Search Results - "Kristian, Alexandr"

B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation by Liu, Hao, Tekle, Christina, Chen, Yih-Wen, Kristian, Alexandr, Zhao, Yuhua, Zhou, Ming, Liu, Zixing, Ding, Yan, Wang, Bin, Mælandsmo, Gunhild Mari, Nesland, Jahn Marthin, Fodstad, Oystein, Tan, Ming

“…In many types of cancer, the expression of the immunoregulatory protein B7-H3 has been associated with poor prognosis. Previously, we observed a link between…”
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Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist by Pitman, Kathinka E, Bakke, Kine M, Kristian, Alexandr, Malinen, Eirik

“…Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) may be used to depict tumour vascular structure and for therapy response assessment in various…”
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Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer by Jin, Yang, Qu, Su, Tesikova, Martina, Wang, Ling, Kristian, Alexandr, Mælandsmo, Gunhild M, Kong, Haiying, Zhang, Tianzhou, Jerónimo, Carmen, Teixeira, Manuel R, Yuca, Erkan, Tekedereli, Ibrahim, Gorgulu, Kivanc, Alpay, Neslihan, Sood, Anil K, Lopez-Berestein, Gabriel, Danielsen, Håvard E, Ozpolat, Bulent, Saatcioglu, Fahri

“…The androgen receptor (AR) and the phosphoinositide 3-kinase (PI3K)/protein kinase B/mammalian target of rapamycin (mTOR) signaling are two of the major…”
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Liver X receptors induce antiproliferative effects in basal-like breast cancer by Haugen, Mads Haugland, von der Lippe Gythfeldt, Hedda, Egeland, Eivind Valen, Svartdal Normann, Lisa, Pandya, Abhilash D, Vedin, Lise-Lotte, Juell, Siri, Tenstad, Ellen, Øy, Geir Frode, Kristian, Alexandr, Marangoni, Elisabetta, Sørlie, Therese, Steffensen, Knut, Maelandsmo, Gunhild Mari, Engebraaten, Olav

“…Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The…”
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Proteomic Characterization of Breast Cancer Xenografts Identifies Early and Late Bevacizumab-Induced Responses and Predicts Effective Drug Combinations by LINDHOLM, Evita M, KROHN, Marit, IADEVAIA, Sergio, KRISTIAN, Alexandr, MILLS, Gordon B, MNLANDSMO, Gunhild M, ENGEBRAATEN, Olav

“…Neoangiogenesis is an important feature in tumor growth and progression, and combining chemotherapy and antiangiogenic drugs have shown clinical efficacy…”
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Aldehyde dehydrogenase (ALDH) activity does not select for cells with enhanced aggressive properties in malignant melanoma by Prasmickaite, Lina, Engesaeter, Birgit Ø, Skrbo, Nirma, Hellenes, Tina, Kristian, Alexandr, Oliver, Nina K, Suo, Zhenhe, Maelandsmo, Gunhild M

“…Malignant melanoma is an exceptionally aggressive, drug-resistant and heterogeneous cancer. Recently it has been shown that melanoma cells with high clonogenic…”
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STAMP2 increases oxidative stress and is critical for prostate cancer by Jin, Yang, Wang, Ling, Qu, Su, Sheng, Xia, Kristian, Alexandr, Mælandsmo, Gunhild M, Pällmann, Nora, Yuca, Erkan, Tekedereli, Ibrahim, Gorgulu, Kivanc, Alpay, Neslihan, Sood, Anil, Lopez‐Berestein, Gabriel, Fazli, Ladan, Rennie, Paul, Risberg, Bjørn, Wæhre, Håkon, Danielsen, Håvard E, Ozpolat, Bulent, Saatcioglu, Fahri

“…The six transmembrane protein of prostate 2 ( STAMP2) is an androgen‐regulated gene whose mRNA expression is increased in prostate cancer (PCa). Here, we show…”
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Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer by Moestue, Siver A, Dam, Cornelia G, Gorad, Saurabh S, Kristian, Alexandr, Bofin, Anna, Mælandsmo, Gunhild M, Engebråten, Olav, Gribbestad, Ingrid S, Bjørkøy, Geir

“…The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in cancer cells through numerous mutations and epigenetic changes. The recent…”
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Antitumour activity of oral E7080, a novel inhibitor of multiple tyrosine kinases, in human sarcoma xenografts by Bruheim, Skjalg, Kristian, Alexandr, Uenaka, Toshimitsu, Suo, Zhenhe, Tsuruoka, Akihiko, Nesland, Jahn M., Fodstad, Øystein

“…E7080 is an inhibitor of multiple tyrosine kinases, several of which have pro‐angiogenic properties, including receptors for VEGF, FGF, SCF and PDGF. We…”
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Differential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer xenograft by Skrbo, Nirma, Hjortland, Geir-Olav, Kristian, Alexandr, Holm, Ruth, Nord, Silje, Prasmickaite, Lina, Engebraaten, Olav, Mælandsmo, Gunhild M, Sørlie, Therese, Andersen, Kristin

“…Intratumor heterogeneity caused by genetic, phenotypic or functional differences between cancer cell subpopulations is a considerable clinical challenge…”
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Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma by Saelen, Marie Grøn, Ree, Anne Hansen, Kristian, Alexandr, Fleten, Karianne Giller, Furre, Torbjørn, Hektoen, Helga Helseth, Flatmark, Kjersti

“…The histone deacetylase inhibitor vorinostat is a candidate radiosensitizer in locally advanced rectal cancer (LARC). Radiosensitivity is critically influenced…”
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Exploring the peritoneal surface malignancy phenotype—a pilot immunohistochemical study of human pseudomyxoma peritonei and derived animal models by Flatmark, Kjersti, MD, PhD, Davidson, Ben, MD, PhD, Kristian, Alexandr, MSc, Stavnes, Helene Tuft, MSc, Førsund, Mette, MSc, Reed, Wenche, MD, PhD

“…Summary Peritoneal surface malignancies are characterized by the propensity for tumor growth on peritoneal surfaces without development of extraperitoneal…”
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Longitudinal Magnetic Resonance Imaging-Based Assessment of Vascular Changes and Radiation Response in Androgen-Sensitive Prostate Carcinoma Xenografts under Androgen-Exposed and Androgen-Deprived Conditions by Røe, Kathrine, Seierstad, Therese, Kristian, Alexandr, Mikalsen, Lars Tore Gyland, Mælandsmo, Gunhild Mari, van der Kogel, Albert J., Ree, Anne Hansen, Olsen, Dag Rune

“…Prostate cancer (PCa) patients receive androgen-deprivation therapy (ADT) to reduce tumor burden. However, complete eradication of PCa is unusual, and…”
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Validation and use of microdialysis for determination of pharmacokinetic properties of the chemotherapeutic agent mitomycin C - an experimental study by Sørensen, Olaf, Andersen, Anders, Olsen, Harald, Alexandr, Kristian, Ekstrøm, Per Olaf, Giercksky, Karl-Erik, Flatmark, Kjersti

“…Mitomycin C is a chemotherapeutic agent used in the treatment of peritoneal surface malignancies, administered as hyperthermic intraperitoneal chemotherapy…”
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Dynamic 18F-FDG PET for Assessment of Tumor Physiology in Two Breast Carcinoma Xenografts by Alexandr Kristian, Line B. Nilsen, Kathrine Roe, Mona-Elisabeth Revheim, Olav Engebråten, Gunhild M. Mælandsmo, Ruth Holm, Eirik Malinen, Therese Seierstad

“…Purpose To compare dynamic 2-deoxy-2-[18F]fluoro-Dglucose positron emission tomography (18F-FDG PET) parameters in two selected human breast cancer xenografts…”
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The SRC-family serves as a therapeutic target in triple negative breast cancer with acquired resistance to chemotherapy by Egeland, Eivind Valen, Seip, Kotryna, Skourti, Eleni, Øy, Geir Frode, Pettersen, Solveig J., Pandya, Abhilash D., Dahle, Maria A., Haugen, Mads H., Kristian, Alexander, Nakken, Sigve, Engebraaten, Olav, Mælandsmo, Gunhild M., Prasmickaite, Lina

“…Background Resistance to chemotherapy, combined with heterogeneity among resistant tumors, represents a significant challenge in the clinical management of…”
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Liver X receptors induce antiproliferative effects in basal-like breast cancer by Haugen, Mads, von der Lippe Gythfeldt, Hedda, Egeland, Eivind Valen, Svartdal Normann, Lisa, Pandya, Abhilash D, Vedin, Lise-Lotte, Juell, Siri, Tenstad, Ellen, Øy, Geir Frode, Kristian, Alexandr, Marangoni, Elisabetta, Sørlie, Therese, Steffensen, Knut Rune, Mælandsmo, Gunhild Mari, Engebråten, Olav

“…Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The…”
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Dynamic (18)F-FDG-PET for monitoring treatment effect following anti-angiogenic therapy in triple-negative breast cancer xenografts by Kristian, Alexandr, Revheim, Mona Elisabeth, Qu, Hong, Mælandsmo, Gunhild M, Engebråten, Olav, Seierstad, Therese, Malinen, Eirik

“…Dynamic (18)F-FDG PET allows the study of glucose distribution in tissues as a function of time and space. Using pharmacokinetics, the temporal uptake pattern…”
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Variability of dynamic 18F-FDG-PET data in breast cancer xenografts by Pitman, Kathinka E, Rusten, Espen, Kristian, Alexandr, Malinen, Eirik

“…A murine breast cancer xenograft model was employed to evaluate inter- and intra-variability of various parameters derived from dynamic positron emission…”
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Abstract 2053: Dynamic 18F-FDG PET parameters variation in patient-derived breast cancer xenograft and correlation with outcome following treatment with cytotoxic agents by Kristian, Alexandr, Revheim, Mona-Elizabeth, Qu, Hong, Mælandsmo, Gunhild, Engebraaten, Olav, Malinen, Eirik

“…Abstract Using pharmacokinetic modeling for dynamic 18FDG PET (D-PET) the temporal and spatial uptake pattern of 18FDG may be separated into components…”
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