Search Results - "Krissansen, GW"

Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis by Kanwar, Jagat R., Kanwar, Rupinder K., Krissansen, Geoffrey W.

“…In multiple sclerosis, the immune system attacks the white matter of the brain and spinal cord, leading to disability and/or paralysis. Myelin,…”
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Mouse B7-H3 induces antitumor immunity by SUN, X, VALE, M, LEUNG, E, KANWAR, J. R, GUPTA, R, KRISSANSEN, G. W

“…Members of the B7 family costimulate the proliferation of lymphocytes during the initiation and maintenance of antigen-specific humoral and cell-mediated…”
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Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotherapy by SUN, X, KANWAR, J. R, LEUNG, E, LEHNERT, K, WANG, D, KRISSANSEN, G. W

“…Solid tumors meet their demands for nascent blood vessels and increased glycolysis, to combat hypoxia, by activating multiple genes involved in angiogenesis…”
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Effects of Survivin Antagonists on Growth of Established Tumors and B7-1 Immunogene Therapy by Kanwar, Jagat R., Shen, Wei-Ping, Kanwar, Rupinder K., Berg, Randal W., Krissansen, Geoffrey W.

“…Background: Survivin, a member of the inhibitor of apoptosis (IAP) protein family, is detectable in most types of cancer, and its presence is associated with a…”
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Arsenic trioxide synergizes with B7H3‐mediated immunotherapy to eradicate hepatocellular carcinomas by Luo, Liqiong, Qiao, Haiquan, Meng, Fanqiang, Dong, Xuesong, Zhou, Baoguo, Jiang, Hongchi, Kanwar, Jagat R, Krissansen, Geoffrey W, Sun, Xueying

“…Arsenic trioxide (As2O3), a valuable anticancer drug for the treatment of acute promyelocytic leukemia, may also have therapeutic potential for the treatment…”
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Polymorphisms in the organic cation transporter genes SLC22A4 and SLC22A5 and Crohn's disease in a New Zealand Caucasian cohort by Leung, Euphemia, Hong, Jiwon, Fraser, Alan G, Merriman, Tony R, Vishnu, Prakash, Krissansen, Geoffrey W

“…Polymorphisms in the organic cation transporter (OCTN) genes SLC22A4 (OCTN1; polymorphism 1672C/T) and SLC22A5 (OCTN2; polymorphism −207G/C) at the…”
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Overexpression of von Hippel-Lindau tumor suppressor protein and antisense HIF-1α eradicates gliomas by Sun, X, Liu, M, Wei, Y, Liu, F, Zhi, X, Xu, R, Krissansen, G W

“…The von Hippel–Lindau tumor suppressor protein (pVHL) suppresses tumor formation by binding the α subunits of hypoxia-inducible-factors responsible for…”
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beta 7 Integrins contribute to demyelinating disease of the central nervous system by Kanwar, J R, Harrison, JEB, Wang, D, Leung, E, Mueller, W, Wagner, N, Krissansen, G W

“…A role for alpha 4 integrins in different forms of the multiple sclerosis-like disease experimental autoimmune encephalomyelitis (EAE) has been demonstrated,…”
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Temporal Expression of Heat Shock Proteins 60 and 70 at Lesion-Prone Sites During Atherogenesis in ApoE-Deficient Mice by Kanwar, Rupinder K, Kanwar, Jagat R, Wang, Dongmao, Ormrod, Douglas J, Krissansen, Geoffrey W

“…In the study, we investigate whether the expressions of heat shock protein (hsp)60 (a potential autoantigen) and the stress-inducible form of cytoprotector…”
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Long-term expression of angiostatin suppresses metastatic liver cancer in mice by Xu, Ruian, Sun, Xueying, Tse, Lai-Yin, Li, Hua, Chan, Pui-Chung, Xu, Sue, Xiao, Weidong, Kung, Hsiang-Fu, Krissansen, Geoffrey W., Fan, Sheung-Tat

“…Metastatic liver cancer has a very poor prognosis and lacks effective therapy. Anti-angiogenic therapies, which starve tumors of blood supply, have proven to…”
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Regression of solid tumors by engineered overexpression of von Hippel-Lindau tumor suppressor protein and antisense hypoxia-inducible factor-1α by SUN, X, KANWAR, J. R, LEUNG, E, VALE, M, KRISSANSEN, G. W

“…The von Hippel–Lindau tumor suppressor protein (pVHL) suppresses tumor formation by binding the α subunits of hypoxia-inducible factors (HIFs) responsible for…”
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Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci by KANWAR, Jagat R, KANWAR, Rupinder K, PANDEY, Sushil, CHING, Lai-Ming, KRISSANSEN, Geoffrey W

“…The promise of cancer immunotherapy is that it will not only eradicate primary tumors but will generate systemic antitumor immunity capable of destroying…”
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Prevention of a chronic progressive form of experimental autoimmune encephalomyelitis by an antibody against mucosal addressin cell adhesion molecule-1, given early in the course of disease progression by Kanwar, Jagat R, Kanwar, Rupinder K, Wang, Dongmao, Krissansen, Geoffrey W

“…A role for α4 and β7 integrins in mediating leucocyte entry into the central nervous system in the multiple sclerosis (MS)‐like disease experimental autoimmune…”
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The beta 7 integrin gene (Itgb-7) promoter is responsive to TGF- beta 1: defining control regions by Lim, Siew Pheng, Leung, E, Krissansen, G W

“…The beta 7 integrins LPAM-1 ( alpha 4 beta 7) and M290 ( alpha E beta 7) mediate the homing of lymphocytes to gut-associated lymphoid tissue, and the proposed…”
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Polymorphisms of CARD15/NOD2 and CD14 genes in New Zealand Crohn's disease patients by Leung, Euphemia, Hong, Jiwon, Fraser, Alan G, Merriman, Tony R, Vishnu, Prakash, Abbott, William GH, Krissansen, Geoffrey W

“…Polymorphisms in the CARD15/NOD2 gene, which encodes a cytosolic protein involved in bacterial recognition, are associated with development of Crohn's disease…”
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Anti‐angiogenic therapy subsequent to adeno‐associated‐virus‐mediated immunotherapy eradicates lymphomas that disseminate to the liver by Sun, Xueying, Krissansen, Geoffrey W., Fung, Peter W.C., Xu, Sue, Shi, Juan, Man, Kwan, Fan, Sheung‐tat, Xu, Ruian

“…Liver cancer has a very poor prognosis and lacks effective therapy. We have previously demonstrated that intraportal injection of adeno‐associated‐viral (AAV)…”
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Intramuscular delivery of antiangiogenic genes suppresses secondary metastases after removal of primary tumors by Sun, Xueying, Qiao, Haiquan, Jiang, Hongchi, Zhi, Xuting, Liu, Fengjun, Wang, Jianli, Liu, Meng, Dong, Dianning, Kanwar, Jagat R, Xu, Ruian, Krissansen, Geoffrey W

“…The success of surgery to remove primary tumors can be compromised by the subsequent outgrowth of metastases. It is recognized that primary tumors secrete…”
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Bioassay detects soluble MAdCAM-1 in body fluids by Leung, Euphemia, Lehnert, Klaus B, Kanwar, Jagat R, Yang, Yi, Mon, Yu, McNeil, H Patrick, Krissansen, Geoffrey W

“…Mucosal addressin cell adhesion molecule (MAdCAM‐1) is a key player in mediating the infiltration of leucocytes into chronically inflamed tissues. Five…”
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Angiostatin enhances B7.1-mediated cancer immunotherapy independently of effects on vascular endothelial growth factor expression by Sun, X, Kanwar, J R, Leung, E, Lehnert, K, Wang, D, Krissansen, G W

“…Tumors must develop an adequate vascular network to meet their increasing demands for nutrition and oxygen. Angiostatin, a multiple kringle (1-4)-containing…”
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Mucosal vascular addressin cell adhesion molecule-1 is expressed outside the endothelial lineage on fibroblasts and melanoma cells by Leung, Euphemia, Kanwar, Rupinder K, Kanwar, Jagat R, Krissansen, Geoffrey W

“…Mucosal vascular addressin cell adhesion molecule‐1 (MAdCAM‐1) is predominantly expressed on high endothelial venules in inflamed tissues where it assists with…”
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