Search Results - "Kronenberg‐Versteeg, Deborah"

Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis by Sinner, Pia, Peckert-Maier, Katrin, Mohammadian, Hashem, Kuhnt, Christine, Draßner, Christina, Panagiotakopoulou, Vasiliki, Rauber, Simon, Linnerbauer, Mathias, Haimon, Zhana, Royzman, Dmytro, Kronenberg-Versteeg, Deborah, Ramming, Andreas, Steinkasserer, Alexander, Wild, Andreas B.

“…Microglial activation during neuroinflammation is crucial for coordinating the immune response against neuronal tissue, and the initial response of microglia…”
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Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures by Barth, Melanie, Bacioglu, Mehtap, Schwarz, Niklas, Novotny, Renata, Brandes, Janine, Welzer, Marc, Mazzitelli, Sonia, Häsler, Lisa M, Schweighauser, Manuel, Wuttke, Thomas V, Kronenberg-Versteeg, Deborah, Fog, Karina, Ambjørn, Malene, Alik, Ania, Melki, Ronald, Kahle, Philipp J, Shimshek, Derya R, Koch, Henner, Jucker, Mathias, Tanriöver, Gaye

“…Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the…”
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Monocyte Function in Parkinson's Disease and the Impact of Autologous Serum on Phagocytosis by Wijeyekoon, Ruwani S, Kronenberg-Versteeg, Deborah, Scott, Kirsten M, Hayat, Shaista, Jones, Joanne L, Clatworthy, Menna R, Floto, R Andres, Barker, Roger A, Williams-Gray, Caroline H

“…Increasing evidence implicates involvement of the innate immune system in the initiation and progression of Parkinson's disease (PD). Monocytes and…”
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A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes by Menden, Kevin, Francescatto, Margherita, Nyima, Tenzin, Blauwendraat, Cornelis, Dhingra, Ashutosh, Castillo-Lizardo, Melissa, Fernandes, Noémia, Kaurani, Lalit, Kronenberg-Versteeg, Deborah, Atasu, Burcu, Sadikoglou, Eldem, Borroni, Barbara, Rodriguez-Nieto, Salvador, Simon-Sanchez, Javier, Fischer, Andre, Craig, David Wesley, Neumann, Manuela, Bonn, Stefan, Rizzu, Patrizia, Heutink, Peter

“…Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on…”
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Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions by Tanriöver, Gaye, Bacioglu, Mehtap, Schweighauser, Manuel, Mahler, Jasmin, Wegenast-Braun, Bettina M., Skodras, Angelos, Obermüller, Ulrike, Barth, Melanie, Kronenberg-Versteeg, Deborah, Nilsson, K. Peter R., Shimshek, Derya R., Kahle, Philipp J., Eisele, Yvonne S., Jucker, Mathias

“…Abstract Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein…”
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Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age by Spitzer, Sonia Olivia, Sitnikov, Sergey, Kamen, Yasmine, Evans, Kimberley Anne, Kronenberg-Versteeg, Deborah, Dietmann, Sabine, de Faria, Omar, Agathou, Sylvia, Káradóttir, Ragnhildur Thóra

“…Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during CNS development, are the main proliferative cells in the…”
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Understanding the protective effect of the PLCG2 P522R variant in human microglia by Frik, Jesica, Robert, Aiko, Koppes, Sascha, Erlebach, Lena, Kronenberg‐Versteeg, Deborah, Giera, Martin, Kant, Rik

“…Background Although recent advances in the field suggest significant involvement of the shared pathway between the proteins ApoE and TREM2 in the pathogenesis…”
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Microglial exosomes: taking messaging to new spheres by Kronenberg-Versteeg, Deborah, Varga, Balazs

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Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes by Arif, Sefina, Leete, Pia, Nguyen, Vy, Marks, Katherine, Nor, Nurhanani Mohamed, Estorninho, Megan, Kronenberg-Versteeg, Deborah, Bingley, Polly J, Todd, John A, Guy, Catherine, Dunger, David B, Powrie, Jake, Willcox, Abby, Foulis, Alan K, Richardson, Sarah J, de Rinaldis, Emanuele, Morgan, Noel G, Lorenc, Anna, Peakman, Mark

“…Studies in type 1 diabetes indicate potential disease heterogeneity, notably in the rate of β-cell loss, responsiveness to immunotherapies, and, in limited…”
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ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function by Murakami, Tetsuro, Qamar, Seema, Lin, Julie Qiaojin, Schierle, Gabriele S. Kaminski, Rees, Eric, Miyashita, Akinori, Costa, Ana R., Dodd, Roger B., Chan, Fiona T.S., Michel, Claire H., Kronenberg-Versteeg, Deborah, Li, Yi, Yang, Seung-Pil, Wakutani, Yosuke, Meadows, William, Ferry, Rodylyn Rose, Dong, Liang, Tartaglia, Gian Gaetano, Favrin, Giorgio, Lin, Wen-Lang, Dickson, Dennis W., Zhen, Mei, Ron, David, Schmitt-Ulms, Gerold, Fraser, Paul E., Shneider, Neil A., Holt, Christine, Vendruscolo, Michele, Kaminski, Clemens F., St George-Hyslop, Peter

“…The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS and FTD remain controversial. We propose a model in which low-complexity (LC)…”
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Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease by Wagner, Jessica, Degenhardt, Karoline, Veit, Marleen, Louros, Nikolaos, Konstantoulea, Katerina, Skodras, Angelos, Wild, Katleen, Liu, Ping, Obermüller, Ulrike, Bansal, Vikas, Dalmia, Anupriya, Häsler, Lisa M., Lambert, Marius, De Vleeschouwer, Matthias, Davies, Hannah A., Madine, Jillian, Kronenberg-Versteeg, Deborah, Feederle, Regina, Del Turco, Domenico, Nilsson, K. Peter R., Lashley, Tammaryn, Deller, Thomas, Gearing, Marla, Walker, Lary C., Heutink, Peter, Rousseau, Frederic, Schymkowitz, Joost, Jucker, Mathias, Neher, Jonas J.

“…Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin) are found in the vasculature of almost all humans over 50 years of…”
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Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson’s disease by Wijeyekoon, Ruwani S., Kronenberg-Versteeg, Deborah, Scott, Kirsten M., Hayat, Shaista, Kuan, Wei-Li, Evans, Jonathan R., Breen, David P., Cummins, Gemma, Jones, Joanne L., Clatworthy, Menna R., Floto, R. Andres, Barker, Roger A., Williams-Gray, Caroline H.

“…•Disease relevant innate immune monocyte markers are altered in Parkinson’s disease.•The monocyte marker changes are accompanied by elevated serum bacterial…”
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β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure by Skowera, Ania, Ladell, Kristin, McLaren, James E, Dolton, Garry, Matthews, Katherine K, Gostick, Emma, Kronenberg-Versteeg, Deborah, Eichmann, Martin, Knight, Robin R, Heck, Susanne, Powrie, Jake, Bingley, Polly J, Dayan, Colin M, Miles, John J, Sewell, Andrew K, Price, David A, Peakman, Mark

“…Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that leads to type 1 diabetes, yet the key features of this…”
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Multi‐omic profiling of isogenic ApoE3/3 and ApoE4/4 iPSC‐derived astrocytes uncovers altered lipid metabolism and mitochondrial function of ApoE4 astrocytes by Koppes, Sascha, Feringa, Femke M, Robert, Aiko, Kruijff, Iris Daphne, Olivier‐Jimenez, Damien, Erlebach, Lena, Thompson, Leslie M., Kronenberg‐Versteeg, Deborah, Ori, Alessandro, Mohammed, Yassene, Giera, Martin, van der Kant, Rik

“…Background As the main genetic risk factor for AD, glial ApoE4 has been implicated in a number of early disease relevant processes, such as lipid…”
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Multiomics of iPSC‐derived ApoE3‐ and ApoE4 astrocytes and microglia uncovers cell type specific dysregulation of immunometabolism by van der Kant, Rik, Blomberg, Niek, Erlebach, Lena, Feringa, Femke M, Heijneman, Jorin, Koppes, Sascha, Kruijff, Iris Daphne, McQuade, Amanda, Miramontes, Ricardo, Olivier‐Jimenez, Damien, Robert, Aiko, Thompson, Leslie M., Ori, Alessandro, Kronenberg‐Versteeg, Deborah, Mohammed, Yassene, Kampmann, Martin, Giera, Martin

“…Background ApoE4 is the major genetic risk factor for Alzheimer’s disease and the main lipid transporter in brain. How ApoE4 drives AD pathogenesis, and how…”
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New in vitro tools to investigate the role of microglia in neurodegeneration by Erlebach, Lena, Welzer, Marc, Bühler, Anika, Miely, Daniela, Schwarz, Niklas, Panagiotakopoulou, Vasiliki, Haesler, Lisa M., Lambert, Marius, Obermüller, Ulrike, Beschorner, Natalie, Koch, Henner, Neher, Jonas J., Wuttke, Thomas, Hedrich‐Klimosch, Ulrike, Jucker, Mathias, Kronenberg‐Versteeg, Deborah

“…Background Human induced pluripotent stem cells (iPSCs) have transpired as an attractive tool to investigate neurological diseases. And while immune cells, and…”
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Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes by Kronenberg-Versteeg, Deborah, Eichmann, Martin, Russell, Mark A, de Ru, Arnoud, Hehn, Beate, Yusuf, Norkhairin, van Veelen, Peter A, Richardson, Sarah J, Morgan, Noel G, Lemberg, Marius K, Peakman, Mark

“…The signal peptide region of preproinsulin (PPI) contains epitopes targeted by human leucocyte antigen-A (HLA-A)-restricted (HLA-A0201, A2402) cytotoxic…”
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HLA A24:02-restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes by Dolton, Garry, Bulek, Anna, Wall, Aaron, Thomas, Hannah, Hopkins, Jade R, Rius, Cristina, Galloway, Sarah Ae, Whalley, Thomas, Tan, Li Rong, Morin, Théo, Omidvar, Nader, Fuller, Anna, Topley, Katie, Hasan, Md Samiul, Jain, Shikha, D'Souza, Nirupa, Hodges-Hoyland, Thomas, Spiller, Owen B, Kronenberg-Versteeg, Deborah, Szomolay, Barbara, van den Berg, Hugo A, Jones, Lucy C, Peakman, Mark, Cole, David K, Rizkallah, Pierre J, Sewell, Andrew K

“…CD8+ T cells destroy insulin-producing pancreatic β cells in type 1 diabetes through HLA class I-restricted presentation of self-antigens. Combinatorial…”
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Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice by Kaurani, Lalit, Islam, Md Rezaul, Heilbronner, Urs, Krüger, Dennis M, Zhou, Jiayin, Methi, Aditi, Strauss, Judith, Pradhan, Ranjit, Schröder, Sophie, Burkhardt, Susanne, Schuetz, Anna-Lena, Pena, Tonatiuh, Erlebach, Lena, Bühler, Anika, Budde, Monika, Senner, Fanny, Kohshour, Mojtaba Oraki, Schulte, Eva C, Schmauß, Max, Reininghaus, Eva Z, Juckel, Georg, Kronenberg-Versteeg, Deborah, Delalle, Ivana, Odoardi, Francesca, Flügel, Alexander, Schulze, Thomas G, Falkai, Peter, Sananbenesi, Farahnaz, Fischer, Andre

“…Current approaches to the treatment of schizophrenia have mainly focused on the protein-coding part of the genome; in this context, the roles of microRNAs have…”
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A novel approach to tracking antigen-experienced CD4 T cells into functional compartments via tandem deep and shallow TCR clonotyping by Estorninho, Megan, Gibson, Vivienne B, Kronenberg-Versteeg, Deborah, Liu, Yuk-Fun, Ni, Chester, Cerosaletti, Karen, Peakman, Mark

“…Extensive diversity in the human repertoire of TCRs for Ag is both a cornerstone of effective adaptive immunity that enables host protection against a…”
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