Search Results - "Kristo, Fjoralba"

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis by Najafi-Shoushtari, S. Hani, Kristo, Fjoralba, Li, Yingxia, Shioda, Toshi, Cohen, David E, Gerszten, Robert E, Näär, Anders M

“…Proper coordination of cholesterol biosynthesis and trafficking is essential to human health. The sterol regulatory element-binding proteins (SREBPs) are key…”
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Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis by Wagschal, Alexandre, Najafi-Shoushtari, S Hani, Wang, Lifeng, Goedeke, Leigh, Sinha, Sumita, deLemos, Andrew S, Black, Josh C, Ramírez, Cristina M, Li, Yingxia, Tewhey, Ryan, Hatoum, Ida, Shah, Naisha, Lu, Yong, Kristo, Fjoralba, Psychogios, Nikolaos, Vrbanac, Vladimir, Lu, Yi-Chien, Hla, Timothy, de Cabo, Rafael, Tsang, John S, Schadt, Eric, Sabeti, Pardis C, Kathiresan, Sekar, Cohen, David E, Whetstine, Johnathan, Chung, Raymond T, Fernández-Hernando, Carlos, Kaplan, Lee M, Bernards, Andre, Gerszten, Robert E, Näär, Anders M

“…From a systematic analysis of genome-wide association studies of blood lipid levels, Wagschal et al . identify several miRNAs that target key proteins involved…”
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Time without transfusion reliance: a novel patient-centric metric for new therapies in myelodysplastic syndromes by Zeidner, Joshua F, Mazerolle, Flora, Norton, Jonathan, Regnault, Antoine, Kristo, Fjoralba, Romero, Heather, Fram, Robert J, Faller, Douglas V, Dalal, Mehul, Ades, Lionel, Sekeres, Mikkael A

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Inhibited Aortic Aneurysm Formation in BLT1-Deficient Mice by Ahluwalia, Neil, Lin, Alexander Y, Tager, Andrew M, Pruitt, Ivy E, Anderson, Thomas J. T, Kristo, Fjoralba, Shen, Dongxiao, Cruz, Anna R, Aikawa, Masanori, Luster, Andrew D, Gerszten, Robert E

“…Leukotriene B(4) is a proinflammatory lipid mediator generated by the enzymes 5-lipoxygenase and leukotriene A(4) hydrolase. Leukotriene B(4) signals primarily…”
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Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation by Kristo, Fjoralba, Hardy, Gregory J, Anderson, Thomas J.T, Sinha, Sumita, Ahluwalia, Neil, Lin, Alexander Y, Passeri, Jonathan, Scherrer-Crosbie, Marielle, Gerszten, Robert E

“…Abstract Leukotriene B4 (LTB4 ) is a pro-inflammatory lipid mediator generated by the enzymes 5-lipoxygenase (5-LO) and LTA4 -hydrolase. LTB4 signals primarily…”
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Real-World Treatment Patterns and Patient Outcomes in Relapsed/Refractory Hodgkin Lymphoma in the US by Kristo, Fjoralba, Lingohr-Smith, Melissa, Lin, Jay, Ashaye, Ajibade

“…Introduction Brentuximab vedotin (BV), a CD30-directed monoclonal antibody, and programmed cell death-1 inhibitors (PD-1; e.g., nivolumab, pembrolizumab) are…”
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The Comparative Effectiveness of A+AVD vs PET-guided ABVD for the Management of Patients with Advanced Hodgkin Lymphoma: A Systematic Review and Matching-Adjusted Indirect Treatment Comparison by Kristo, Fjoralba, Paly, Victoria Federico, Fazioli, Katherine, McCloskey, Conor, Nair, Sunita, Savani, Bipin N., Zomas, Athanasios, Ashaye, Ajibade

“…Introduction: In advanced Hodgkin lymphoma (aHL), adriamycin (doxorubicin), bleomycin, vinblastine, and dacarbazine (ABVD) is a recommended chemotherapy…”
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Clinical impact of transformation to acute myeloid leukemia in patients with higher-risk myelodysplastic syndromes by Kota, Vamsi, Ogbonnaya, Augustina, Farrelly, Eileen, Schroader, Bridgette Kanz, Raju, Aditya, Kristo, Fjoralba, Dalal, Mehul

“…Forty percent of patients with higher-risk myelodysplastic syndromes (HR-MDS) transform to acute myeloid leukemia (AML). This retrospective study assessed the…”
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Economic Impact of Transformation to Acute Myeloid Leukemia Among Actively Managed Patients with Higher-Risk Myelodysplastic Syndromes in the United States by Kota, Vamsi, Ogbonnaya, Augustina, Farrelly, Eileen, Schroader, Bridgette Kanz, Raju, Aditya, Kristo, Fjoralba, Dalal, Mehul

“…Introduction Transformation of higher-risk myelodysplastic syndromes (MDS) to acute myeloid leukemia (AML) may be associated with increased healthcare resource…”
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MDS-357: Impact of Transformation to Acute Myeloid Leukemia (AML) on Overall Survival (OS) among Patients with Higher-Risk Myelodysplastic Syndromes (HR-MDS) in the United States of America (USA) by Kota, Vamsi, Ogbonnaya, Augustina, Farrelly, Eileen, Schroader, Bridgette, Kristo, Fjoralba, Raju, Aditya, Dalal, Mehul

“…Post hoc analyses of a randomized phase 2 trial (NCT02610777) that compared pevonedistat+azacitidine versus azacitidine alone demonstrated that transformation…”
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Poster: MDS-357: Impact of Transformation to Acute Myeloid Leukemia (AML) on Overall Survival (OS) among Patients with Higher-Risk Myelodysplastic Syndromes (HR-MDS) in the United States of America (USA) by Kota, Vamsi, Ogbonnaya, Augustina, Farrelly, Eileen, Schroader, Bridgette, Kristo, Fjoralba, Raju, Aditya, Dalal, Mehul

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Playing the Role of the Scrub Nurse by Junior Surgery Residents in the Operating Room Improves Their Technical and Nontechnical Skills by Nelson, Benjamin, Kim, Na Eun, Sullivan, Brandy L., Kristo, Fjoralba, O'Neal, Patrick B., Sanchez, Vivian M., Whang, Edward E., Kristo, Gentian

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Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture by King, Victoria L, Lin, Alexander Y, Kristo, Fjoralba, Anderson, Thomas J T, Ahluwalia, Neil, Hardy, Gregory J, Owens, 3rd, A Phillip, Howatt, Deborah A, Shen, Dongxiao, Tager, Andrew M, Luster, Andrew D, Daugherty, Alan, Gerszten, Robert E

“…Vascular disease can manifest as stenotic plaques or ectatic aneurysms, although the mechanisms culminating in these divergent disease manifestations remain…”
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Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice by Uchida, Haruhito A, Kristo, Fjoralba, Rateri, Debra L, Lu, Hong, Charnigo, Richard, Cassis, Lisa A, Daugherty, Alan

“…Abstract Objective T and B lymphocytes are associated with atherosclerosis and aneurysms. Angiotensin II (AngII) infusion into hypercholesterolemic mice…”
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MicroRNAs in metabolism and metabolic diseases by Rottiers, V, Najafi-Shoushtari, S H, Kristo, F, Gurumurthy, S, Zhong, L, Li, Y, Cohen, D E, Gerszten, R E, Bardeesy, N, Mostoslavsky, R, Näär, A M

“…Aberrant cholesterol/lipid homeostasis is linked to a number of diseases prevalent in the developed world, including metabolic syndrome, type II diabetes, and…”
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Conserved Gene Regulatory Mechanisms Controlling Cholesterol and Fat by Näär, Anders M., Walker, Amy K., Yang, Fajun, Najafi‐Shoushtari, S. Hani, Rottiers, Veerle, Kristo, Fjoralba, Li, Yingxia, Shioda, Toshi, Cohen, David E., Gerszten, Robert E.

“…Proper coordination of cholesterol/lipid biosynthesis, trafficking, and degradation is essential to human health. The sterol regulatory element–binding…”
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Interferon-y and the Interferon-Inducible Chemokine CXCL10 Protect Against Aneurysm Formation and Rupture by KING, Victoria L, LIN, Alexander Y, LUSTER, Andrew D, DAUGHERTY, Alan, GERSZTEN, Robert E, KRISTO, Fjoralba, ANDERSON, Thomas J. T, AHLUWALIA, Neil, HARDY, Gregory J, OWENS, A. Phillip, HOWATT, Deborah A, DONGXIAO SHEN, TAGER, Andrew M

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