotte, Nadine, Wilhelm, Brian T., Landry, Josette R., Ting, Stephen B., Krosl, Jana, Humphries, Keith, Thompson, Alexander, Sauvageau, Guy

“…Histone methylation is a dynamic and reversible process proposed to directly impact on stem cell fate. The Jumonji (JmjC) domain–containing family of…”
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Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway by Heinonen, Krista M, Vanegas, Juan Ruiz, Lew, Deborah, Krosl, Jana, Perreault, Claude

“…While the role of canonical (β-catenin-mediated) Wnt signaling in hematolymphopoiesis has been studied extensively, little is known of the potential importance…”
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In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein by Sauvageau, Guy, Krosl, Jana, Austin, Pamela, Beslu, Nathalie, Kroon, Evert, Humphries, R Keith

“…Hematopoietic stem cells (HSCs) can self-renew extensively after transplantation. The conditions supporting their in vitro expansion are still being defined…”
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Entinostat Prevents Leukemia Maintenance in a Collaborating Oncogene‐Dependent Model of Cytogenetically Normal Acute Myeloid Leukemia by Ramsey, Joanne M., Kettyle, Laura M.J., Sharpe, Daniel J., Mulgrew, Nuala M., Dickson, Glenda J., Bijl, Janet J., Austin, Pamela, Mayotte, Nadine, Cellot, Sonia, Lappin, Terence R.J., Zhang, Shu‐Dong, Mills, Ken I., Krosl, Jana, Sauvageau, Guy, Thompson, Alexander

“…The incidence of refractory acute myeloid leukemia (AML) is on the increase due in part to an aging population that fails to respond to traditional therapies…”
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AP-1 complex is effector of Hox-induced cellular proliferation and transformation by KROSL, Jana, SAUVAGEAU, Guy

“…Hox gene products, initially characterized as master regulators of embryonic patterning, are also required for proper functioning of adult tissues. There is…”
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Molecular interactions involved in HOXB4-induced activation of HSC self-renewal by Beslu, Nathalie, Krosl, Jana, Laurin, Mélanie, Mayotte, Nadine, Humphries, Keith R., Sauvageau, Guy

“…HOXB4 overexpression induces unique in vivo and in vitro expansion of hemopoietic stem cells (HSCs) without causing leukemia. Very little is known about the…”
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Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions by Fortier, Simon, Bilodeau, Mélanie, Macrae, Tara, Laverdure, Jean-Philippe, Azcoitia, Valeria, Girard, Simon, Chagraoui, Jalila, Ringuette, Nancy, Hébert, Josée, Krosl, Jana, Mayotte, Nadine, Sauvageau, Guy

“…Understanding the function of important DNA elements in mammalian stem cell genomes would be enhanced by the availability of deletion collections in which…”
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The Oncoprotein E2A-Pbx1a Collaborates with Hoxa9 To Acutely Transform Primary Bone Marrow Cells by Thorsteinsdottir, Unnur, Krosl, Jana, Kroon, Evert, Haman, André, Hoang, Trang, Sauvageau, Guy

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1 by KROSL, J, BABAN, S, KROSL, G, ROZENFELD, S, LARGMAN, C, SAUVAGEAU, G

“…The products of PBX homeobox genes, which were initially discovered in reciprocal translocations occurring in human leukemias, have been shown to cooperate in…”
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The Competitive Nature of HOXB4-Transduced HSC Is Limited by PBX1 by Krosl, Jana, Beslu, Nathalie, Mayotte, Nadine, Humphries, R.Keith, Sauvageau, Guy

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GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo by Pabst, Caroline, Bergeron, Anne, Lavallée, Vincent-Philippe, Yeh, Jonathan, Gendron, Patrick, Norddahl, Gudmundur L., Krosl, Jana, Boivin, Isabel, Deneault, Eric, Simard, Jessica, Imren, Suzan, Boucher, Geneviève, Eppert, Kolja, Herold, Tobias, Bohlander, Stefan K., Humphries, Keith, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy, Barabé, Frédéric

“…Acute myeloid leukemia (AML) is a genetically heterogeneous hematologic malignancy, which is initiated and driven by a rare fraction of leukemia stem cells…”
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Identification of small molecules that support human leukemia stem cell activity ex vivo by Pabst, Caroline, Krosl, Jana, Fares, Iman, Boucher, Geneviève, Ruel, Réjean, Marinier, Anne, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy

“…This paper reports conditions for the in vitro culture of human leukemia stem cells, which should enable basic studies as well as chemical screens on these…”
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A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia by Simon, Camille, Chagraoui, Jalila, Krosl, Jana, Gendron, Patrick, Wilhelm, Brian, Lemieux, Sébastien, Boucher, Geneviève, Chagnon, Pierre, Drouin, Simon, Lambert, Raphaëlle, Rondeau, Claude, Bilodeau, Annie, Lavallée, Sylvie, Sauvageau, Martin, Hébert, Josée, Sauvageau, Guy

“…In this study, we show the high frequency of spontaneous γδ T-cell leukemia (T-ALL) occurrence in mice with biallelic deletion of enhancer of zeste homolog 2…”
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Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin by Lavallée, Vincent-Philippe, Chagraoui, Jalila, MacRae, Tara, Marquis, Miriam, Bonnefoy, Arnaud, Krosl, Jana, Lemieux, Sébastien, Marinier, Anne, Pabst, Caroline, Rivard, Georges-Étienne, Hébert, Josée, Sauvageau, Guy

“…Acute promyelocytic leukemia (APL) is a medical emergency because of associated lethal early bleeding, a condition preventable by prompt diagnosis and…”
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