Search Results - "Krogstad, Veronica"
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Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial
Published in Clinical and translational science (01-01-2022)“…It remains uncertain whether pharmacokinetic changes following Roux‐en‐Y gastric bypass (RYGB) can be attributed to surgery‐induced gastrointestinal…”
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Determination of Tacrolimus Concentration and Protein Expression of P-Glycoprotein in Single Human Renal Core Biopsies
Published in Therapeutic drug monitoring (01-06-2018)“…Tacrolimus (TAC) is currently the cornerstone of immunosuppressive protocols for renal transplant recipients. Despite therapeutic whole blood monitoring, TAC…”
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Bacillus thuringiensis CbpA is a collagen binding cell surface protein under c-di-GMP control
Published in Cell surface (Amsterdam) (01-12-2019)“…Cyclic diguanylate (c-di-GMP) signalling affects several cellular processes in Bacillus cereus group bacteria including biofilm formation and motility, and…”
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The influence of bariatric surgery on oral drug bioavailability in patients with obesity: A systematic review
Published in Obesity reviews (01-09-2019)“…Summary Anatomical changes in the gastrointestinal tract and subsequent weight loss may influence drug disposition and thus drug dosing following bariatric…”
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Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes
Published in Molecular pharmaceutics (05-04-2021)“…Human liver microsomes (HLM) and human hepatocytes (HH) are important in vitro systems for studies of intrinsic drug clearance (CLint) in the liver. However,…”
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High Plasma Oxalate Levels Early After Kidney Transplantation Are Associated With Impaired Long-Term Outcomes
Published in Transplant international (2022)“…Elevated levels of oxalate are common in renal failure patients and non-hyperoxaluria disease, and may cause damage after transplantation. We examined outcomes…”
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Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity
Published in British journal of clinical pharmacology (01-09-2022)“…Aim Roux‐en‐Y gastric bypass (RYGB) may influence drug disposition due to surgery‐induced gastrointestinal alterations and/or subsequent weight loss. The…”
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A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity
Published in Drug metabolism and disposition (01-01-2020)“…The liver and small intestine restrict oral bioavailability of drugs and constitute the main sites of pharmacokinetic drug-drug interactions. Hence, detailed…”
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Reply to letter: “What about drug bioavailability in patients who had bariatric surgery and dependent on immunosuppressives?”
Published in Obesity reviews (01-02-2020)Get full text
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Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance
Published in Clinical pharmacokinetics (01-05-2023)“…Introduction Rosuvastatin pharmacokinetics is mainly dependent on the activity of hepatic uptake transporter OATP1B1. In this study, we aimed to investigate…”
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Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range
Published in European journal of clinical pharmacology (01-08-2022)“…Purpose Variability in cytochrome P450 3A4 (CYP3A4) metabolism is mainly caused by non-genetic factors, hence providing a need for accurate phenotype…”
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Determination of Tacrolimus Concentration and Protein Expression of P-glycoprotein in Single Human Renal Core Biopsies
Published in Transplantation (01-07-2018)“…INTRODUCTIONTacrolimus is currently the cornerstone of immunosuppressive protocols for renal transplant recipients. Despite therapeutic whole blood monitoring,…”
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Impact of body weight, low energy diet and gastric bypass on drug bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol for an open, non-randomised, three-armed single centre study (COCKTAIL)
Published in BMJ open (01-05-2018)“…IntroductionRoux-en-Y gastric bypass (GBP) is associated with changes in cardiometabolic risk factors and bioavailability of drugs, but whether these changes…”
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