Search Results - "Kristensen, Niels Rode"

Model Description Language (MDL): A Standard for Modeling and Simulation by Smith, Mike K., Moodie, Stuart L., Bizzotto, Roberto, Blaudez, Eric, Borella, Elisa, Carrara, Letizia, Chan, Phylinda, Chenel, Marylore, Comets, Emmanuelle, Gieschke, Ronald, Harling, Kajsa, Harnisch, Lutz, Hartung, Niklas, Hooker, Andrew C., Karlsson, Mats O., Kaye, Richard, Kloft, Charlotte, Kokash, Natallia, Lavielle, Marc, Lestini, Giulia, Magni, Paolo, Mari, Andrea, Mentré, France, Muselle, Chris, Nordgren, Rikard, Nyberg, Henrik B., Parra‐Guillén, Zinnia P., Pasotti, Lorenzo, Rode‐Kristensen, Niels, Sardu, Maria L., Smith, Gareth R., Swat, Maciej J., Terranova, Nadia, Yngman, Gunnar, Yvon, Florent, Holford, Nick

“…MOTIVATION Models are now used not just for data analysis, but for knowledge representation integrating across a wide range of data sources and model types…”
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Dose/exposure–response modeling in dose titration trials: Overcoming the titration paradox by Kristensen, Niels Rode, Agersø, Henrik

“…Response‐based dose individualization or dose titration is a powerful approach to achieve precision dosing. Yet, titration as an individualization strategy is…”
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Pharmacokinetic and pharmacodynamic properties of once‐weekly insulin icodec in individuals with type 1 diabetes by Hövelmann, Ulrike, Engberg, Susanne, Heise, Tim, Kristensen, Niels Rode, Nørgreen, Lea, Zijlstra, Eric, Ribel‐Madsen, Rasmus

“…Aims To investigate the pharmacokinetic/pharmacodynamic properties of once‐weekly insulin icodec in individuals with type 1 diabetes (T1D). Materials and…”
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Response to “mixed‐effects models and the drug titration paradox” by Kristensen, Niels Rode, Agersø, Henrik

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Molecular and pharmacological characterization of insulin icodec: a new basal insulin analog designed for once-weekly dosing by Nishimura, Erica, Pridal, Lone, Glendorf, Tine, Hansen, Bo Falk, Hubálek, František, Kjeldsen, Thomas, Kristensen, Niels Rode, Lützen, Anne, Lyby, Karsten, Madsen, Peter, Pedersen, Thomas Åskov, Ribel-Madsen, Rasmus, Stidsen, Carsten Enggaard, Haahr, Hanne

“…IntroductionInsulin icodec is a novel, long-acting insulin analog designed to cover basal insulin requirements with once-weekly subcutaneous administration…”
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Pharmacokinetic and Pharmacodynamic Characteristics of Insulin Icodec After Subcutaneous Administration in the Thigh, Abdomen or Upper Arm in Individuals with Type 2 Diabetes Mellitus by Plum-Mörschel, Leona, Andersen, Lizette Ravn, Hansen, Solvejg, Hövelmann, Ulrike, Krawietz, Patricia, Kristensen, Niels Rode, Lehrskov, Lars Lang, Haahr, Hanne

“…Background and Objective Individuals with diabetes mellitus may prefer different body regions for subcutaneous insulin administration. This trial investigated…”
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Considerations for Industry—Preparing for the FDA Model‐Informed Drug Development (MIDD) Paired Meeting Program by Galluppi, Gerald R., Ahamadi, Malidi, Bhattacharya, Souvik, Budha, Nageshwar, Gheyas, Ferdous, Li, Chi‐Chung, Chen, Yuan, Dosne, Anne‐Gaëlle, Kristensen, Niels Rode, Magee, Mindy, Samtani, Mahesh N., Sinha, Vikram, Taskar, Kunal, Upreti, Vijay V., Yang, Jianning, Cook, Jack

“…A recent industry perspective published in this journal describes the benefits received by drug companies from participation in the MIDD Pilot Program. Along…”
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Parameter estimation in stochastic grey-box models by Kristensen, Niels Rode, Madsen, Henrik, Jørgensen, Sten Bay

“…An efficient and flexible parameter estimation scheme for grey-box models in the sense of discretely, partially observed Itô stochastic differential equations…”
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Insulin degludec's ultra-long pharmacokinetic properties observed in adults are retained in children and adolescents with type 1 diabetes by Biester, Torben, Blaesig, Sarah, Remus, Kerstin, Aschemeier, Bärbel, Kordonouri, Olga, Granhall, Charlotte, Søndergaard, Flemming, Kristensen, Niels Rode, Haahr, Hanne, Danne, Thomas

“…Insulin degludec (IDeg) is a basal insulin with an ultra‐long pharmacokinetic profile in adults that at steady‐state produces remarkably flat and stable…”
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Population stochastic modelling (PSM)—An R package for mixed-effects models based on stochastic differential equations by Klim, Søren, Mortensen, Stig Bousgaard, Kristensen, Niels Rode, Overgaard, Rune Viig, Madsen, Henrik

“…Abstract The extension from ordinary to stochastic differential equations (SDEs) in pharmacokinetic and pharmacodynamic (PK/PD) modelling is an emerging field…”
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Clearance of rFVIIa and NN1731 after intravenous administration to Beagle dogs by Agersø, Henrik, Kristensen, Niels Rode, Østergaard, Henrik, Karpf, Ditte Maria, Hermit, Mette Brunsgaard, Pelzer, Hermann, Petersen, Lars Christian, Ezban, Mirella

“…NN1731 is a recombinant activated factor VII (rFVIIa) analogue with enhanced activity. The objective of the present study was to evaluate the clearance…”
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A method for systematic improvement of stochastic grey-box models by Kristensen, Niels Rode, Madsen, Henrik, Jørgensen, Sten Bay

“…A systematic framework for improving the quality of continuous time models of dynamic systems based on experimental data is presented. The framework is based…”
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Insulin degludec's ultra-long pharmacokinetic properties observed in adults are retained in children and adolescents with type 1 diabetes: Insulin degludec in children/adolescents by Biester, Torben, Blaesig, Sarah, Remus, Kerstin, Aschemeier, Bärbel, Kordonouri, Olga, Granhall, Charlotte, Søndergaard, Flemming, Kristensen, Niels Rode, Haahr, Hanne, Danne, Thomas

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Using stochastic differential equations for PK/PD model development by KRISTENSEN, Niels Rode, MADSEN, Henrik, INGWERSEN, Steen Hvass

“…A method for PK/PD model development based on stochastic differential equation models is proposed. The new method has a number of advantages compared to…”
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An investigation of some tools for process model indentification for prediction by Kristensen, Niels Rode, Madsen, Henrik, Jørgensen, Sten Bay

“…Process identification is undergoing tremendous developments as computing capabilities are increasing. These developments also lead to an increased demand for…”
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Computer aided continuous time stochastic process modelling by Kristensen, Niels Rode, Madsen, Henrik, Jørgensen, Sten Bay

“…This chapter discusses the grey-box approach to process modeling that combines deterministic and stochastic modeling for the identification of models for…”
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Developing phenomena models from experimental data by Kristensen, Niels Rode, Madsen, Henrik, Jørgensen, Sten Bay

“…A systematic approach for developing phenomena models from experimental data is presented. The approach is based on integrated application of stochastic…”
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A unified framework for systematic model improvement by Kristensen, Niels Rode, Madsen, Henrik, Bay Jørgensen, Sten

“…This chapter describes a unified framework for systematic model improvement. The framework is based on interplay between stochastic differential equation (SDE)…”
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Using continuous time stochastic modelling and nonparametric statistics to improve the quality of first principles models by Kristensen, Niels Rode, Madsen, Henrik, Jørgensen, Sten Bay

“…A methodology is presented that combines modelling based on first principles and data based modelling into a modelling cycle that facilitates fast…”
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