Search Results - "Kroczek, R"

Lymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells by Cerovic, V, Houston, S A, Westlund, J, Utriainen, L, Davison, E S, Scott, C L, Bain, C C, Joeris, T, Agace, W W, Kroczek, R A, Mowat, A M, Yrlid, U, Milling, S WF

“…Cross-presentation of cellular antigens is crucial for priming CD8 + T cells, and generating immunity to intracellular pathogens—particularly viruses. It is…”
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ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28 by Kroczek, Richard A, Hutloff, Andreas, Dittrich, Anna M, Beier, Katja C, Eljaschewitsch, Barbara, Kraft, Regine, Anagnostopoulos, Ionnis

“…The T-cell-specific cell-surface receptors CD28 and CTLA-4 are important regulators of the immune system. CD28 potently enhances those T-cell functions that…”
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Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency by Peter, Hans H, Grimbacher, Bodo, Hutloff, Andreas, Schlesier, Michael, Glocker, Erik, Warnatz, Klaus, Dräger, Ruth, Eibel, Hermann, Fischer, Beate, Schäffer, Alejandro A, Mages, Hans W, Kroczek, Richard A

“…No genetic defect is known to cause common variable immunodeficiency (CVID), a heterogeneous human disorder leading to adult-onset panhypogammaglobulinemia. In…”
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CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells by Kroczek, Richard A, Henn, Volker, Slupsky, Joseph R, Gräfe, Michael, Anagnostopoulos, Ioannis, Förster, Reinhold, Müller-Berghaus, Gert

“…CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the cytokine TNF-α, was originally identified on stimulated CD4+ T cells, and later…”
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Chemokine-receptor expression on T cells in lung compartments of challenged asthmatic patients by Kallinich, T., Schmidt, S., Hamelmann, E., Fischer, A., Qin, S., Luttmann, W., Virchow, J. C., Kroczek, R. A.

“…Summary Background The interaction of chemokines with their receptors strongly influences the migration of leucocytes. Objective In order to assess the…”
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Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40 by Slupsky, J R, Kalbas, M, Willuweit, A, Henn, V, Kroczek, R A, Müller-Berghaus, G

“…CD40 is a type I member of the tumour necrosis factor (TNF) receptor superfamily of proteins, and is present on a wide variety of cells including vascular…”
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Production of IL-12 by Human Monocyte-Derived Dendritic Cells Is Optimal When the Stimulus Is Given at the Onset of Maturation, and Is Further Enhanced by IL-4 by Ebner, Susanne, Ratzinger, Gudrun, Krosbacher, Beate, Schmuth, Matthias, Weiss, Angelika, Reider, Daniela, Kroczek, Richard A, Herold, Manfred, Heufler, Christine, Fritsch, Peter, Romani, Nikolaus

“…Dendritic cells produce IL-12 both in response to microbial stimuli and to T cells, and can thus skew T cell reactivity toward a Th1 pattern. We investigated…”
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The inflammatory action of CD40 ligand (CD154) expressed on activated human platelets is temporally limited by coexpressed CD40 by Henn, Volker, Steinbach, Sabine, Büchner, Kerstin, Presek, Peter, Kroczek, Richard A.

“…Recently, we have demonstrated that human platelets carry preformed CD40 ligand (CD154) molecules, which rapidly appear on the platelet surface following…”
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House dust mite-specific T cells in healthy non-atopic children by Bullens, D. M. A., De. Swerdt, A., Dilissen, E., Kasran, A., Kroczek, R. A., Cadot, P., Casaer, P., Ceuppens, J. L.

“…Summary Background T‐helper type 2 (Th2) cells play an important role in the pathogenesis of allergic diseases. Recent studies have demonstrated that…”
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Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM by Korthäuer, Ulf, Graf, Daniel, Mages, Hans W, Brière, Francine, Padayachee, Munoreedevi, Malcolm, Sue, Ugazio, Alberto G, Notarangelo, Luigi D, Levinsky, Roland J, Kroczek, Richard A

“…X chromosome-linked immunodeficiency with hyper-IgM (HIGM1, MIM number 308230) is a rare disorder characterized by recurrent bacterial infections, very low or…”
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Emerging paradigms of T-cell co-stimulation by Kroczek, Richard A, Mages, Hans Werner, Hutloff, Andreas

“…The analysis of recent data reveals that T-cell co-stimulation is a hierarchical process with elements of mutual interdependence between individual…”
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Co-stimulatory molecules as potential targets for therapeutic intervention in allergic airway disease by Kallinich, T., Beier, K. C., Gelfand, E. W., Kroczek, R. A., Hamelmann, E.

“…Summary Airway inflammation is a characteristic feature of allergic asthma. Central to the initiation and progression of the inflammatory process are…”
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MIP-1α, MIP-1β, RANTES, and ATAC/Lymphotactin Function Together with IFN-γ as Type 1 Cytokines by Dorner, Brigitte G., Scheffold, Alexander, Rolph, Michael S., Hüser, Martin B., Stefan H. E. Kaufmann, Radbruch, Andreas, Inge E. A. Flesch, Kroczek, Richard A.

“…We analyzed for the first time the expression of chemokines in subpopulations of the murine immune system at the single-cell level. We demonstrate in vitro and…”
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Cloning of TRAP, a ligand for CD40 on human T cells by Graf, D, Korthäuer, U, Mages, H W, Senger, G, Kroczek, R A

“…A cDNA clone, designated TRAP (TNF-related activation protein) was isolated from a collection of T cell activation genes. The polypeptide encoded by a mRNA of…”
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CD154 stimulation of interleukin‐12 synthesis in human endothelial cells by Lienenlüke, Bianca, Germann, Tieno, Kroczek, Richard A., Hecker, Markus

“…The interaction of proinflammatory type 1 T helper (Th1) cells expressing the CD40 ligand (CD154) with endothelial cells expressing the corresponding receptor…”
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Coordinate Expression of Cytokines and Chemokines by NK Cells during Murine Cytomegalovirus Infection by Dorner, Brigitte G, Smith, Hamish R.C, French, Anthony R, Kim, Sungjin, Poursine-Laurent, Jennifer, Beckman, Diana L, Pingel, Jeanette T, Kroczek, Richard A, Yokoyama, Wayne M

“…Cytokines and chemokines activate and direct effector cells during infection. We previously identified a functional group of five cytokines and chemokines,…”
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Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand by Mages, Hans W., Hutloff, Andreas, Heuck, Christoph, Büchner, Kerstin, Himmelbauer, Heinz, Oliveri, Filippo, Kroczek, Richard A.

“…Human ICOS (huICOS) is a T cell‐specific molecule structurally related to CD28 and CTLA‐4 with potent co‐stimulatory activities on T cell proliferation,…”
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Induction, binding specificity and function of human ICOS by Beier, Katja C., Hutloff, Andreas, Dittrich, Anna M., Heuck, Christoph, Rauch, Anita, Büchner, Kerstin, Ludewig, Burkhard, Ochs, Hans D., Mages, Hans W., Kroczek, Richard A.

“…Recently, we have identified the inducible co‐stimulator (ICOS), an activation‐dependent, T cell‐specific cell surface molecule related to CD28 and CTLA‐4…”
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ICOS and CD28 reversely regulate IL‐10 on re‐activation of human effector T cells with mature dendritic cells by Witsch, Esther J., Peiser, Matthias, Hutloff, Andreas, Büchner, Kerstin, Dorner, Brigitte G., Jonuleit, Helmut, Mages, Hans W., Kroczek, Richard A.

“…With newly generated ICOS‐ligand (ICOS‐L)‐specific monoclonal antibodies we determined that human Langerhans cells in situ express similar levels of ICOS‐L,…”
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Defective expression of CD40 ligand on T cells causes "X-linked immunodeficiency with hyper-IgM (HIGM1)" by Kroczek, R A, Graf, D, Brugnoni, D, Giliani, S, Korthüer, U, Ugazio, A, Senger, G, Mages, H W, Villa, A, Notarangelo, L D

“…X-linked immunodeficiency with hyper-IgM (HIGM1) is a rare disorder, characterized by recurrent infections associated with very low or absent IgG and IgA, and…”
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