Search Results - "Krohne, Christian"

Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease by Gramlich, Michael, Michely, Beate, Krohne, Christian, Heuser, Arnd, Erdmann, Bettina, Klaassen, Sabine, Hudson, Bryan, Magarin, Manuela, Kirchner, Florian, Todiras, Mihail, Granzier, Henk, Labeit, Siegfried, Thierfelder, Ludwig, Gerull, Brenda

“…Abstract Mutations in a variety of myofibrillar genes cause dilated cardiomyopathy (DCM) in humans, usually with dominant inheritance and incomplete…”
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MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance by Moriscot, Anselmo S., Baptista, Igor L., Bogomolovas, Julius, Witt, Christian, Hirner, Stephanie, Granzier, Henk, Labeit, Siegfried

“…MuRF1 is a member of the RBCC (RING, B-box, coiled-coil) superfamily that has been proposed to act as an atrogin during muscle wasting. Here, we show that…”
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Induction of MuRF1 Is Essential for TNF-α-Induced Loss of Muscle Function in Mice by Adams, Volker, Mangner, Norman, Gasch, Alexander, Krohne, Christian, Gielen, Stephan, Hirner, Stephanie, Thierse, Hermann-Josef, Witt, Christian C., Linke, Axel, Schuler, Gerhard, Labeit, Siegfried

“…Humoral circulating inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) can impair skeletal muscle contractility. Furthermore, TNF-α expression…”
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MuRF1-dependent Regulation of Systemic Carbohydrate Metabolism as Revealed from Transgenic Mouse Studies by Hirner, Stephanie, Krohne, Christian, Schuster, Alexander, Hoffmann, Sigrid, Witt, Stephanie, Erber, Ralf, Sticht, Carsten, Gasch, Alexander, Labeit, Siegfried, Labeit, Dittmar

“…Under various pathophysiological muscle-wasting conditions, such as diabetes and starvation, a family of ubiquitin ligases, including muscle-specific…”
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Abstract 1252: A Mouse Model of a Familial Dilated Cardiomyopathy Mutation in Titin Recapitulates the Human Phenotype by Gramlich, Michael, Michely, Beate, Gerull, Brenda, Krohne, Christian, Morano, Ingo, Labeit, Siegfried, Thierfelder, Ludwig

“…Abstract only Dilated cardiomyopathy (DCM) is the most common form of primary myocardial diseases and the third most common cause of heart failure. Familial…”
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