Search Results - "Kros, Johan M"

Diffuse Infiltrating Oligodendroglioma and Astrocytoma by van den Bent, Martin J, Smits, Marion, Kros, Johan M, Chang, Susan M

“…The new 2016 WHO brain tumor classification defines different diffuse gliomas primarily according to the presence or absence of IDH mutations ( IDH-mt) and…”
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Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO) by Soffietti, Riccardo, Abacioglu, Ufuk, Baumert, Brigitta, Combs, Stephanie E, Kinhult, Sara, Kros, Johan M, Marosi, Christine, Metellus, Philippe, Radbruch, Alexander, Villa Freixa, Salvador S, Brada, Michael, Carapella, Carmine M, Preusser, Matthias, Le Rhun, Emilie, Rudà, Roberta, Tonn, Joerg C, Weber, Damien C, Weller, Michael

“…The management of patients with brain metastases has become a major issue due to the increasing frequency and complexity of the diagnostic and therapeutic…”
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International Society of Neuropathology-Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading by Louis, David N., Perry, Arie, Burger, Peter, Ellison, David W., Reifenberger, Guido, von Deimling, Andreas, Aldape, Kenneth, Brat, Daniel, Collins, V. Peter, Eberhart, Charles, Figarella-Branger, Dominique, Fuller, Gregory N., Giangaspero, Felice, Giannini, Caterina, Hawkins, Cynthia, Kleihues, Paul, Korshunov, Andrey, Kros, Johan M., Beatriz Lopes, M., Ng, Ho-Keung, Ohgaki, Hiroko, Paulus, Werner, Pietsch, Torsten, Rosenblum, Marc, Rushing, Elisabeth, Soylemezoglu, Figen, Wiestler, Otmar, Wesseling, Pieter

“…Major discoveries in the biology of nervous system tumors have raised the question of how non‐histological data such as molecular information can be…”
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The impact of surgery in molecularly defined low-grade glioma: an integrated clinical, radiological, and molecular analysis by Wijnenga, Maarten M J, French, Pim J, Dubbink, Hendrikus J, Dinjens, Winand N M, Atmodimedjo, Peggy N, Kros, Johan M, Smits, Marion, Gahrmann, Renske, Rutten, Geert-Jan, Verheul, Jeroen B, Fleischeuer, Ruth, Dirven, Clemens M F, Vincent, Arnaud J P E, van den Bent, Martin J

“…Extensive resections in low-grade glioma (LGG) are associated with improved overall survival (OS). However, World Health Organization (WHO) classification of…”
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Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951 by VAN DEN BENT, Martin J, BRANDES, Alba A, SIPOS, László, ENTING, Roelien H, FRENCH, Pim J, DINJENS, Winand N. M, VECHT, Charles J, ALLGEIER, Anouk, LACOMBE, Denis, GORLIA, Thierry, HOANG-XUAN, Khê, TAPHOORN, Martin J. B, KROS, Johan M, KOUWENHOVEN, Mathilde C. M, DELATTRE, Jean-Yves, BERNSEN, Hans J. J. A, FRENAY, Marc, TIJSSEN, Cees C, GRISOLD, Wolfgang

“…Anaplastic oligodendroglioma are chemotherapy-sensitive tumors. We now present the long-term follow-up findings of a randomized phase III study on the addition…”
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A clinical perspective on the 2016 WHO brain tumor classification and routine molecular diagnostics by van den Bent, Martin J, Weller, Michael, Wen, Patrick Y, Kros, Johan M, Aldape, Ken, Chang, Susan

“…The 2007 World Health Organization (WHO) classification of brain tumors did not use molecular abnormalities as diagnostic criteria. Studies have shown that…”
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Changes in the EGFR amplification and EGFRvIII expression between paired primary and recurrent glioblastomas by van den Bent, Martin J, Gao, Ya, Kerkhof, Melissa, Kros, Johan M, Gorlia, Thierry, van Zwieten, Kitty, Prince, Jory, van Duinen, Sjoerd, Sillevis Smitt, Peter A, Taphoorn, Martin, French, Pim J

“…The efficacy of novel targeted therapies is often tested at the time of tumor recurrence. However, for glioblastoma (GBM) patients, surgical resections at…”
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Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial by Dubbink, Hendrikus J, Atmodimedjo, Peggy N, Kros, Johan M, French, Pim J, Sanson, Marc, Idbaih, Ahmed, Wesseling, Pieter, Enting, Roelien, Spliet, Wim, Tijssen, Cees, Dinjens, Winand N M, Gorlia, Thierry, van den Bent, Martin J

“…Histopathological diagnosis of diffuse gliomas is subject to interobserver variation and correlates modestly with major prognostic and predictive molecular…”
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Molecular and clinical heterogeneity of adult diffuse low-grade IDH wild-type gliomas: assessment of TERT promoter mutation and chromosome 7 and 10 copy number status allows superior prognostic stratification by Wijnenga, Maarten M. J., Dubbink, Hendrikus J., French, Pim J., Synhaeve, Nathalie E., Dinjens, Winand N. M., Atmodimedjo, Peggy N., Kros, Johan M., Dirven, Clemens M. F., Vincent, Arnaud J. P. E., van den Bent, Martin J.

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Low-grade glioma harbors few CD8 T cells, which is accompanied by decreased expression of chemo-attractants, not immunogenic antigens by Weenink, Bas, Draaisma, Kaspar, Ooi, Han Z., Kros, Johan M., Sillevis Smitt, Peter A. E., Debets, Reno, French, Pim J.

“…In multiple tumor types, prediction of response to immune therapies relates to the presence, distribution and activation state of tumor infiltrating…”
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Randomized Phase II Trial of Erlotinib Versus Temozolomide or Carmustine in Recurrent Glioblastoma: EORTC Brain Tumor Group Study 26034 by VAN DEN BENT, Martin J, BRANDES, Alba A, ARMAND, Jean-Paul, TAPHOORN, Martin J. B, TOSONI, Alicia, KLETZL, Heidemarie, KLUGHAMMER, Barbara, LACOMBE, Denis, GORLIA, Thierry, RAMPLING, Roy, KOUWENHOVEN, Mathilde C. M, KROS, Johan M, CARPENTIER, Antoine F, CLEMENT, Paul M, FRENAY, Marc, CAMPONE, Mario, BAURAIN, Jean-Francois

“…Approximately 50% of glioblastomas (GBMs) are characterized by overexpression of the epidermal growth factor receptor (EGFR) and EGFR gene amplification. In…”
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Improving the characterization of endothelial progenitor cell subsets by an optimized FACS protocol by Huizer, Karin, Mustafa, Dana A M, Spelt, J Clarissa, Kros, Johan M, Sacchetti, Andrea

“…The characterization of circulating endothelial progenitor cells (EPCs) is fundamental to any study related to angiogenesis. Unfortunately, current literature…”
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Unlocking molecular mechanisms and identifying druggable targets in matched-paired brain metastasis of breast and lung cancers by Najjary, Shiva, de Koning, Willem, Kros, Johan M, Mustafa, Dana A M

“…The incidence of brain metastases in cancer patients is increasing, with lung and breast cancer being the most common sources. Despite advancements in targeted…”
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Efficacy and safety of peptide receptor radionuclide therapy with [177Lu]Lu-DOTA-TATE in 15 patients with progressive treatment-refractory meningioma by Minczeles, Noémie S., Bos, Eelke M., de Leeuw, Reinoud C., Kros, Johan M., Konijnenberg, Mark W., Bromberg, Jacoline E. C., de Herder, Wouter W., Dirven, Clemens M. F., Hofland, Johannes, Brabander, Tessa

“…Purpose There is no evidence-based systemic therapy for patients with progressive meningiomas for whom surgery or external radiotherapy is no longer an option…”
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CMTM3 (CKLF-Like Marvel Transmembrane Domain 3) Mediates Angiogenesis by Regulating Cell Surface Availability of VE-Cadherin in Endothelial Adherens Junctions by Chrifi, Ihsan, Louzao-Martinez, Laura, Brandt, Maarten, van Dijk, Christian G M, Burgisser, Petra, Zhu, Changbin, Kros, Johan M, Duncker, Dirk J, Cheng, Caroline

“…Decrease in VE-cadherin adherens junctions reduces vascular stability, whereas disruption of adherens junctions is a requirement for neovessel sprouting during…”
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Metabolic changes related to the IDH1 mutation in gliomas preserve TCA‐cycle activity: An investigation at the protein level by Dekker, Lennard J. M., Wu, Suying, Jurriëns, Cherise, Mustafa, Dana A. N., Grevers, Frederieke, Burgers, Peter C., Sillevis Smitt, Peter A. E., Kros, Johan M., Luider, Theo M.

“…The discovery of the IDH1 R132H (IDH1 mut) mutation in low‐grade glioma and the associated change in function of the IDH1 enzyme has increased the interest in…”
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MGMT Promoter Methylation Is Prognostic but Not Predictive for Outcome to Adjuvant PCV Chemotherapy in Anaplastic Oligodendroglial Tumors: A Report From EORTC Brain Tumor Group Study 26951 by van den Bent, Martin J, Dubbink, Hendrikus J, Sanson, Marc, van der Lee-Haarloo, Cathleen R, Hegi, Monika, Jeuken, Judith W M, Ibdaih, Ahmed, Brandes, Alba A, Taphoorn, Martin J B, Frenay, Marc, Lacombe, Denis, Gorlia, Thierry, Dinjens, Winand N M, Kros, Johan M

“…O6-methylguanine-methyltransferase (MGMT) promoter methylation has been shown to predict survival of patients with glioblastomas if temozolomide is added to…”
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Tumor lineage-specific immune response in brain metastatic disease: opportunities for targeted immunotherapy regimen? by Najjary, Shiva, Kros, Johan M, de Koning, Willem, Vadgama, Disha, Lila, Karishma, Wolf, Janina, Mustafa, Dana A M

“…Metastases in the brain are the most severe and devastating complication of cancer. The incidence of brain metastasis is increasing. Therefore, the need of…”
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Novel Antibody-Peptide Binding Assay Indicates Presence of Immunoglobulins against EGFR Phospho-Site S1166 in High-Grade Glioma by Zeneyedpour, Lona, Stingl, Christoph, Kros, Johan M, Sillevis Smitt, Peter A E, Luider, Theo M

“…We investigated the feasibility of detecting the presence of specific autoantibodies against potential tumor-associated peptide antigens by enriching these…”
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Defining EGFR amplification status for clinical trial inclusion by French, Pim J, Eoli, Marica, Sepulveda, Juan Manuel, de Heer, Iris, Kros, Johan M, Walenkamp, Annemiek, Frenel, Jean-Sebastien, Franceschi, Enrico, Clement, Paul M, Weller, Michael, Ansell, Peter, Looman, Jim, Bain, Earle, Morfouace, Marie, Gorlia, Thierry, van den Bent, Martin

“…Precision medicine trials targeting the epidermal growth factor receptor (EGFR) in glioblastoma patients require selection for EGFR-amplified tumors. However,…”
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