Search Results - "Kroon, Evert"

Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes by Keymeulen, Bart, De Groot, Kaat, Jacobs-Tulleneers-Thevissen, Daniel, Thompson, David M., Bellin, Melena D., Kroon, Evert J., Daniels, Mark, Wang, Richard, Jaiman, Manasi, Kieffer, Timothy J., Foyt, Howard L., Pipeleers, Daniel

“…Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from human embryonic stem cells found that…”
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Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device by Shapiro, A.M. James, Thompson, David, Donner, Thomas W., Bellin, Melena D., Hsueh, Willa, Pettus, Jeremy, Wilensky, Jon, Daniels, Mark, Wang, Richard M., Brandon, Eugene P., Jaiman, Manasi S., Kroon, Evert J., D’Amour, Kevin A., Foyt, Howard L.

“…These preliminary data from an ongoing first-in-human phase 1/2, open-label study provide proof-of-concept that pluripotent stem cell-derived pancreatic…”
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Insulin‐Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo by Agulnick, Alan D., Ambruzs, Dana M., Moorman, Mark A., Bhoumik, Anindita, Cesario, Rosemary M., Payne, Janice K., Kelly, Jonathan R., Haakmeester, Carl, Srijemac, Robert, Wilson, Alistair Z., Kerr, Justin, Frazier, Mauro A., Kroon, Evert J., D'Amour, Kevin A.

“…This paper describes a new protocol for producing insulin‐producing cells in vitro that represents another potential cell source for a diabetes cell therapy…”
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Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo by Richardson, Mike, Young, Holly, Kadoya, Kuniko, Baetge, Emmanuel E, Kelly, Olivia G, Carpenter, Melissa K, Smart, Nora G, Bang, Anne G, Eliazer, Susan, D'Amour, Kevin A, Agulnick, Alan D, Kroon, Evert, Martinson, Laura A, Cunningham, Justine

“…Development of a cell therapy for diabetes would be greatly aided by a renewable supply of human β-cells. Here we show that pancreatic endoderm derived from…”
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Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells by Baetge, Emmanuel E, D'Amour, Kevin A, Bang, Anne G, Eliazer, Susan, Kelly, Olivia G, Agulnick, Alan D, Smart, Nora G, Moorman, Mark A, Kroon, Evert, Carpenter, Melissa K

“…Of paramount importance for the development of cell therapies to treat diabetes is the production of sufficient numbers of pancreatic endocrine cells that…”
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Efficient differentiation of human embryonic stem cells to definitive endoderm by Baetge, Emmanuel E, D'Amour, Kevin A, Agulnick, Alan D, Eliazer, Susan, Kelly, Olivia G, Kroon, Evert

“…The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety of organs has generated much excitement over the possible use…”
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Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells by Kelly, Olivia G, Chan, Man Yin, Martinson, Laura A, Kadoya, Kuniko, Ostertag, Traci M, Ross, Kelly G, Richardson, Mike, Carpenter, Melissa K, D'Amour, Kevin A, Kroon, Evert, Moorman, Mark, Baetge, Emmanuel E, Bang, Anne G

“…Kelly et al . describe antibodies for purifying two progenitor populations that arise during the differentiation of human embryonic stem cells to pancreatic…”
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Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control by Robert, Thomas, De Mesmaeker, Ines, Stangé, Geert M., Suenens, Krista G., Ling, Zhidong, Kroon, Evert J., Pipeleers, Daniel G.

“…Human stem cells represent a potential source for implants that replace the depleted functional beta cell mass (FBM) in diabetes patients. Human embryonic stem…”
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Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells by Xie, Ruiyu, Everett, Logan J., Lim, Hee-Woong, Patel, Nisha A., Schug, Jonathan, Kroon, Evert, Kelly, Olivia G., Wang, Allen, D’Amour, Kevin A., Robins, Allan J., Won, Kyoung-Jae, Kaestner, Klaus H., Sander, Maike

“…Embryonic development is characterized by dynamic changes in gene expression, yet the role of chromatin remodeling in these cellular transitions remains…”
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A scalable system for production of functional pancreatic progenitors from human embryonic stem cells by Schulz, Thomas C, Young, Holly Y, Agulnick, Alan D, Babin, M Josephine, Baetge, Emmanuel E, Bang, Anne G, Bhoumik, Anindita, Cepa, Igor, Cesario, Rosemary M, Haakmeester, Carl, Kadoya, Kuniko, Kelly, Jonathan R, Kerr, Justin, Martinson, Laura A, McLean, Amanda B, Moorman, Mark A, Payne, Janice K, Richardson, Mike, Ross, Kelly G, Sherrer, Eric S, Song, Xuehong, Wilson, Alistair Z, Brandon, Eugene P, Green, Chad E, Kroon, Evert J, Kelly, Olivia G, D'Amour, Kevin A, Robins, Allan J

“…Development of a human embryonic stem cell (hESC)-based therapy for type 1 diabetes will require the translation of proof-of-principle concepts into a…”
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196-LB: Stem Cell–Derived Islet Replacement Therapy (VC-02) Demonstrates Production of C-Peptide in Patients with Type 1 Diabetes (T1D) and Hypoglycemia Unawareness by KEYMEULEN, BART, JACOBS-TULLENEERS-THEVISSEN, DANIEL, KROON, EVERT J., JAIMAN, MANASI S., DANIELS, MARK, WANG, RICHARD, PIPELEERS, DANIEL, D’AMOUR, KEVIN, FOYT, HOWARD L.

“…Patients with T1D exhibit a major loss in beta cell mass, associated with low or undetectable circulating markers of beta cell function. C-peptide serves as a…”
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Immunogenicity of human embryonic stem cell-derived beta cells by van der Torren, Cornelis R., Zaldumbide, Arnaud, Duinkerken, Gaby, Brand-Schaaf, Simone H., Peakman, Mark, Stangé, Geert, Martinson, Laura, Kroon, Evert, Brandon, Eugene P., Pipeleers, Daniel, Roep, Bart O.

“…Aims/hypothesis To overcome the donor shortage in the treatment of advanced type 1 diabetes by islet transplantation, human embryonic stem cells (hESCs) show…”
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In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein by Sauvageau, Guy, Krosl, Jana, Austin, Pamela, Beslu, Nathalie, Kroon, Evert, Humphries, R Keith

“…Hematopoietic stem cells (HSCs) can self-renew extensively after transplantation. The conditions supporting their in vitro expansion are still being defined…”
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Defining Roles for HOX and MEIS1 Genes in Induction of Acute Myeloid Leukemia by Thorsteinsdottir, Unnur, Kroon, Evert, Jerome, Lori, Blasi, Francesco, Sauvageau, Guy

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Initial Clinical Evaluation of VC-01TM Combination Product—A Stem Cell–Derived Islet Replacement for Type 1 Diabetes (T1D) by HENRY, ROBERT R., PETTUS, JEREMY, WILENSKY, JON, SHAPIRO, A.M. JAMES, SENIOR, PETER A., ROEP, BART, WANG, RICHARD, KROON, EVERT J., SCOTT, MICHAEL, D'AMOUR, KEVIN, FOYT, HOWARD L.

“…VC-01 is a novel cell replacement therapy being developed as a potential long-term diabetes therapy to more effectively control glycemia, reduce hypoglycemia…”
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Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model by Iwasaki, Masayuki, Kuwata, Takeshi, Yamazaki, Yukari, Jenkins, Nancy A., Copeland, Neal G., Osato, Motomi, Ito, Yoshiaki, Kroon, Evert, Sauvageau, Guy, Nakamura, Takuro

“…The chromosomal translocation t(7; 11)(p15;p15), observed in human myeloid leukemia, results in a NUP98 and HOXA9 gene fusion. We generated a transgenic mouse…”
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The Oncoprotein E2A-Pbx1a Collaborates with Hoxa9 To Acutely Transform Primary Bone Marrow Cells by Thorsteinsdottir, Unnur, Krosl, Jana, Kroon, Evert, Haman, André, Hoang, Trang, Sauvageau, Guy

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Composition and function of macroencapsulated human embryonic stem cell-derived implants: comparison with clinical human islet cell grafts by Motté, Evi, Szepessy, Edit, Suenens, Krista, Stangé, Geert, Bomans, Myriam, Jacobs-Tulleneers-Thevissen, Daniel, Ling, Zhidong, Kroon, Evert, Pipeleers, Daniel

“…β-Cells generated from large-scale sources can overcome current shortages in clinical islet cell grafts provided that they adequately respond to metabolic…”
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Oncogenic interaction between BCR-ABL andNUP98-HOXA9 demonstrated by the use of an in vitro purging culture system by Mayotte, Nadine, Roy, Denis-Claude, Yao, Jing, Kroon, Evert, Sauvageau, Guy

“…Chronic myelogenous leukemia (CML) is a clonal stem cell disease caused by the BCR-ABL oncoprotein and is characterized, in its early phase, by excessive…”
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Disparate Tissue-specific Expression of Members of the Tissue Kallikrein Multigene Family of the Rat by MacDonald, Raymond J., Southard-Smith, E. Michelle, Kroon, Evert

“…To understand the regulatory diversity of the rat family of linked kallikrein genes, we have assayed the expression of family members in 20 major organs…”
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