Search Results - "Kronenthal, David"

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    Scalable Synthesis of the Potent HIV Inhibitor BMS-986001 by Non-Enzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) by Ortiz, Adrian, Benkovics, Tamas, Beutner, Gregory L., Shi, Zhongping, Bultman, Michael, Nye, Jeffrey, Sfouggatakis, Chris, Kronenthal, David R.

    Published in Angewandte Chemie International Edition (08-06-2015)
    “…Described herein is the synthesis of BMS‐986001 by employing two novel organocatalytic transformations: 1) a highly selective pyranose to furanose ring…”
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    Journal Article
  2. 2

    Development of a Practical Synthesis of a Farnesyltransferase Inhibitor by Shi, Zhongping, Fan, Junying, Kronenthal, David R, Mudryk, Boguslaw M

    Published in Organic process research & development (16-11-2018)
    “…The development of a new and practical synthesis for a farnesyltransferase inhibitor 1 is described. The new route started from 2-nitro-5-cyanotoluene (9) and…”
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  3. 3

    The Effect of Additives on the Zinc Carbenoid-Mediated Cyclopropanation of a Dihydropyrrole by Ramirez, Antonio, Truc, Vu Chi, Lawler, Michael, Ye, Yun K, Wang, Jianji, Wang, Chenchi, Chen, Steven, Laporte, Thomas, Liu, Nian, Kolotuchin, Sergei, Jones, Scott, Bordawekar, Shailendra, Tummala, Srinivas, Waltermire, Robert E, Kronenthal, David

    Published in Journal of organic chemistry (03-07-2014)
    “…The synthesis of a key intermediate in the preparation of oral antidiabetic drug Saxagliptin is discussed with an emphasis on the challenges posed by the…”
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  4. 4

    Scalable Synthesis of the Potent HIV Inhibitor BMS-986001 by Non-Enzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) by Ortiz, Adrian, Benkovics, Tamas, Beutner, Gregory L., Shi, Zhongping, Bultman, Michael, Nye, Jeffrey, Sfouggatakis, Chris, Kronenthal, David R.

    Published in Angewandte Chemie (08-06-2015)
    “…Described herein is the synthesis of BMS‐986001 by employing two novel organocatalytic transformations: 1) a highly selective pyranose to furanose ring…”
    Get full text
    Journal Article
  5. 5

    A Stereoselective Synthesis of BMS-262084, an Azetidinone-Based Tryptase Inhibitor by Qian, Xinhua, Zheng, Bin, Burke, Brian, Saindane, Manohar T, Kronenthal, David R

    Published in Journal of organic chemistry (31-05-2002)
    “…A highly stereoselective synthesis of the novel tryptase inhibitor BMS-262084 was developed. Key to this synthesis was the discovery and development of a…”
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    A Practical Synthesis of l-Valyl-pyrrolidine-(2R)-boronic Acid:  Efficient Recycling of the Costly Chiral Auxiliary (+)-Pinanediol by Gibson, Frank S, Singh, Ambarish K, Soumeillant, Maxime C, Manchand, Percy S, Humora, Michael, Kronenthal, David R

    Published in Organic process research & development (01-11-2002)
    “…A practical synthesis of l-valyl-pyrrolidine-(2R)-boronic acid (1) is detailed. A previously disclosed synthesis of 1 (Snow, R.; Kelly, T. R.; Adams, J.;…”
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    Chemical and Enzymatic Resolution of (R,S)-N-(tert-Butoxycarbonyl)-3-hydroxymethylpiperidine by Goswami, Animesh, Howell, Jeffrey M, Hua, Edward Y, Mirfakhrae, K. David, Soumeillant, Maxime C, Swaminathan, Shankar, Qian, Xinhua, Quiroz, Fernando A, Vu, Truc C, Wang, Xuebao, Zheng, Bin, Kronenthal, David R, Patel, Ramesh N

    Published in Organic process research & development (01-07-2001)
    “…(S)-N-(tert-Butoxycarbonyl)-3-hydroxymethylpiperidine 1 was made from (R,S)-3-hydroxymethylpiperidine 2 via fractional crystallization of the corresponding…”
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    One-Carbon Chain Extension of Esters to α-Chloroketones:  A Safer Route without Diazomethane by Wang, Dengjin, Schwinden, Mark D, Radesca, Lilian, Patel, Bharat, Kronenthal, David, Huang, Ming-Hsing, Nugent, William A

    Published in Journal of organic chemistry (05-03-2004)
    “…The reaction of a variety of methyl esters with dimethylsulfoxonium methylide at 0−25 °C affords the chain-extended β-keto dimethylsulfoxonium ylides…”
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    Synthesis of (±)-camptothecin using a [3+2] nitrone cycloaddition to construct the CDE ring moiety by Yu, Jurong, DePue, Jeffrey, Kronenthal, David

    Published in Tetrahedron letters (20-09-2004)
    “…A novel synthesis to camptothecin is described. A Friedlander condensation of o-aminobenzaldehye with tricylclic ketone affords camptothecin after further…”
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    Enzymatic synthesis of L-6-hydroxynorleucine by Hanson, R L, Schwinden, M D, Banerjee, A, Brzozowski, D B, Chen, B C, Patel, B P, McNamee, C G, Kodersha, G A, Kronenthal, D R, Patel, R N, Szarka, L J

    Published in Bioorganic & medicinal chemistry (01-10-1999)
    “…L-6-Hydroxynorleucine, a key chiral intermediate used for synthesis of a vasopeptidase inhibitor, was prepared in 89% yield and > 99% optical purity by…”
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    Reaction of electron-deficient N-sulfinylanilines with chiral α-hydroxy acids: a new process for the synthesis of enantiomerically pure α-hydroxy amides by Chidambaram, Ramakrishnan, Zhu, Jason, Penmetsa, Kumar, Kronenthal, David, Kant, Joydeep

    Published in Tetrahedron letters (2000)
    “…A practical procedure to prepare enantiomerically pure α-hydroxy amides from chiral α-hydroxy acids and electron-deficient anilines via N-sulfinylaniline…”
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    A Practical Synthesis of the RARγ Agonist, BMS-270394 by Chidambaram, Ramakrishnan, Kant, Joydeep, Zhu, Jason, Lajeunesse, Jean, Sirard, Pierre, Ermann, Peter, Schierling, Peter, Lee, Peter, Kronenthal, David

    Published in Organic process research & development (01-09-2002)
    “…A novel synthesis of 1 (BMS-270394), a nuclear retinoic acid receptor (RARγ) agonist, is reported. The synthesis includes an enantioselective reduction of…”
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