Search Results - "Kroger, Benjamin"

CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors by Walens, Andrea, DiMarco, Ashley V, Lupo, Ryan, Kroger, Benjamin R, Damrauer, Jeffrey S, Alvarez, James V

“…Over half of breast-cancer-related deaths are due to recurrence 5 or more years after initial diagnosis and treatment. This latency suggests that a population…”
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Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade by Gu, Shengqing Stan, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael P, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok K, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason L, Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon J, Rodig, Scott, Long, Henry W, Gewurz, Benjamin E, Hodi, F Stephen, Brown, Myles, Liu, X Shirley

“…Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined…”
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Clonal tracing reveals diverse patterns of response to immune checkpoint blockade by Gu, Shengqing Stan, Wang, Xiaoqing, Hu, Xihao, Jiang, Peng, Li, Ziyi, Traugh, Nicole, Bu, Xia, Tang, Qin, Wang, Chenfei, Zeng, Zexian, Fu, Jingxin, Meyer, Cliff, Zhang, Yi, Cejas, Paloma, Lim, Klothilda, Wang, Jin, Zhang, Wubing, Tokheim, Collin, Sahu, Avinash Das, Xing, Xiaofang, Kroger, Benjamin, Ouyang, Zhangyi, Long, Henry, Freeman, Gordon J, Brown, Myles, Liu, X Shirley

“…Immune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but only a minority of cancer patients respond. Multiple…”
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Liquid biopsy‐based circulating tumour (ct)DNA analysis of a spectrum of myeloid and lymphoid malignancies yields clinically actionable results by Mata, Douglas A, Lee, Jessica K, Shanmugam, Vignesh, Marcus, Chelsea B, Schrock, Alexa B, Williams, Erik A, Ritterhouse, Lauren L, Hickman, Richard A, Janovitz, Tyler, Patel, Nimesh R, Kroger, Benjamin R, Ross, Jeffrey S, Mirza, Kamran M, Oxnard, Geoffrey R, Vergilio, Jo‐Anne, Elvin, Julia A, Benhamida, Jamal K, Decker, Brennan, Xu, Mina L

“…Aims Liquid biopsy (LBx)‐based next‐generation sequencing (NGS) of circulating tumour DNA (ctDNA) can facilitate molecular profiling of haematopoietic…”
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Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition by Damrauer, Jeffrey S, Phelps, Stephanie N, Amuchastegui, Katie, Lupo, Ryan, Mabe, Nathaniel W, Walens, Andrea, Kroger, Benjamin R, Alvarez, James V

“…Tumor recurrence is a leading cause of death and is thought to arise from a population of residual cells that survive treatment. These residual cancer cells…”
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700 Increasing MHC-I expression to potentiate immune checkpoint blockade therapy by Gu, Shengqing, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason, Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon, Rodig, Scott, Long, Henry, Gewurz, Benjamin, Stephen Hodi, F., Brown, Myles, Shirley Liu, X

“…BackgroundCancer immunotherapy, especially immune checkpoint blockade (ICB) therapy, is leading to a paradigm shift in cancer treatment, as a small percentage…”
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Defining Clonal Hematopoiesis in Childhood Cancer Survivors[a Prospective, Single Center Study] by Greer, Chelsee, Kroger, Benjamin, Chung, Stephen S., Dickerson, Kathryn

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High Throughput Multi‐omic Characterization of Clonal Hematopoietic Stem Cells During Progression of Myeloid Malignancies by Son, Albert J., Kroger, Benjamin, Huang, Yi, Chung, Stephen

“…Hematopoietic stem cells (HSCs) are responsible for giving rise to all other lineages of blood cells in the body. Over time, mutations in HSCs can promote the…”
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Clonal Hematopoiesis and Heart Failure with Preserved Ejection Fraction by Thomas, Toby, Ji, Yuanyuan, Kalkan, Fatma, Son, Albert, Pandey, Ambarish, Subramanian, Vinayak, Premnath, Naveen, Agathocleous, Michalis, Ding, Qing, Bick, Alexander G., Kroger, Benjamin, Tong, Dan, Chung, Stephen S.

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Compound Heterozygosity Involving Other Dead ( DDX) and Deah ( DHX) Box Helicases Explains Seemingly Monoallelic Somatic and Germline DDX41 Mutations by Visconte, Valeria, Bravo-Perez, Carlos, Durmaz, Arda, Guarnera, Luca, Nautiyal, Ishani, Reynold, Megan, Williams, Nakisha D, Kubota, Yasuo, Kawashima, Naomi, Kroger, Benjamin, Chung, Stephen S., Bosler, David S., Gurnari, Carmelo, Maciejewski, Jaroslaw P.

“…DDX41 mutations typify a seemingly distinct group of AML/MDS that appear to differ in many features from wild type entities. Classical DDX41 mutant myeloid…”
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Somatic and Germline HLA Determinants of Immune Surveillance and Escape in Myelodysplastic Syndromes by Gurnari, Carmelo, Durmaz, Arda, Kroger, Benjamin, Awada, Hussein, Chen, Jacky, Hercus, Colin, Hergalant, Sébastien, Bravo-Perez, Carlos, Voso, Maria Teresa, Scott, Jacob, Visconte, Valeria, Chung, Stephen S., Maciejewski, Jaroslaw P., Pagliuca, Simona

“…While the contribution of canonical myeloid genetic drivers to myelodysplastic syndromes/neoplasms (MDS) pathobiology is well established, other genetic events…”
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3177 – CLONAL HEMATOPOIESIS PROMOTES HEART FAILURE WITH PRESERVED EJECTION FRACTION by Thomas, Toby, Pandey, Ambarish, Ji, Yuanyuan, Kroger, Benjamin, Irion, Camila, Kalkan, Fatma, Segar, Matthew, Subramanian, Vinayak, Genis, Antonio, Hu, Wenhuo, Son, Albert, Carlsgaard, Peter, Premnath, Naveen, Jiang, Nan, Daou, Daniel, Ware, Sarah, Tong, Dan, Chung, Stephen

“…Heart failure with preserved ejection fraction (HFpEF) accounts for nearly half of all heart failure, but its etiology is poorly understood. Clonal…”
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3194 – CLONAL HEMATOPOIESIS AS A DRIVER OF HEART FAILURE WITH PRESERVED EJECTION FRACTION by Thomas, Toby, Ji, Yuanyuan, Kalkan, Fatma, Son, Albert, Pandey, Ambarish, Subramanian, Vinayak, Premnath, Naveen, Agathocleous, Michalis, Ding, Qing, Bick, Alexander, Kroger, Benjamin, Tong, Dan, Chung, Stephen

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Evaluating Stem Cells to Predict Post-Transplant Relapse in the Myelodysplastic Syndromes by Kroger, Benjamin, Huang, Yi, Patel, Prapti, Afrough, Aimaz, Kaur, Gurbakhash, Anderson, Larry D., Awan, Farrukh T., Ramakrishnan, Praveen, Verma, Kunal, Vittrup, Russell, Collins, Robert H., Vusirikala, Madhuri, Madanat, Yazan F., Tamari, Roni, Chung, Stephen S.

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Prevalence of Clonal Hematopoiesis in Patients with Monoclonal Gammopathy of Undetermined Significance by Quaney, Vianey, Kroger, Benjamin, Sannareddy, Aishwarya, Khan, Umar, Kalkan, Fatma, Collins, Robert H., Madanat, Yazan F., Vusirikala, Madhuri, Huang, Yi, Awan, Farrukh T., Ramakrishnan, Praveen, Afrough, Aimaz, Anderson, Larry D., Chung, Stephen S., Kaur, Gurbakhash

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RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax by Sango, Junya, Carcamo, Saul, Sirenko, Maria, Maiti, Abhishek, Mansour, Hager, Ulukaya, Gulay, Tomalin, Lewis E, Cruz-Rodriguez, Nataly, Wang, Tiansu, Olszewska, Malgorzata, Olivier, Emmanuel, Jaud, Manon, Nadorp, Bettina, Kroger, Benjamin, Hu, Feng, Silverman, Lewis, Chung, Stephen S, Wagenblast, Elvin, Chaligne, Ronan, Eisfeld, Ann-Kathrin, Demircioglu, Deniz, Landau, Dan A, Lito, Piro, Papaemmanuil, Elli, DiNardo, Courtney D, Hasson, Dan, Konopleva, Marina, Papapetrou, Eirini P

“…Cancer driver mutations often show distinct temporal acquisition patterns, but the biological basis for this, if any, remains unknown. RAS mutations occur…”
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3106 – RESIDUAL MUTANT HEMATOPOIETIC STEM CELLS DRIVES POST-TRANSPLANT RELAPSE OF THE MYELODYSPLASTIC SYNDROMES by Kroger, Benjamin, Son, Albert, Huang, Yi, Patel, Prapti, Afrough, Aimaz, Kaur, Gurbakhash, Anderson, Larry, Awan, Farrukh, Ramakrishnan, Praveen, Verma, Kunal, Vittrup, Russell, Collins, Robert, Vusirikala, Madhuri, Madanat, Yazan, Gurnari, Carmelo, Maciejewski, Jaroslaw, Tamari, Roni, Chung, Stephen

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Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques by Bronk, Lawrence, Guan, Fada, Patel, Darshana, Ma, Duo, Kroger, Benjamin, Wang, Xiaochun, Tran, Kevin, Yiu, Joycelyn, Stephan, Clifford, Debus, Jürgen, Abdollahi, Amir, Jäkel, Oliver, Mohan, Radhe, Titt, Uwe, Grosshans, David R

“…Large amounts of high quality biophysical data are needed to improve current biological effects models but such data are lacking and difficult to obtain. The…”
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Abstract 65: Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade by Gu, Shengqing, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason L., Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon J., Rodig, Scott J., Long, Henry, Gewurz, Benjamin E., Hodi, F. Stephen, Brown, Myles, Liu, X. Shirley

“…Abstract Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we…”
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RBE Model-Based Biological Dose Optimization for Proton Radiobiology Studies by Guan, Fada, Geng, Changran, Ma, Duo, Bronk, Lawrence, Kerr, Matthew, Li, Yuting, Gates, Drake, Kroger, Benjamin, Sahoo, Narayan, Titt, Uwe, Grosshans, David, Mohan, Radhe

“…The purpose of the current study was (1) to develop a straightforward and rapid method to incorporate a dose-averaged linear energy transfer (LET )-based…”
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