Search Results - "Kroll, Robert A."

Magnetic resonance imaging features and outcome for solitary central nervous system coccidioides granulomas in 11 dogs and cats by Bentley, R. Timothy, Heng, Hock Gan, Thompson, Craig, Lee, Chun-Sheng, Kroll, Robert A., Roy, Michael E., Marini, Lauren, Heo, Jin, Wigle, William L.

“…Little published information is available to guide therapy for canine and feline patients with Coccidioides infections involving the central nervous system…”
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Delayed Administration of Sodium Thiosulfate in Animal Models Reduces Platinum Ototoxicity without Reduction of Antitumor Activity by MULDOON, L. L, PAGEL, M. A, KROLL, R. A, BRUMMETT, R. E, DOOLITTLE, N. D, ZUHOWSKI, E. G, EGORIN, M. J, NEUWELT, E. A

“…Platinum-based chemotherapeutic agents, such as carboplatin and cisplatin, are effective against many human tumors, but their use may be limited by a high…”
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First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using sodium thiosulfate by Neuwelt, E A, Brummett, R E, Doolittle, N D, Muldoon, L L, Kroll, R A, Pagel, M A, Dojan, R, Church, V, Remsen, L G, Bubalo, J S

“…Sodium thiosulfate (STS) provides protection against carboplatin-induced ototoxicity in an animal model. The purpose of this study was to determine the STS…”
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A Physiological Barrier Distal to the Anatomic Blood-Brain Barrier in a Model of Transvascular Delivery by Muldoon, Leslie L, Pagel, Michael A, Kroll, Robert A, Roman-Goldstein, Simon, Jones, Russell S, Neuwelt, Edward A

“…Osmotic disruption of the blood-brain barrier (BBB) provides a method for transvascular delivery of therapeutic agents to the brain. The apparent global…”
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Delivery of Herpesvirus and Adenovirus to Nude Rat Intracerebral Tumors After Osmotic Blood-Brain Barrier Disruption by Nilaver, Gajanan, Muldoon, Leslie L., Kroll, Robert A., Pagel, Michael A., Breakefield, Xandra O., Davidson, Beverly L., Neuwelt, Edward A.

“…The delivery of viral vectors to the brain for treatment of intracerebral tumors is most commonly accomplished by stereotaxic inoculation directly into the…”
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In vitro and animal studies of sodium thiosulfate as a potential chemoprotectant against carboplatin-induced ototoxicity by Neuwelt, E A, Brummett, R E, Remsen, L G, Kroll, R A, Pagel, M A, McCormick, C I, Guitjens, S, Muldoon, L L

“…When carboplatin (cis-diammine-1,1-cyclobutane-dicarboxylato-platinum) delivery to brain tumors is optimized with osmotic blood-brain barrier disruption…”
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Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means by Kroll, R A, Neuwelt, E A

“…This article reviews historical aspects of the blood-brain barrier (BBB) and recent advances in mechanisms to deliver therapeutic agents across the BBB for the…”
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Improving drug delivery to intracerebral tumor and surrounding brain in a rodent model: a comparison of osmotic versus bradykinin modification of the blood-brain and/or blood-tumor barriers by Kroll, R A, Pagel, M A, Muldoon, L L, Roman-Goldstein, S, Fiamengo, S A, Neuwelt, E A

“…To compare transient blood-brain barrier disruption (BBBD) by hypertonic mannitol with pharmacological modification of the blood-tumor barrier by the…”
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Increasing volume of distribution to the brain with interstitial infusion: dose, rather than convection, might be the most important factor by Kroll, R A, Pagel, M A, Muldoon, L L, Roman-Goldstein, S, Neuwelt, E A

“…The volume of distribution in tissue (Vt) that can be achieved by direct interstitial infusion of therapeutic agents into brain is limited. The maintenance of…”
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MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis by Remsen, LG, McCormick, CI, Roman-Goldstein, S, Nilaver, G, Weissleder, R, Bogdanov, A, Hellstrom, I, Kroll, RA, Neuwelt, EA

“…To determine if tumor-specific monoclonal antibodies conjugated to superparamagnetic monocrystalline iron oxide nanoparticles can be used to yield specific…”
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COMMENTS by Neuwelt, Edward A., Kroll, Robert A.

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Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain by Muldoon, LL, Nilaver, G, Kroll, RA, Pagel, MA, Breakefield, XO, Chiocca, EA, Davidson, BL, Weissleder, R, Neuwelt, EA

“…Delivery of adenovirus, herpes simplex virus (HSV), and paramagnetic monocrystalline iron oxide nanoparticles (MION) to rat brain (n = 64) was assessed after…”
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Delivery of Virus-sized Iron Oxide Particles to Rodent CNS Neurons by Neuwelt, Edward A., Weissleder, Ralph, Nilaver, Gajanan, Kroll, Robert A., Roman-Goldstein, Simon, Szumowski, Jerzy, Pagel, Michael A., Jones, Russell S., Remsen, Laura G., McCormick, Christopher I., Shannon, Eva M., Muldoon, Leslie L.

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Differential permeability of a human brain tumor xenograft in the nude rat: impact of tumor size and method of administration on optimizing delivery of biologically diverse agents by NEUWELT, E. A, BARNETT, P. A, MCCORMICK, C. I, REMSEN, L. G, KROLL, R. A, SEXTON, G

“…To assess how to maximize drug delivery to intracerebral tumors and surrounding brain, this study examined the effects of route and method of administration…”
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Myelinolysis after correction of hyponatremia in two dogs by O'Brien, D.P, Kroll, R.A, Johnson, G.C, Covet, S.J, Nelson, M.J

“…Two dogs developed delayed neurological deterioration after rapid correction of severe hyponatremia. Sequential magnetic resonance imaging showed the…”
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Dysautonomia in dogs: a retrospective study by Longshore, R.C. (University of Missouri-Columbia, Columbia, MO.), O'Brien, D.P, Johnson, G.C, Grooters, A.M, Kroll, R.A

“…Dysautonomia was diagnosed in 11 young (median age, 14–months), predominantly medium‐ to large‐breed dogs from 1988 to 1995. Clinical signs caused by autonomic…”
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Nimodipine for treatment of idiopathic epilepsy in dogs by O'Brien, D P, Simpson, S T, Longshore, R C, Kroll, R A, Goetze, L

“…To evaluate efficacy and safety of the calcium channel antagonist nimodipine in dogs with idiopathic epilepsy. Prospective clinical trial. 10 dogs with…”
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Medical dissolution of feline struvite urocystoliths by Osborne, C A, Lulich, J P, Kruger, J M, Polzin, D J, Johnston, G R, Kroll, R A

“…The efficacy of a diet designed to facilitate dissolution of feline magnesium ammonium phosphate (struvite) uroliths was evaluated in 30 cases of urolithiasis,…”
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Delivery of virus-sized iron oxide particles to rodent CNS neurons by Neuwelt, E A, Weissleder, R, Nilaver, G, Kroll, R A, Roman-Goldstein, S, Szumowski, J, Pagel, M A, Jones, R S, Remsen, L G, McCormick, C I

“…Delivery of viral particles to the brain is limited by the volume of distribution that can be obtained. Additionally, there is currently no way to…”
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Thoracolumbar vertebral osteochondroma in a young dog by Santen, D R, Payne, J T, Pace, L W, Kroll, R A, Johnson, G C

“…Osteosarcoma was diagnosed in a 7-month-old female German Shepherd Dog with hind limb paresis. Radiography revealed a circumscribed calcified mass in the…”
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