Search Results - "Kriwacki, R. W."

Direct detection of carbon and nitrogen nuclei for high-resolution analysis of intrinsically disordered proteins using NMR spectroscopy by Gibbs, E.B., Kriwacki, R.W.

“…[Display omitted] •NMR detection schemes can be tailored to the unique linewidth features of IDPs.•15N-detection often offers enhanced resolution over 1H- or…”
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A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer by Kriwacki, Richard W, DiGiammarino, Enrico L, Lee, Amanda S, Cadwell, Craig, Zhang, Weixing, Bothner, Brian, Ribeiro, Raul C, Zambetti, Gerard

“…The p53 tumor suppressor requires tetramerization to function as an initiator of cell cycle arrest and/or apoptosis. Children in southern Brazil that exhibit…”
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Sequence-Specific Recognition of DNA by Zinc-Finger Peptides Derived from the Transcription Factor Sp1 by Kriwacki, Richard W., Schultz, Steve C., Steitz, Thomas A., Caradonna, John P.

“…We have overexpressed and purified two peptide fragments of Sp1 that contain the three "zinc-finger" domains necessary for specific Sp1 DNA binding. These…”
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Solution Structure of the Transcriptional Activation Domain of the Bacteriophage T4 Protein, MotA by Li, Ning, Zhang, Weixing, White, Stephen W, Kriwacki, Richard W

“…Bacteriophage T4 encodes a transcription factor, MotA, that binds to the −30 region of middle-mode promoters and activates transcription by host RNA…”
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Cooperative Signals Governing ARF-Mdm2 Interaction and Nucleolar Localization of the Complex by Weber, Jason D., Kuo, Mei-Ling, Bothner, Brian, DiGiammarino, Enrico L., Kriwacki, Richard W., Roussel, Martine F., Sherr, Charles J.

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Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae by Luo, Rensheng, Mann, Beth, Lewis, William S, Rowe, Arthur, Heath, Richard, Stewart, Michael L, Hamburger, Agnes E, Sivakolundu, Siva, Lacy, Eilyn R, Bjorkman, Pamela J, Tuomanen, Elaine, Kriwacki, Richard W

“…Streptococcus pneumoniae (pneumococcus) remains a significant health threat worldwide, especially to the young and old. While some of the biomolecules involved…”
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Structure and Dynamics of Thioguanine-modified Duplex DNA by Somerville, Lilla, Krynetski, Eugene Y, Krynetskaia, Natalia F, Beger, Richard D, Zhang, Weixing, Marhefka, Craig A, Evans, William E, Kriwacki, Richard W

“…Mercaptopurine and thioguanine, two of the most widely used antileukemic agents, exert their cytotoxic, therapeutic effects by being incorporated into DNA as…”
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Defining the molecular basis of Arf and Hdm2 interactions by Bothner, B, Lewis, W S, DiGiammarino, E L, Weber, J D, Bothner, S J, Kriwacki, R W

“…Understanding the interaction of Arf and Hdm2 has recently become a central issue in cancer biology. In response to hyperproliferative signals, p14(Arf)…”
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Reversible Amyloid Formation by the p53 Tetramerization Domain and a Cancer-associated Mutant by Lee, Amanda S., Galea, Charles, DiGiammarino, Enrico L., Jun, Bokkyoo, Murti, Gopal, Ribeiro, Raul C., Zambetti, Gerard, Schultz, Christian P., Kriwacki, Richard W.

“…The tetramerization domain for wild-type p53 (p53tet-wt) and a p53 mutant, R337H (p53tet-R337H), associated with adrenocortical carcinoma (ACC) in children,…”
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Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition by Narayan, V A, Kriwacki, R W, Caradonna, J P

“…The carboxyl terminus of transcription factor Sp1 contains three contiguous Cys2-His2 zinc finger domains with the consensus sequence…”
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Structure, Activity, and Distribution of Fish Osteocalcin by Nishimoto, Satoru K, Waite, J Herbert, Nishimoto, Miyako, Kriwacki, Richard W

“…Osteocalcin (bone Gla protein) is an extracellular matrix protein synthesized by osteoblasts that is a marker of bone. Osteocalcin probably originated in the…”
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The Sum Is More Than The Parts: Crystal And Solution Data Reveal That The PIDDosome Core Complex Is a Dynamic Assembly by Sprangers, Remco

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Probing protein-protein interactions with mass spectrometry by Kriwacki, R W, Siuzdak, G

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Current aspects of practical two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy: applications to structure elucidation by KRIWACKI, R. W, PHIL PITNER, T

“…The intense effort in developing new 2D NMR methodology over the past decade has been driven by the desire to study molecules of progressively greater…”
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Repression of TFIIH Transcriptional Activity and TFIIH-Associated cdk7 Kinase Activity at Mitosis by Long, John J., Leresche, Anne, Kriwacki, Richard W., Gottesfeld, Joel M.

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NMR solution structure of the inserted domain of human leukocyte function associated antigen-1 by Legge, Glen B., Kriwacki, Richard W., Chung, John, Hommel, Ulrich, Ramage, Paul, Case, David A., Dyson, H.Jane, Wright, Peter E.

“…The interaction between the leukocyte function-associated antigen-1 (LFA-1) and the intercellular adhesion molecule is thought to be mediated primarily via the…”
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Probing protein structure using biochemical and biophysical methods: Proteolysis, matrix-assisted laser desorption/ionization mass spectrometry, high-performance liquid chromatography and size-exclusion chromatography of p21Waf1/Cip1/Sdi1 by Kriwacki, Richard W, Wu, Jiangyue, Tennant, Linda, Wright, Peter E, Siuzdak, Gary

“…The cyclin-dependent kinase (Cdk) inhibitor p21Waf1/Cip1/Sdi1, important for p53 tumor suppressor-dependent cell growth control in humans and other organisms,…”
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Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction by Pettersson, Mariell, Quant, Maria, Min, Jaeki, Iconaru, Luigi, Kriwacki, Richard W, Waddell, M Brett, Guy, R Kiplin, Luthman, Kristina, Grøtli, Morten

“…The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 mutations resulting in a loss of its function. In tumours…”
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8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction by Pettersson, Mariell, Bliman, David, Jacobsson, Jimmy, Nilsson, Jesper R, Min, Jaeki, Iconaru, Luigi, Guy, R Kiplin, Kriwacki, Richard W, Andréasson, Joakim, Grøtli, Morten

“…Small molecule nonpeptidic mimics of α-helices are widely recognised as protein-protein interaction (PPIs) inhibitors. Protein-protein interactions mediate…”
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New NMR methods for the characterization of bound waters in macromolecules by Kriwacki, Richard W, Hill, R. Blake, Flanagan, John M, Caradonna, John P, Prestegard, James H

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