Search Results - "Krisky, David"

Gene therapy for pain: Results of a phase I clinical trial by Fink, David J., Wechuck, James, Mata, Marina, Glorioso, Joseph C., Goss, James, Krisky, David, Wolfe, Darren

“…Objective: Preclinical evidence indicates that gene transfer to the dorsal root ganglion using replication‐defective herpes simplex virus (HSV)‐based vectors…”
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1348 Development of enLIGHTEN™ Alpha-201 herpes simplex viral vectors encoding payloads targeting the tumor microenvironment by Diers, Anne R, Guo, Qiuchen, Christie, John D, Krisky, David, Bouch, Karen, Tak, Paul P, Barone, Francesca

“…BackgroundFailure to respond to conventional immunotherapies arises from heterogeneous mechanisms present in the tumor microenvironments (TME) that drive…”
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1096 A novel viral immunotherapeutic targeting the CD47/SIRPα axis demonstrates potent anti-tumor effects by Diers, Anne R, Guo, Qiuchen, Christie, John D, Krisky, David, Tak, Paul P, Barone, Francesca

“…BackgroundThe CD47/SIRPα axis mediates a ‘don’t eat me’ signal exploited by tumor cells to escape macrophage-mediated immune surveillance. Anti-CD47 therapies…”
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Effects of herpes simplex virus vector-mediated enkephalin gene therapy on bladder overactivity and nociception by Yokoyama, Hitoshi, Oguchi, Tomohiko, Goins, William F, Goss, James R, Nishizawa, Osamu, de Groat, William C, Wolfe, Darren, Krisky, David M, Glorioso, Joseph C, Yoshimura, Naoki

“…We previously reported the effects of herpes simplex virus (HSV) vector-mediated enkephalin on bladder overactivity and pain. In this study, we evaluated the…”
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HSV Delivery of a Ligand-regulated Endogenous Ion Channel Gene to Sensory Neurons Results in Pain Control Following Channel Activation by Goss, James R, Cascio, Michael, Goins, William F, Huang, Shaohua, Krisky, David M, Clarke, Richard J, Johnson, Jon W, Yokoyama, Hitoshi, Yoshimura, Naoki, Gold, Michael S, Glorioso, Joseph C

“…Persistent pain remains a tremendous health problem due to both its prevalence and dearth of effective therapeutic interventions. To maximize pain relief while…”
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Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth by Li, Han, Baskaran, Rajasekaran, Krisky, David M, Bein, Kiflai, Grandi, Paola, Cohen, Justus B, Glorioso, Joseph C

“…Abstract ICP0 is a multi-functional herpes simplex virus type 1 (HSV-1) immediate-early (IE) gene product that contributes to efficient virus growth and…”
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A Clinical Trial of Gene Therapy for Chronic Pain by Wolfe, Darren, Wechuck, James, Krisky, David, Mata, Marina, Fink, David J.

“…ABSTRACT The first human trial of gene therapy for chronic pain, a phase 1 study of a nonreplicating herpes simplex virus (HSV)‐based vector engineered to…”
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395 Detection of viral antigen and immune activation after intra-tumor injection of CAN-3110 (ICP-34.5 expressing HSV-1 oncolytic virus) in patients with recurrent high-grade glioma by Barone, Francesca, Lawler, Sean, Aguilar, Laura, Dwyer, Jessica, Guzik, Brian, Soloman, Isaac, Nakashima, Hiroshi, Triggs, Daniel, Zhang, Abigail Tianai, Zeng, Yu, Woods, Jared, Grant, James, Reardon, David, Wen, Patrick, Lee, Eudocia Quant, Ligon, Keith, Pisano, William, Rodig, Scott, Suva, Mario, Wucherpfennig, Kai, Marx, Sascha, Gritsch, Simon, Mathewson, Nathan, Severgnini, Mariano, Giobbie-Hurder, Anita, Krisky, David, Aguilar-Cordova, Estuardo, Tak, Paul, Antonio Chiocca, E

“…BackgroundRecurrent high-grade glioma (HGG) represents a significant clinical unmet need with expected survival between 6 to 9 months. Oncolytic viruses are a…”
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Engineering cell lines for production of replication defective HSV-1 gene therapy vectors by Grant, Kyle G, Krisky, David M, Ataai, Mohammed M, Glorioso, Joseph C. III

“…Herpes simplex virus type 1 (HSV-1) represents an attractive vehicle for a variety of gene therapy applications. To render this virus safe for clinical use,…”
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Herpes Simplex Virus‐Mediated Expression of Pax3 and MyoD in Embryoid Bodies Results in Lineage‐Related Alterations in Gene Expression Profiles by Craft, April M., Krisky, David M., Wechuck, James B., Lobenhofer, Edward K., Jiang, Ying, Wolfe, Darren P., Glorioso, Joseph C.

“…The ability of embryonic stem cells to develop into multiple cell lineages provides a powerful resource for tissue repair and regeneration. Gene transfer…”
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Construction and production of recombinant herpes simplex virus vectors by Goins, William F, Krisky, David M, Wechuck, James B, Huang, Shaohua, Glorioso, Joseph C

“…Virus vectors have been employed as gene transfer vehicles for various pre-clinical and clinical gene therapy applications. Replication-competent herpes…”
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Immobilized Cobalt Affinity Chromatography Provides a Novel, Efficient Method for Herpes Simplex Virus Type 1 Gene Vector Purification by CANPING JIANG, WECHUCK, James B, GOINS, William F, KRISKY, David M, WOLFE, Darren, ATAAI, Mohammad M, GLORIOSO, Joseph C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An HSV vector system for selection of ligand-gated ion channel modulators by Glorioso, Joseph C, Srinivasan, Rahul, Huang, Shaohua, Chaudhry, Suchita, Sculptoreanu, Adrian, Krisky, David, Cascio, Michael, Friedman, Peter A, de Groat, William C, Wolfe, Darren

“…Pathological alterations of ion channel activity result from changes in modulatory mechanisms governing receptor biology. Here we describe a conditional herpes…”
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Delivery using herpes simplex virus: an overview by Goins, William F, Wolfe, Darren, Krisky, David M, Bai, Qing, Burton, Ed A, Fink, David J, Glorioso, Joseph C

“…The human herpesviruses represent excellent candidate viruses for several types of gene vector applications. As a class, they are large DNA viruses with the…”
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Generation of replication-competent and -defective HSV vectors by Goins, William F, Krisky, David M, Wechuck, James B, Wolfe, Darren, Huang, Shaohua, Glorioso, Joseph C

“…Engineering effective vectors has been crucial to the efficient delivery and expression of therapeutic gene products in vivo. Among these, HSV-1 represents an…”
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Treatment of rat gliosarcoma brain tumors by HSV-based multigene therapy combined with radiosurgery by Niranjan, Ajay, Wolfe, Darren, Tamura, Masakazu, Karina Soares, M, Krisky, David M, Dade Lunsford, L, Li, Songhui, Fellows-Mayle, Wendy, DeLuca, Neal A, Cohen, Justus B, Glorioso, Joseph C

“…Our laboratory has employed replication-defective herpes simplex virus type 1 gene transfer vectors for treatment of animal models of human malignant…”
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Inactivation of herpes simplex type 1 gene vector on immobilized metal affinity chromatography: Oxidative damage by hydroxyl free radicals and its prevention by Jiang, Canping, Ataai, Mohammad, Ozuer, Ali, Krisky, David, Wechuck, James, Pornsuwan, Soraya, Pourarian, Fazard, Glorioso, Joseph C.

“…Metal catalyzed oxidation (MCO), which typically involves oxygen free radical generation, is an important pathway that leads to the deterioration of many…”
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1110. Engineering Cell Lines for the Production of Highly Replication Defective HSV-1 Vectors by Grant, Kyle G., Krisky, David M., Ataai, Mohammed M., Glorioso, Joseph C.

“…In order to mass produce clinical grade highly replication defective HSV-1 vectors, efficient cell lines must be generated to complement missing viral…”
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Connexin 43-Enhanced Suicide Gene Therapy Using Herpesviral Vectors by Marconi, Peggy, Tamura, Masakazu, Moriuchi, Shusuke, Krisky, David M., Niranjan, Ajay, Goins, William F., Cohen, Justus B., Glorioso, Joseph C.

“…Tumor cell transduction with the herpes simplex virus (HSV) thymidine kinase (tk) gene and treatment with ganciclovir (GCV) is a widely studied cancer gene…”
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235. Herpes Simplex Virus Vector Mediated Heme Oxygenase Gene Therapy of Heart Ischemia-Reperfusion by Goins, William F., Frampton, Arthur R., Nakao, Atsunori, Tomiyama, Koji, Clawson, David S., Wechuck, James, Huang, Shao-hua, Krisky, David M., Cohen, Justus B., Murase, Noriko, Glorioso, Joseph C.

“…Heart transplantation is the preferred therapy for patients with a variety of end-stage heart diseases. Developments in the use of potent immunosuppressive…”
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