Search Results - "Kronenthal, David"
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Scalable Synthesis of the Potent HIV Inhibitor BMS-986001 by Non-Enzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT)
Published in Angewandte Chemie International Edition (08-06-2015)“…Described herein is the synthesis of BMS‐986001 by employing two novel organocatalytic transformations: 1) a highly selective pyranose to furanose ring…”
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2
Development of a Practical Synthesis of a Farnesyltransferase Inhibitor
Published in Organic process research & development (16-11-2018)“…The development of a new and practical synthesis for a farnesyltransferase inhibitor 1 is described. The new route started from 2-nitro-5-cyanotoluene (9) and…”
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3
The Effect of Additives on the Zinc Carbenoid-Mediated Cyclopropanation of a Dihydropyrrole
Published in Journal of organic chemistry (03-07-2014)“…The synthesis of a key intermediate in the preparation of oral antidiabetic drug Saxagliptin is discussed with an emphasis on the challenges posed by the…”
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4
Scalable Synthesis of the Potent HIV Inhibitor BMS-986001 by Non-Enzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT)
Published in Angewandte Chemie (08-06-2015)“…Described herein is the synthesis of BMS‐986001 by employing two novel organocatalytic transformations: 1) a highly selective pyranose to furanose ring…”
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5
A Stereoselective Synthesis of BMS-262084, an Azetidinone-Based Tryptase Inhibitor
Published in Journal of organic chemistry (31-05-2002)“…A highly stereoselective synthesis of the novel tryptase inhibitor BMS-262084 was developed. Key to this synthesis was the discovery and development of a…”
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6
Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632
Published in Organic process research & development (01-05-2002)“…Development of an efficient and scalable process for the human immunodeficiency virus (HIV) protease inhibitor BMS-232632…”
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7
Efficient Asymmetric Synthesis of the Vasopeptidase Inhibitor BMS-189921
Published in Organic letters (21-08-2003)“…An efficient asymmetric synthesis of the vasopeptidase inhibitor BMS-189921 was accomplished. Two short enantioselective syntheses of the common key…”
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8
Synthesis of 6-Cyano-2,2-dimethyl-2H-1-benzopyran and Other Substituted 2,2-Dimethyl-2H-1-benzopyrans
Published in Journal of organic chemistry (01-06-1995)Get full text
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9
Regioselective enzymatic aminoacylation of lobucavir to give an intermediate for lobucavir prodrug
Published in Bioorganic & medicinal chemistry (01-12-2000)“…Synthesis of lobucavir prodrug, L-valine, [(1 S,2 R,3 R)-3-(2-amino-1,6-dihydro-6-oxo-9 H-purin-9-yl)-2-(hydroxymethyl)cyclobutyl]methyl ester…”
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10
A Practical Synthesis of l-Valyl-pyrrolidine-(2R)-boronic Acid: Efficient Recycling of the Costly Chiral Auxiliary (+)-Pinanediol
Published in Organic process research & development (01-11-2002)“…A practical synthesis of l-valyl-pyrrolidine-(2R)-boronic acid (1) is detailed. A previously disclosed synthesis of 1 (Snow, R.; Kelly, T. R.; Adams, J.;…”
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11
Chemical and Enzymatic Resolution of (R,S)-N-(tert-Butoxycarbonyl)-3-hydroxymethylpiperidine
Published in Organic process research & development (01-07-2001)“…(S)-N-(tert-Butoxycarbonyl)-3-hydroxymethylpiperidine 1 was made from (R,S)-3-hydroxymethylpiperidine 2 via fractional crystallization of the corresponding…”
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12
Oxidative N-dearylation of 2-azetidinones. p-Anisidine as a source of azetidinone nitrogen
Published in Journal of organic chemistry (01-07-1982)Get full text
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13
Cupric bromide mediated oxidation of 4-carboxyoxazolines to the corresponding oxazoles
Published in Journal of organic chemistry (01-07-1993)Get full text
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14
One-Carbon Chain Extension of Esters to α-Chloroketones: A Safer Route without Diazomethane
Published in Journal of organic chemistry (05-03-2004)“…The reaction of a variety of methyl esters with dimethylsulfoxonium methylide at 0−25 °C affords the chain-extended β-keto dimethylsulfoxonium ylides…”
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15
Synthesis of (±)-camptothecin using a [3+2] nitrone cycloaddition to construct the CDE ring moiety
Published in Tetrahedron letters (20-09-2004)“…A novel synthesis to camptothecin is described. A Friedlander condensation of o-aminobenzaldehye with tricylclic ketone affords camptothecin after further…”
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16
Enzymatic synthesis of L-6-hydroxynorleucine
Published in Bioorganic & medicinal chemistry (01-10-1999)“…L-6-Hydroxynorleucine, a key chiral intermediate used for synthesis of a vasopeptidase inhibitor, was prepared in 89% yield and > 99% optical purity by…”
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17
Reaction of electron-deficient N-sulfinylanilines with chiral α-hydroxy acids: a new process for the synthesis of enantiomerically pure α-hydroxy amides
Published in Tetrahedron letters (2000)“…A practical procedure to prepare enantiomerically pure α-hydroxy amides from chiral α-hydroxy acids and electron-deficient anilines via N-sulfinylaniline…”
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18
A Practical Synthesis of the RARγ Agonist, BMS-270394
Published in Organic process research & development (01-09-2002)“…A novel synthesis of 1 (BMS-270394), a nuclear retinoic acid receptor (RARγ) agonist, is reported. The synthesis includes an enantioselective reduction of…”
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19
Synthesis and anti-MRSA Activity of Novel Cephalosporin Derivatives
Published in Tetrahedron (28-07-2000)“…Cephalosporin derivatives containing a unique combination of lipophilic C-7 sidechains and polar C-3 thiopyridinium groups were synthesized and found to…”
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A Practical Synthesis of an Anti-Methicillin Resistant Staphylococcus aureus Cephalosporin BMS-247243
Published in Organic process research & development (01-11-2000)“…A practical synthesis of the anti-methicillin resistant Staphylococcus aureus cephem…”
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