Search Results - "Krolewski, John"

Opportunities and challenges in combination gene cancer therapy by Nastiuk, Kent L., Krolewski, John J.

“…Treatment for solid tumor malignancies, which constitute the majority of human cancers, is still dominated by surgery and radiotherapies. This is especially…”
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Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma by Li, Fengzhi, Aljahdali, Ieman A M, Zhang, Renyuan, Nastiuk, Kent L, Krolewski, John J, Ling, Xiang

“…The incidence of renal cell carcinoma (RCC) is increasing worldwide with an approximate 20% mortality rate. The challenge in RCC is the therapy-resistance…”
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MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes by Liu, Can, Liu, Ruifang, Zhang, Dingxiao, Deng, Qu, Liu, Bigang, Chao, Hsueh-Ping, Rycaj, Kiera, Takata, Yoko, Lin, Kevin, Lu, Yue, Zhong, Yi, Krolewski, John, Shen, Jianjun, Tang, Dean G.

“…MicroRNAs play important roles in regulating tumour development, progression and metastasis. Here we show that one of the miR-200 family members, miR-141, is…”
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Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase by Lerman, Irina, Garcia-Hernandez, Maria de la Luz, Rangel-Moreno, Javier, Chiriboga, Luis, Pan, Chunliu, Nastiuk, Kent L, Krolewski, John J, Sen, Aritro, Hammes, Stephen R

“…Tissue infiltration and elevated peripheral circulation of granulocytic myeloid-derived cells is associated with poor outcomes in prostate cancer and other…”
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Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study by Eng, Kevin H, Szender, J Brian, Etter, John Lewis, Kaur, Jasmine, Poblete, Samantha, Huang, Ruea-Yea, Zhu, Qianqian, Grzesik, Katherine A, Battaglia, Sebastiano, Cannioto, Rikki, Krolewski, John J, Zsiros, Emese, Frederick, Peter J, Lele, Shashikant B, Moysich, Kirsten B, Odunsi, Kunle O

“…Given prior evidence that an affected woman conveys a higher risk of ovarian cancer to her sister than to her mother, we hypothesized that there exists an…”
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TGFβ Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice by Pan, Chunliu, Singh, Shalini, Sahasrabudhe, Deepak M, Chakkalakal, Joe V, Krolewski, John J, Nastiuk, Kent L

“…First line treatment for recurrent and metastatic prostate cancer is androgen deprivation therapy (ADT). Use of ADT has been increasing in frequency and…”
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Validation of Melanoma Immune Profile (MIP), a Prognostic Immune Gene Prediction Score for Stage II-III Melanoma by Gartrell, Robyn D, Marks, Douglas K, Rizk, Emanuelle M, Bogardus, Margaret, Gérard, Camille L, Barker, Luke W, Fu, Yichun, Esancy, Camden L, Li, Gen, Ji, Jiayi, Rui, Shumin, Ernstoff, Marc S, Taback, Bret, Pabla, Sarabjot, Chang, Rui, Lee, Sandra J, Krolewski, John J, Morrison, Carl, Horst, Basil A, Saenger, Yvonne M

“…Biomarkers are needed to stratify patients with stage II-III melanoma for clinical trials of adjuvant therapy because, while immunotherapy is protective, it…”
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Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-β1/Smad/MMP9 signals by Xie, Hongjun, Li, Lei, Zhu, Guodong, Dang, Qiang, Ma, Zhenkun, He, Dalin, Chang, Luke, Song, Wenbing, Chang, Hong-Chiang, Krolewski, John J, Nastiuk, Kent L, Yeh, Shuyuan, Chang, Chawnshang

“…High fat dietary intake may increase the risk of prostate cancer (PCa). Pre-adipocytes, one of the basic components in the tumor microenvironment (TME), are…”
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TNF Signaling Is Required for Castration-Induced Vascular Damage Preceding Prostate Cancer Regression by Krolewski, John J, Singh, Shalini, Sha, Kai, Jaiswal, Neha, Turowski, Steven G, Pan, Chunliu, Rich, Laurie J, Seshadri, Mukund, Nastiuk, Kent L

“…The mainstay treatment for locally advanced, recurrent, or metastatic prostate cancer (PrCa) is androgen deprivation therapy (ADT). ADT causes prostate cancers…”
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Photoacoustic imaging with an acoustic lens detects prostate cancer cells labeled with PSMA-targeting near-infrared dye-conjugates by Dogra, Vikram, Chinni, Bhargava, Singh, Shalini, Schmitthenner, Hans, Rao, Navalgund, Krolewski, John J, Nastiuk, Kent L

“…There is an urgent need for sensitive and specific tools to accurately image early stage, organ-confined human prostate cancers to facilitate active…”
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Loss of MAGEC3 Expression Is Associated with Prognosis in Advanced Ovarian Cancers by Ellegate, Jr, James, Mastri, Michalis, Isenhart, Emily, Krolewski, John J, Chatta, Gurkamal, Kauffman, Eric, Moffitt, Melissa, Eng, Kevin H

“…Rare variants in MAGEC3 are associated with BRCA negative, early-onset ovarian cancers. Given this association, we evaluated the impact of MAGEC3 protein…”
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Loss of PLZF expression in prostate cancer by immunohistochemistry correlates with tumor aggressiveness and metastasis by Xiao, Guang-Qian, Unger, Pamela, Yang, Qi, Kinoshita, Yayoi, Singh, Kyra, McMahon, Loralee, Nastiuk, Kent, Sha, Kai, Krolewski, John, Burstein, David

“…PLZF is a transcription repressor, which plays a critical role in development, spermatogenesis and oncogenesis. Down-regulation of PLZF has been found in…”
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TNF signaling mediates an enzalutamide-induced metastatic phenotype of prostate cancer and microenvironment cell co-cultures by Sha, Kai, Yeh, Shuyuan, Chang, Chawnshang, Nastiuk, Kent L, Krolewski, John J

“…The dramatic responses tumors display to targeted therapies are limited by acquired or pre-existing mechanisms of therapy resistance. We recently discovered…”
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TNF Is Necessary for Castration-Induced Prostate Regression, Whereas TRAIL and FasL Are Dispensable by Davis, Jennifer S, Nastiuk, Kent L, Krolewski, John J

“…TNF is required for prostate regression and increases in a paracrine manner following castration; conversely, TRAIL and Fas are dispensable for this process…”
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Phosphorylation and Specific Ubiquitin Acceptor Sites Are Required for Ubiquitination and Degradation of the IFNAR1 Subunit of Type I Interferon Receptor by Kumar, K G Suresh, Krolewski, John J, Fuchs, Serge Y

“…Ubiquitination, endocytosis, and lysosomal degradation of the IFNAR1 (interferon α receptor 1) subunit of the type I interferon (IFN) receptor is mediated by…”
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Quantitative volumetric imaging of normal, neoplastic and hyperplastic mouse prostate using ultrasound by Singh, Shalini, Pan, Chunliu, Wood, Ronald, Yeh, Chiuan-Ren, Yeh, Shuyuan, Sha, Kai, Krolewski, John J, Nastiuk, Kent L

“…Genetically engineered mouse models are essential to the investigation of the molecular mechanisms underlying human prostate pathology and the effects of…”
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Correction: Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-β1/Smad/MMP9 signals by Xie, Hongjun, Li, Lei, Zhu, Guodong, Dang, Qiang, Ma, Zhenkun, He, Dalin, Chang, Luke, Song, Wenbing, Chang, Hong-Chiang, Krolewski, John J, Nastiuk, Kent L, Yeh, Shuyuan, Chang, Chawnshang

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Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia by Pan, Chunliu, Jaiswal Agrawal, Neha, Zulia, Yanni, Singh, Shalini, Sha, Kai, Mohler, James L, Eng, Kevin H, Chakkalakal, Joe V, Krolewski, John J, Nastiuk, Kent L

“…Most prostate cancers depend on androgens for growth, and therefore, the mainstay treatment for advanced, recurrent, or metastatic prostate cancer is androgen…”
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Cytokine and growth factor receptors in the nucleus: What's up with that? by Krolewski, John J.

“…Signaling via cell surface receptors that are anchored by a single transmembrane domain is a well‐established paradigm. Ligand binding to the extracellular…”
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FLIP-ping out: Death receptor signaling in the prostate by Nastiuk, Kent L., Krolewski, John J.

“…Prostate cancer is a leading cause of cancer related death. The growth of normal prostate epithelial cells is under the tight control of various growth…”
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