Search Results - "Kroger, Charles J."

Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response by Clark, Matthew, Kroger, Charles J, Tisch, Roland M

“…Inflammation is typically induced in response to a microbial infection. The release of proinflammatory cytokines enhances the stimulatory capacity of…”
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Thymic Dendritic Cell Subsets Display Distinct Efficiencies and Mechanisms of Intercellular MHC Transfer by Kroger, Charles J, Spidale, Nicholas A, Wang, Bo, Tisch, Roland

“…Thymic dendritic cells (DC) delete self-antigen-specific thymocytes, and drive development of Foxp3-expressing immunoregulatory T cells. Unlike medullary…”
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Evolving Antibody Therapies for the Treatment of Type 1 Diabetes by Ke, Qi, Kroger, Charles J, Clark, Matthew, Tisch, Roland M

“…Type 1 diabetes (T1D) is widely considered to be a T cell driven autoimmune disease resulting in reduced insulin production due to dysfunction/destruction of…”
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The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes by Clark, Matthew, Kroger, Charles J, Ke, Qi, Tisch, Roland M

“…T cell receptor (TCR) signaling influences multiple aspects of CD4 and CD8 T cell immunobiology including thymic development, peripheral homeostasis, effector…”
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Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes by Kroger, Charles J, Clark, Matthew, Ke, Qi, Tisch, Roland M

“…Type 1 diabetes (T1D) is an autoimmune disease that is generally considered to be T cell-driven. Accordingly, most strategies of immunotherapy for T1D…”
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Coreceptor therapy has distinct short- and long-term tolerogenic effects intrinsic to autoreactive effector T cells by Clark, Matthew, Kroger, Charles J, Ke, Qi, Zhang, Rui, Statum, Karen, Milner, J Justin, Martin, Aaron, Wang, Bo, Tisch, Roland

“…Immunotherapies are needed in the clinic that effectively suppress β cell autoimmunity and reestablish long-term self-tolerance in type 1 diabetes. We…”
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Temporal increase in thymocyte negative selection parallels enhanced thymic SIRPα+ DC function by Kroger, Charles J., Wang, Bo, Tisch, Roland

“…Dysregulation of negative selection contributes to T‐cell‐mediated autoimmunity, such as type 1 diabetes. The events regulating thymic negative selection,…”
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MerTK Regulates Thymic Selection of Autoreactive T Cells by Wallet, Mark A., Flores, Rafael R., Wang, Yaming, Yi, Zuoan, Kroger, Charles J., Mathews, Clayton E., Earp, H. Shelton, Matsushima, Glenn, Wang, Bo, Tisch, Roland, McDevitt, Hugh O.

“…T cell-mediated autoimmune diseases such as type 1 diabetes (T1D) are believed to be the result in part of inefficient negative selection of self-specific…”
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Prevention of Type 1 Diabetes with Acetalated Dextran Microparticles Containing Rapamycin and Pancreatic Peptide P31 by Chen, Naihan, Kroger, Charles J., Tisch, Roland M., Bachelder, Eric M., Ainslie, Kristy M.

“…Type 1 diabetes (T1D) is a common autoimmune disease with no cure. T1D subjects are dependent on daily exogenous insulin administration, due to the loss of…”
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Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner by He, Qiuming, Morillon, 2nd, Y Maurice, Spidale, Nicholas A, Kroger, Charles J, Liu, Bo, Sartor, R Balfour, Wang, Bo, Tisch, Roland

“…Inefficient thymic negative selection of self-specific T cells is associated with several autoimmune diseases, including type 1 diabetes. The factors that…”
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Cutting Edge: CD8+ T Cell Clones Possess the Potential to Differentiate into both High- and Low-Avidity Effector Cells by Kroger, Charles J, Alexander-Miller, Martha A

“…The property of functional avidity is recognized to be of critical importance in determining pathogen clearance. An unresolved question with regard to this…”
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Cutting Edge: Dendritic Cells Prime a High Avidity CTL Response Independent of the Level of Presented Antigen by Kroger, Charles J, Amoah, Samuel, Alexander-Miller, Martha A

“…CTL that possess a high functional avidity are known to be optimal for the clearance of pathogens in vivo. We have shown that the amount of peptide encountered…”
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Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter by Kroger, Charles J, Alexander-Miller, Martha A

“…The generation of an optimal CD8⁺ cytotoxic T lymphocyte (CTL) response is critical for the clearance of many intracellular pathogens. Previous studies suggest…”
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Dysregulation of Thymic Clonal Deletion and the Escape of Autoreactive T Cells by Kroger, Charles J, Flores, Rafael R, Morillon, Maurice, Wang, Bo, Tisch, Roland

“…Events ongoing in the thymus are critical for deleting developing thymocytes specific for tissue antigens, and establishing self-tolerance within the T cell…”
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Temporal increase in thymocyte negative selection parallels enhanced thymic SIRP alpha super(+) DC function by Kroger, Charles J, Wang, Bo, Tisch, Roland

“…Dysregulation of negative selection contributes to T-cell-mediated autoimmunity, such as type 1 diabetes. The events regulating thymic negative selection,…”
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Temporal increase in thymocyte negative selection parallels enhanced thymic SIRP[alpha]+ DC function by Kroger, Charles J, Wang, Bo, Tisch, Roland

“…Dysregulation of negative selection contributes to T-cell-mediated autoimmunity, such as type 1 diabetes. The events regulating thymic negative selection,…”
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High avidity CD8 + T cells generated from CD28-deficient or wildtype mice exhibit a differential dependence on lipid raft integrity for activation by Cawthon, Andrew G., Kroger, Charles J., Alexander-Miller, Martha A.

“…CD28 has been shown to play an important role in T cell activation. Among the downstream events associated with CD28 engagement is the reorganization of the…”
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Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner1 by He, Qiuming, Morillon, Y. Maurice, Spidale, Nicholas A., Kroger, Charles J., Liu, Bo, Sartor, R. Balfour, Wang, Bo, Tisch, Roland

“…Inefficient thymic negative selection of self-specific T cells is associated with several autoimmune diseases, including type 1 diabetes (T1D). The factors…”
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Cutting Edge: CD8 super(+) T Cell Clones Possess the Potential to Differentiate into both High- and Low-Avidity Effector Cells by Kroger, Charles J, Alexander-Miller, Martha A

“…The property of functional avidity is recognized to be of critical importance in determining pathogen clearance. An unresolved question with regard to this…”
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CD8+ T Cells Possess the Potential to Differentiate into Both a High or Low Avidity Effector Cell (87.7) by Kroger, Charles J., Alexander-Miller, Martha A.

“…During an immune response, CTL clones are present that exhibit a wide spectrum of peptide sensitivities. While the property of functional avidity has been well…”
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