Search Results - "Kron, Michael A."

Interconversion between two unrelated protein folds in the lymphotactin native state by Tuinstra, Robbyn L, Peterson, Francis C, Kutlesa, Snjezana, Elgin, E. Sonay, Kron, Michael A, Volkman, Brian F

“…Proteins often have multiple functional states, which might not always be accommodated by a single fold. Lymphotactin (Ltn) adopts two distinct structures in…”
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Nematode Asparaginyl-tRNA Synthetase Resolves Intestinal Inflammation in Mice with T-Cell Transfer Colitis by Kron, Michael A, Metwali, Ahmed, Vodanovic-Jankovic, Sanja, Elliott, David

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Adipostatins A–D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites by Rateb, Mostafa E, Yang, Dong, Vodanovic-Jankovic, Sanja, Yu, Zhiguo, Kron, Michael A, Shen, Ben

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Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J by Rateb, Mostafa E, Yu, Zhiguo, Yan, Yijun, Yang, Dong, Huang, Tingting, Vodanovic-Jankovic, Sanja, Kron, Michael A, Shen, Ben

“…We have recently isolated tirandamycin (TAM) B from Streptomyces sp. 17944 as a Brugia malayi AsnRS ( Bm AsnRS) inhibitor that efficiently kills the adult B…”
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Whole Genome Sequence of a Treponema pallidum Strain From a Formalin-Fixed, Paraffin-Embedded Fine Needle Aspirate of a Cervical Lymph Node by Aldrete, Sol, Kroft, Steven H., Romeis, Emily, Lieberman, Nicole A. P., Greninger, Alexander L., Giacani, Lorenzo, Kron, Michael A.

“…A patient with unilateral cervical lymphadenopathy suspicious for malignancy underwent a fine needle aspiration. Histology demonstrated mixed inflammatory…”
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Solution structure of the N-terminal extension domain of a Schistosoma japonicum asparaginyl-tRNA synthetase by Peck, Yoshimi, Pickering, Darren, Mobli, Mehdi, Liddell, Michael J, Wilson, David T, Ruscher, Roland, Ryan, Stephanie, Buitrago, Geraldine, McHugh, Connor, Love, Nicholas C, Pinlac, Theresa, Haertlein, Michael, Kron, Michael A, Loukas, Alex, Daly, Norelle L

“…Several secreted proteins from helminths (parasitic worms) have been shown to have immunomodulatory activities. Asparaginyl-tRNA synthetases are abundantly…”
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Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change by Sukuru, Sai Chetan K, Crepin, Thibaut, Milev, Youli, Marsh, Liesl C, Hill, Jonathan B, Anderson, Regan J, Morris, Jonathan C, Rohatgi, Anjali, O'Mahony, Gavin, Grøtli, Morten, Danel, Franck, Page, Malcolm G P, Härtlein, Michael, Cusack, Stephen, Kron, Michael A, Kuhn, Leslie A

“…SLIDE software, which models the flexibility of protein and ligand side chains while docking, was used to screen several large databases to identify inhibitors…”
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In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi by Wenkert, David, Ramirez, Bernadette, Shen, Yuehai, Kron, Michael A.

“…Geldanamycin (GA) is a benzoquinone-containing ansamycin that inhibits heat shock protein 90. GA derivatives are being evaluated as anti-neoplastic agents, but…”
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Interleukin-8-like activity in a filarial asparaginyl-tRNA synthetase by Kron, Michael A., Wang, Cheng, Vodanovic-Jankovic, Sanja, Zack Howard, O.M., Kuhn, Leslie A.

“…[Display omitted] Brugia malayi AsnRS has IL-8 like activity. ► IL-8-like activity resides in the tRNA binding domain of the filarial AsnRS. ► Structural…”
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Synthesis and Activity of Substituted Anthraquinones against a Human Filarial Parasite, Brugia malayi by DHANANJEYAN, Mugunthu R., MILEV, Youli P., KRON, Michael A., NAIR, Muraleedharan G.

“…Lymphatic filariasis (elephantiasis) is a global public health problem caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. We have…”
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Contrasting Wuchereria bancrofti microfilaria rates in two Mangyan-populated Philippine villages by Ramirez, Bernadette L, Hernandez, Leda, Alberto, Faith F, Collins, Michael, Nfonsam, Valentine, Punsalan, Tricia, Kron, Michael A

“…Lymphatic filariasis caused by infection with Wuchereria bancrofti and Brugia malayi is endemic in 45 of 77 provinces in The Philippines. To prepare the island…”
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Anti-KS: Identification of Autoantibodies to Asparaginyl-Transfer RNA Synthetase Associated with Interstitial Lung Disease by Hirakata, Michito, Suwa, Akira, Nagai, Sonoko, Kron, Michael A, Trieu, Edward P, Mimori, Tsuneyo, Akizuki, Masashi, Targoff, Ira N

“…Autoantibodies to five of the aminoacyl-transfer RNA (tRNA) synthetases have been described, and each is associated with a syndrome of inflammatory myopathy…”
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Using structural analysis to generate parasite‐selective monoclonal antibodies by Kron, Michael A., Cichanowicz, Sam, Hendrick, Angela, Liu, Aizhuo, Leykam, Joseph, Kuhn, Leslie A.

“…Diagnosis of eukaryotic parasitic infection using antibody‐based tests such as ELISAs (enzyme‐linked immunosorbent assays) is often problematic because of the…”
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Synthesis and Activity of Substituted Anthraquinones against a Human Filarial Parasite, Brugia m alayi by Dhananjeyan, Mugunthu R, Milev, Youli P, Kron, Michael A, Nair, Muraleedharan G

“…Lymphatic filariasis (elephantiasis) is a global public health problem caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. We have…”
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Do tissue levels of autoantigenic aminoacyl-tRNA synthetase predict clinical disease? by Kron, Michael A., Petridis, Michael, Haertlein, Michael, Libranda-Ramirez, Bernadette, Scaffidi, Linda E.

“…The etiologies of most autoimmune diseases are not completely understood. Aminoacyl-tRNA synthetases (AARS) are a family of heterogenous enzymes responsible…”
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Whole genome sequence of a Treponema pallidum strain from a formalin-fixed paraffin-embedded fine needle aspirate of a cervical lymph node by Aldrete, Sol, Kroft, Steven H., Romeis, Emily, Lieberman, Nicole A.P., Greninger, Alexander L., Giacani, Lorenzo, Kron, Michael A.

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Crystallization and preliminary X-ray diffraction analysis of human cytosolic seryl-tRNA synthetase by Artero, Jean-Baptiste, Teixeira, Susana C. M., Mitchell, Edward P., Kron, Michael A., Forsyth, V. Trevor, Haertlein, Michael

“…Human cytosolic seryl‐tRNA synthetase (hsSerRS) is responsible for the covalent attachment of serine to its cognate tRNASer. Significant differences between…”
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Molecular Microbiology in Clinical Practice: Current and Future Applications by Tracy Biney-Assan, Michael Kron

“…Technological advances have yielded new molecular biology-based methods for the diagnosis of infectious diseases.  The newest and most powerful molecular…”
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Hyperimmunoglobulinemia E in the absence of atopy and filarial infection: the Huaorani of Ecuador by Kron, M A, Ammunariz, M, Pandey, J, Guzman, J R

“…Hyperimmunoglobulinemia E (HIGE) is associated with various conditions such as atopy, dermatitis, hypersensitivity reactions, and certain parasitic infections…”
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Incorporation of Nurse Practitioners and Physician Assistants into patient care teams - Focus on infectious Diseases by Jennifer Bingen, Rebecca Krueger, Annie Lakatos, Julie Raaum, Michael Kron

“…There is a global shortage of health care providers needed to address all levels of primary and specialty care.  The recent COVID-19 pandemic also highlights…”
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