Search Results - "Kroehling, Lina"

Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease by Lee, June-Yong, Hall, Jason A., Kroehling, Lina, Wu, Lin, Najar, Tariq, Nguyen, Henry H., Lin, Woan-Yu, Yeung, Stephen T., Silva, Hernandez Moura, Li, Dayi, Hine, Ashley, Loke, P’ng, Hudesman, David, Martin, Jerome C., Kenigsberg, Ephraim, Merad, Miriam, Khanna, Kamal M., Littman, Dan R.

“…Lymphoid cells that produce interleukin (IL)-17 cytokines protect barrier tissues from pathogenic microbes but are also prominent effectors of inflammation and…”
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The translation of non-canonical open reading frames controls mucosal immunity by Jackson, Ruaidhrí, Kroehling, Lina, Khitun, Alexandra, Bailis, Will, Jarret, Abigail, York, Autumn G., Khan, Omair M., Brewer, J. Richard, Skadow, Mathias H., Duizer, Coco, Harman, Christian C. D., Chang, Lelina, Bielecki, Piotr, Solis, Angel G., Steach, Holly R., Slavoff, Sarah, Flavell, Richard A.

“…The annotation of the mammalian protein-coding genome is incomplete. Arbitrary size restriction of open reading frames (ORFs) and the absolute requirement for…”
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Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy by Wu, Lin, Hollinshead, Kate E.R., Hao, Yuhan, Au, Christy, Kroehling, Lina, Ng, Charles, Lin, Woan-Yu, Li, Dayi, Silva, Hernandez Moura, Shin, Jong, Lafaille, Juan J., Possemato, Richard, Pacold, Michael E., Papagiannakopoulos, Thales, Kimmelman, Alec C., Satija, Rahul, Littman, Dan R.

“…Targeting glycolysis has been considered therapeutically intractable owing to its essential housekeeping role. However, the context-dependent requirement for…”
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Feeding-dependent VIP neuron–ILC3 circuit regulates the intestinal barrier by Talbot, Jhimmy, Hahn, Paul, Kroehling, Lina, Nguyen, Henry, Li, Dayi, Littman, Dan R.

“…The intestinal mucosa serves both as a conduit for the uptake of food-derived nutrients and microbiome-derived metabolites, and as a barrier that prevents…”
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KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity by Herndler-Brandstetter, Dietmar, Ishigame, Harumichi, Shinnakasu, Ryo, Plajer, Valerie, Stecher, Carmen, Zhao, Jun, Lietzenmayer, Melanie, Kroehling, Lina, Takumi, Akiko, Kometani, Kohei, Inoue, Takeshi, Kluger, Yuval, Kaech, Susan M., Kurosaki, Tomohiro, Okada, Takaharu, Flavell, Richard A.

“…Protective immunity against pathogens depends on the efficient generation of functionally diverse effector and memory T lymphocytes. However, whether…”
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A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation by Kedmi, Ranit, Najar, Tariq A., Mesa, Kailin R., Grayson, Allyssa, Kroehling, Lina, Hao, Yuhan, Hao, Stephanie, Pokrovskii, Maria, Xu, Mo, Talbot, Jhimmy, Wang, Jiaxi, Germino, Joe, Lareau, Caleb A., Satpathy, Ansuman T., Anderson, Mark S., Laufer, Terri M., Aifantis, Iannis, Bartleson, Juliet M., Allen, Paul M., Paidassi, Helena, Gardner, James M., Stoeckius, Marlon, Littman, Dan R.

“…The mutualistic relationship of gut-resident microbiota and the host immune system promotes homeostasis that ensures maintenance of the microbial community and…”
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Transcription factor RORα enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element by Hall, Jason A., Pokrovskii, Maria, Kroehling, Lina, Kim, Bo-Ram, Kim, Seung Yong, Wu, Lin, Lee, June-Yong, Littman, Dan R.

“…T helper 17 (Th17) cells regulate mucosal barrier defenses but also promote multiple autoinflammatory diseases. Although many molecular determinants of Th17…”
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Skin-resident innate lymphoid cells converge on a pathogenic effector state by Bielecki, Piotr, Riesenfeld, Samantha J., Hütter, Jan-Christian, Torlai Triglia, Elena, Kowalczyk, Monika S., Ricardo-Gonzalez, Roberto R., Lian, Mi, Amezcua Vesely, Maria C., Kroehling, Lina, Xu, Hao, Slyper, Michal, Muus, Christoph, Ludwig, Leif S., Christian, Elena, Tao, Liming, Kedaigle, Amanda J., Steach, Holly R., York, Autumn G., Skadow, Mathias H., Yaghoubi, Parastou, Dionne, Danielle, Jarret, Abigail, McGee, Heather M., Porter, Caroline B. M., Licona-Limón, Paula, Bailis, Will, Jackson, Ruaidhrí, Gagliani, Nicola, Gasteiger, Georg, Locksley, Richard M., Regev, Aviv, Flavell, Richard A.

“…Tissue-resident innate lymphoid cells (ILCs) help sustain barrier function and respond to local signals. ILCs are traditionally classified as ILC1, ILC2 or…”
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Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease by Lee, June-Yong, Hall, Jason A., Kroehling, Lina, Wu, Lin, Najar, Tariq, Nguyen, Henry H., Lin, Woan-Yu, Yeung, Stephen T., Silva, Hernandez Moura, Li, Dayi, Hine, Ashley, Loke, P’ng, Hudesman, David, Martin, Jerome C., Kenigsberg, Ephraim, Merad, Miriam, Khanna, Kamal M., Littman, Dan R.

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Abstract 4335: High-resolution characterization of age-specific cell type composition changes and signaling events in HPV-negative HNSCC tumors by Kroehling, Lina, Spinella, Anthony, Kukuruzinska, Maria, Varelas, Xaralabos, Monti, Stefano

“…Abstract This study is aimed at testing the hypothesis that increased patient age fosters conditions that are favorable for head and neck squamous cell…”
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Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection by Amezcua Vesely, Maria Carolina, Pallis, Paris, Bielecki, Piotr, Low, Jun Siong, Zhao, Jun, Harman, Christian C.D., Kroehling, Lina, Jackson, Ruaidhrí, Bailis, Will, Licona-Limón, Paula, Xu, Hao, Iijima, Norifumi, Pillai, Padmini S., Kaplan, Daniel H., Weaver, Casey T., Kluger, Yuval, Kowalczyk, Monika S., Iwasaki, Akiko, Pereira, Joao P., Esplugues, Enric, Gagliani, Nicola, Flavell, Richard A.

“…Adaptive immunity provides life-long protection by generating central and effector memory T cells and the most recently described tissue resident memory T…”
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Abstract PO-017: Targeting murine oral tumors by pharmacological inhibition of b-catenin/CBP epigenetic activity by Khan, Mohammed Muzamil, Reed, Eric, Kroehling, Lina, Bais, Manish, Varelas, Xaralabos, Kukuruzinska, Maria, Monti, Stefano

“…Abstract In previous studies, we have shown that pharmacological blockade of Wnt/β-catenin/CBP activity with small molecule inhibitors is effective in…”
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Abstract LB288: Reducing the effect of cellular stress in murine oral tumors with pharmacological blockade of β-catenin/CBP activity by Khan, Mohammed Muzamil, Reed, Eric, Kroehling, Lina, Nomoto, Kenichi, Matsui, Junji, Bais, Manish, Varelas, Xaralabos, Kukuruzinska, Maria, Monti, Stefano

“…Abstract Oral squamous cell carcinoma (OSCC), a primary subtype of head and neck squamous cell carcinoma (HNSCC), is a complex malignancy comprising multiple…”
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Publisher Correction: A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation by Kedmi, Ranit, Najar, Tariq A., Mesa, Kailin R., Grayson, Allyssa, Kroehling, Lina, Hao, Yuhan, Hao, Stephanie, Pokrovskii, Maria, Xu, Mo, Talbot, Jhimmy, Wang, Jiaxi, Germino, Joe, Lareau, Caleb A., Satpathy, Ansuman T., Anderson, Mark S., Laufer, Terri M., Aifantis, Iannis, Bartleson, Juliet M., Allen, Paul M., Paidassi, Helena, Gardner, James M., Stoeckius, Marlon, Littman, Dan R.

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c-MAF-dependent perivascular macrophages regulate diet-induced metabolic syndrome by Moura Silva, Hernandez, Kitoko, Jamil Zola, Queiroz, Camila Pereira, Kroehling, Lina, Matheis, Fanny, Yang, Katharine Lu, Reis, Bernardo S, Ren-Fielding, Christine, Littman, Dan R, Bozza, Marcelo Torres, Mucida, Daniel, Lafaille, Juan J

“…Macrophages are an essential part of tissue development and physiology. Perivascular macrophages have been described in tissues and appear to play a role in…”
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Effector T H 17 Cells Give Rise to Long-Lived T RM Cells that Are Essential for an Immediate Response against Bacterial Infection by Amezcua Vesely, Maria Carolina, Pallis, Paris, Bielecki, Piotr, Low, Jun Siong, Zhao, Jun, Harman, Christian C D, Kroehling, Lina, Jackson, Ruaidhrí, Bailis, Will, Licona-Limón, Paula, Xu, Hao, Iijima, Norifumi, Pillai, Padmini S, Kaplan, Daniel H, Weaver, Casey T, Kluger, Yuval, Kowalczyk, Monika S, Iwasaki, Akiko, Pereira, Joao P, Esplugues, Enric, Gagliani, Nicola, Flavell, Richard A

“…Adaptive immunity provides life-long protection by generating central and effector memory T cells and the most recently described tissue resident memory T (T )…”
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YYSkin-resident innate lymphoid cells converge on a pathogenic effector state by Bielecki, P, Riesenfeld, SJ, Hutter, JC, Triglia, ET, Kowalczyk, MS, Ricardo-Gonzalez, RR, Lian, M, Vesely, MCA, Kroehling, L, Xu, H, Slyper, M, Muus, C, Ludwig, LS, Christian, E, Tao, LM, Kedaigle, AJ, Steach, HR, York, AG, Skadow, MH, Yaghoubi, P, Dionne, D, Jarret, A, McGee, HM, Porter, CBM, Licona-Limon, P, Bailis, W, Jackson, R, Gagliani, N, Gasteiger, G, Locksley, RM, Regev, A, Flavell, RA

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m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways by Li, Hua-Bing, Tong, Jiyu, Zhu, Shu, Batista, Pedro J., Duffy, Erin E., Zhao, Jun, Bailis, Will, Cao, Guangchao, Kroehling, Lina, Chen, Yuanyuan, Wang, Geng, Broughton, James P., Chen, Y. Grace, Kluger, Yuval, Simon, Matthew D., Chang, Howard Y., Yin, Zhinan, Flavell, Richard A.

“…The authors assess the role of N 6 -methyladenosine in T cell development and function, and show that RNA methylation controls T cell homeostasis by regulating…”
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m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway by Li, Hua-Bing, Tong, Jiyu, Zhu, Shu, Batista, Pedro J., Duffy, Erin E., Zhao, Jun, Bailis, Will, Cao, Guangchao, Kroehling, Lina, Chen, Yuanyuan, Wang, Geng, Broughton, James P., Chen, Y. Grace, Kluger, Yuval, Simon, Matthew D., Chang, Howard Y., Yin, Zhinan, Flavell, Richard A.

“…N6 -methyladenosine (m 6 A) is the most common and abundant messenger RNA modification, modulated by ‘writers’, ‘erasers’ and ‘readers’ of this mark 1 , 2 . In…”
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A RORγt + cell instructs gut microbiota-specific T reg cell differentiation by Kedmi, Ranit, Najar, Tariq A, Mesa, Kailin R, Grayson, Allyssa, Kroehling, Lina, Hao, Yuhan, Hao, Stephanie, Pokrovskii, Maria, Xu, Mo, Talbot, Jhimmy, Wang, Jiaxi, Germino, Joe, Lareau, Caleb A, Satpathy, Ansuman T, Anderson, Mark S, Laufer, Terri M, Aifantis, Iannis, Bartleson, Juliet M, Allen, Paul M, Paidassi, Helena, Gardner, James M, Stoeckius, Marlon, Littman, Dan R

“…The mutualistic relationship of gut-resident microbiota and the host immune system promotes homeostasis that ensures maintenance of the microbial community and…”
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