Search Results - "Kronauge, J F"

Uptake and retention of hexakis (2-methoxyisobutyl isonitrile) technetium(I) in cultured chick myocardial cells : mitochondrial and plasma membrane potential dependence by PIWNICA-WORMS, D, KRONAUGE, J. F, CHIU, M. L

“…The fundamental myocellular uptake and retention mechanisms of hexakis (2-methoxyisobutyl isonitrile) technetium(I) (Tc-MIBI), a technetium-99m-based…”
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Effect of Mitochondrial and Plasma Membrane Potentials on Accumulation of Hexakis (2-Methoxyisobutylisonitrile)Technetium(I) in Cultured Mouse Fibroblasts by Chiu, Mary L, Kronauge, James F, Piwnica-Worms, David

“…Hexakis(2-methoxyisobutylisonitrile) technetium(I) (Tc-MIBI) is representative of a class of 99mTc-based lipophilic cationic myocardial perfusion imaging…”
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Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex by PIWNICA-WORMS, D, CHIU, M. L, BUDDING, M, KRONAUGE, J. F, KRAMER, R. A, CROOP, J. M

“…The multidrug-resistant P-glycoprotein (Pgp), a M(r) 170,000 plasma membrane protein encoded by the mammalian multidrug resistance gene (MDR1), appears to…”
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Subcellular Distribution and Analysis of Technetium-99m-MIBI in Isolated Perfused Rat Hearts by Carvalho, Paulo A, Chiu, Mary L, Kronauge, James F, Kawamura, Mieko, Jones, Alun G, Holman, B. Leonard, Piwnica-Worms, David

“…To address the apparent discrepancy between cultured cells and whole heart preparations, Langendorff-perfused rat hearts loaded with hexakis (2-methoxyisobutyl…”
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Expression of Recombinant Human Multidrug Resistance P-Glycoprotein in Insect Cells Confers Decreased Accumulation of Technetium-99m-Sestamibi by Rao, Vallabhaneni V, Chiu, Mary L, Kronauge, James F, Piwnica-Worms, David

“…The multidrug-resistant P-glycoprotein is a M(r) 170,000 plasma membrane protein encoded by the mammalian multidrug resistance gene (MDR) which appears to…”
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Characterization of P-glycoprotein transport and inhibition in vivo by BARBARICS, E, KRONAUGE, J. F, COHEN, D, DAVISON, A, JONES, A. G, CROOP, J. M

“…The P-glycoprotein is an energy-dependent efflux pump capable of decreasing the intracellular concentration of a broad range of chemotherapeutic agents…”
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Effect of Metabolic Inhibition on Technetium 99m-MIBI Kinetics in Cultured Chick Myocardial Cells by Piwnica-Worms, David, Kronauge, James F, Delmon, Laurence, Holman, B. Leonard, Marsh, James D, Jones, Alun G

“…Cellular uptake characteristics of hexakis(methoxyisobutylisonitrile)technetium(I) ([99mTc]MIBI), a myocardial perfusion imaging agent, were evaluated in…”
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Novel Hexakis(areneisonitrile)technetium(I) Complexes as Radioligands Targeted to the Multidrug Resistance P-Glycoprotein by Herman, Lee W, Sharma, Vijay, Kronauge, James F, Barbarics, Eva, Herman, Lisa A, Piwnica-Worms, David

“…Transport substrates and modulators of the human multidrug resistance (MDR1) P-glycoprotein (Pgp) are generally lipophilic cationic compounds, many with…”
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Enhancement by Tetraphenylborate of Technetium-99m-MIBI Uptake Kinetics and Accumulation in Cultured Chick Myocardial Cells by Piwnica-Worms, David, Kronauge, James F, Chiu, Mary L

“…Myocellular uptake and retention of technetium-99m-hexakis (2-methoxyisobutylisonitrile) (Tc-MIBI), a lipophilic cationic myocardial perfusion and viability…”
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Uptake of cationic technetium complexes in cultured human carcinoma cells and human xenografts by Barbarics, Eva, Kronauge, James F., Davison, Alan, Jones, Alun G.

“…We evaluated lipophilicity, in vitro cell accumulation, and biodistribution of a series of 99mTc-ether isonitrile complexes to determine whether increased…”
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A Novel Areneisonitrile Tc Complex Inhibits the Transport Activity of MDR P-Glycoprotein by Rao, Vallabhaneni V, Herman, Lee W, Kronauge, James F, Piwnica-Worms, David

“…P-glycoprotein (Pgp), the product of the multidrug resistance ( MDR1) gene, has been an important cancer target for development of MDR modulators that act to…”
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Effect of histamine on haemorrhagic mucosal lesions is related to vascular permeability in rats: studies with histamine, H1-, H2- and H3-agonists and bradykinin by Palitzsch, K D, Morales, R E, Kronauge, J F, Bynum, T E, Szabo, S

“…To test the hypothesis that an early increase in vascular permeability is correlated with later gastric mucosal protection in the rat. Histamine, its agonists…”
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Divergent kinetics of 201Tl and 99mTc-SESTAMIBI in cultured chick ventricular myocytes during ATP depletion by PIWNICA-WORMS, D, CHIU, M. L, KRONAUGE, J. F

“…Thallous chloride (201Tl) and hexakis(2-methoxyisobutyl isonitrile) technetium (I) (99mTc-SESTAMIBI) are myocardial perfusion imaging agents with biological…”
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Detection of adriamycin-induced cardiotoxicity in cultured heart cells with technetium 99m-SESTAMIBI by PIWNICA-WORMS, D, CHIU, M. L, KRONAUGE, J. F

“…Adriamycin, a broad-spectrum cytotoxic agent useful in cancer chemotherapy, is limited by a dose-dependent cardiomyopathy mediated in part by disruption of…”
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Hexakis(Carbomethoxyisopropylisonitrile) Technetium(I), A New Myocardial Perfusion Imaging Agent: Binding Characteristics in Cultured Chick Heart Cells by Piwnica-Worms, David, Kronauge, James F, Holman, B. Leonard, Lister-James, John, Davison, Alan, Jones, Alun G

“…Cellular kinetics and binding characteristics of hexakis(carbomethoxyisopropylisonitrile) technetium(I) (Tc-CPI), a new cationic, highly lipophilic myocardial…”
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Interspecies Variation in Biodistribution of Technetium (2-Carbomethoxy-2-Isocyanopropane)6 by Kronauge, James F, Noska, Michael A, Davison, Alan, Holman, B. Leonard, Jones, Alun G

“…The cationic complex technetium (2-carbomethoxy-2-isocyanopropane)6+ (99mTc-CPI) contains terminal ester groups that were included to provide a pathway for…”
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In vivo metabolism of the technetium isonitrile complex [Tc(2-ethoxy-2-methyl-1-isocyanopropane)6] by Barbarics, E, Kronauge, J F, Costello, C E, Jànoki, G A, Holman, B L, Davison, A, Jones, A G

“…Technetium(2-ethoxy-2-methyl-1-isocyanopropane)6+, [Tc-EIBT] is a complex of technetium(I) structurally similar but slightly more lipophilic than the…”
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Characterization of Multidrug Resistance P-Glycoprotein Transport Function with an Organotechnetium Cation by Piwnica-Worms, David, Rao, Vallabhaneni V, Kronauge, James F, Croop, James M

“…Multidrug resistance (MDR) in mammalian cells and tumors is associated with overexpression of an approximately 170 kDa integral membrane efflux transporter,…”
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Human Pharmacokinetics and Radiopharmacological Studies of the Myocardial Perfusion Agent: Technetium (2-Carbomethoxy-2-Isocyano-Propane)6 by Kronauge, James F, Leon, Alba S, Verdera, E. Silvia, Balter, Henia S, Leon, Elsa T, Mut, Fernando, Oliveira, M. Cecilia, Garcia, Fernando A, Holman, B. Leonard, Davison, Alan, Jones, Alun G

“…The myocardial perfusion agent technetium (2-carbomethoxy-2-isocyano-propane)6+ (99mTc-CPI) is unique from other cationic technetium isonitrile complexes in…”
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Evaluation of Inorganic Adsorbents for the Rubidium-82 Generator: I. Hydrous SnO2 by Neirinckx, R. D, Kronauge, J. F, Gennaro, G. P, Loberg, M. D

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