Study of the adjuvant activity of new MDP derivatives and purified saponins and their influence on HIV-1 replication in vitro

Muramyl dipeptide (MDP), eight new lipophilic MDP derivatives (MDPs) and three purified saponins were evaluated for their ability to induce immune responses in mice immunized with HIV-1 envelope protein rgp160 and for their ability to influence the HIV-1 replication in vitro. Three of nine new synth...

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Published in:	Vaccine Vol. 15; no. 12; pp. 1479 - 1486
Main Authors:	Krivorutchenko, Yuri L., Andronovskaja, Irina B., Hinkula, Jorma, Krivoshein, Yuri S., Ljungdahl-Ståhle, Ewa, Pertel, Sergey S., Grishkovets, Vladimir I., Zemlyakov, Alexander E., Wahren, Britta
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01-08-1997 Elsevier
Subjects:	Acetylmuramyl-Alanyl-Isoglutamine - analogs & derivatives Acetylmuramyl-Alanyl-Isoglutamine - pharmacology adjuvants Adjuvants, Immunologic - pharmacology AIDS/HIV Animals Biological and medical sciences Female Fundamental and applied biological sciences. Psychology HIV-1 HIV-1 - drug effects HIV-1 - physiology human immunodeficiency virus 1 Male Medicin och hälsovetenskap Mice Mice, Inbred BALB C Microbiology muramyl dipeptide derivatives saponins Saponins - pharmacology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Virology Virus Replication - drug effects HIV-1 muramyl dipeptide derivatives adjuvants saponins Immunopathology Immunostimulation HIV-1 virus Rodentia Retroviridae AIDS Vaccine Immune deficiency Saponin Infection Virus Vertebrata Mammalia Immunogenicity Mouse Viral disease Immunological adjuvant In vitro replication Lentivirinae Human immunodeficiency virus Inhibition Humoral immunity
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Summary:	Muramyl dipeptide (MDP), eight new lipophilic MDP derivatives (MDPs) and three purified saponins were evaluated for their ability to induce immune responses in mice immunized with HIV-1 envelope protein rgp160 and for their ability to influence the HIV-1 replication in vitro. Three of nine new synthetic MDP derivatives (β-butyl-MDP, MTPO-26 and β-cholesteryl-MDP) and one saponin (Taurosid I) have been shown to induce strong humoral immune responses to HIV-1 envelope glycoproteins rgp160 and rgp120. Three substances (β-butyl-MDP, MDP-cholyl and β-G27-MDP) induced high levels of T-cell stimulation to HIV-1 rgp160. β-butyl-MDP induced the strongest B- and T-cell responses to HIV-1 glycoproteins. Two substances (β-butyl-MDP and Taurosid I) did not induce an enhancement of HIV-1 replication in vitro and can be considered as promising adjuvants.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0264-410X 1873-2518
DOI:	10.1016/S0264-410X(97)00065-0