Search Results - "Krishnan, Sowmya"

De novo design of new chemical entities for SARS-CoV-2 using artificial intelligence by Bung, Navneet, Krishnan, Sowmya R, Bulusu, Gopalakrishnan, Roy, Arijit

“…The novel coronavirus SARS-CoV-2 has severely affected the health and economy of several countries. Multiple studies are in progress to design novel…”
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R-SIM: A Database of Binding Affinities for RNA-small Molecule Interactions by Ramaswamy Krishnan, Sowmya, Roy, Arijit, Michael Gromiha, M.

“…[Display omitted] •Collated the experimental binding affinity data for 2501 RNA-small molecule interactions from literature and existing databases involving,…”
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Reliable method for predicting the binding affinity of RNA-small molecule interactions using machine learning by Krishnan, Sowmya R, Roy, Arijit, Gromiha, M Michael

“…Abstract Ribonucleic acids (RNAs) play important roles in cellular regulation. Consequently, dysregulation of both coding and non-coding RNAs has been…”
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Mechanism of drug resistance in HIV-1 protease subtype C in the presence of Atazanavir by Sankaran, S.V., Krishnan, Sowmya R., Sayed, Yasien, Gromiha, M. Michael

“…AIDS is one of the deadliest diseases in the history of humankind caused by HIV. Despite the technological development, curtailing the viral infection inside…”
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Understanding Drug Resistance of Wild-Type and L38HL Insertion Mutant of HIV-1 C Protease to Saquinavir by Venkatachalam, Sankaran, Murlidharan, Nisha, Krishnan, Sowmya R, Ramakrishnan, C, Setshedi, Mpho, Pandian, Ramesh, Barh, Debmalya, Tiwari, Sandeep, Azevedo, Vasco, Sayed, Yasien, Gromiha, M Michael

“…Acquired immunodeficiency syndrome (AIDS) is one of the most challenging infectious diseases to treat on a global scale. Understanding the mechanisms…”
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Pediatric Endocrinology Milestones 2.0-guide to their implementation by Tillotson, Cara V, Becetti, Imen, Hwu, Katherine, Page, Laura, Krishnan, Sowmya, Stafford, Dianne, Stanley, Takara, Vuguin, Patricia, Barker, Jennifer M

“…The Milestones were initiated by the Accreditation Council for Graduate Medical Education (ACGME) to provide a framework for monitoring a trainee's progression…”
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SARS‐CoV‐2 infection and paediatric endocrine disorders: Risks and management considerations by Miller, Ryan, Ashraf, Ambika P., Gourgari, Evgenia, Gupta, Anshu, Kamboj, Manmohan K., Kohn, Brenda, Lahoti, Amit, Mak, Daniel, Mehta, Shilpa, Mitchell, Deborah, Patel, Neha, Raman, Vandana, Reynolds, Danielle G., Yu, Christine, Krishnan, Sowmya

“…Background Coronavirus‐19 (COVID‐19) is a disease caused by the SARS‐CoV‐2 virus, the seventh coronavirus identified as causing disease in humans. The…”
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Lipoprotein abnormalities in compound heterozygous lipoprotein lipase deficiency after treatment with a low-fat diet and orlistat by Blackett, Piers, MB, ChB, FNLA, Tryggestad, Jeanie, MD, Krishnan, Sowmya, MD, Li, Shibo, PhD, Xu, Weihong, PhD, Alaupovic, Petar, PhD, Quiroga, Carmen, Copeland, Kenneth, MD

“…Background The treatment of familial hyperchylomicronemia presenting in early childhood with episodes of pancreatitis has been ineffective, and affected…”
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Management Challenges in a Child with Chronic Hyponatremia: Use of V2 Receptor Antagonist by McNall-Knapp, Rene Y., Lane, Pascale, Divya, Gunda, Mallappa, Ashwini, Deshpande, Swapna, Krishnan, Sowmya, Vishwanath, Anu

“…Chronic hyponatremia is very rare in children and is often seen in the setting of congestive heart failure or liver failure in adults. Here, we report an…”
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Corrigendum to “Management Challenges in a Child with Chronic Hyponatremia: Use of V2 Receptor Antagonist” by McNall-Knapp, Rene Y., Lane, Pascale, Divya, Gunda, Mallappa, Ashwini, Deshpande, Swapna, Krishnan, Sowmya, Vishwanath, Anu

“…In the article titled “Management Challenges in a Child with Chronic Hyponatremia: Use of V2 Receptor Antagonist” [1], the name of the fourth author was…”
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Sex differences in body composition early in life by Fields, David A., PhD, Krishnan, Sowmya, MD, Wisniewski, Amy B., PhD

“…Abstract Background: Early development of the percentage of fat and muscle is rarely considered, but is important because excessive fat is related to the…”
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Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes by Al-Sabri, Mohamed H, Behare, Neha, Alsehli, Ahmed M, Berkins, Samuel, Arora, Aadeya, Antoniou, Eirini, Moysiadou, Eleni I, Anantha-Krishnan, Sowmya, Cosmen, Patricia D, Vikner, Johanna, Moulin, Thiago C, Ammar, Nourhene, Boukhatmi, Hadi, Clemensson, Laura E, Rask-Andersen, Mathias, Mwinyi, Jessica, Williams, Michael J, Fredriksson, Robert, Schiöth, Helgi B

“…The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this study, we employ to dissect possible underlying mechanisms for SIM. We…”
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Accelerating De Novo Drug Design against Novel Proteins Using Deep Learning by Krishnan, Sowmya Ramaswamy, Bung, Navneet, Bulusu, Gopalakrishnan, Roy, Arijit

“…In the world plagued by the emergence of new diseases, it is essential that we accelerate the drug design process to develop new therapeutics against them. In…”
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An In Silico Explainable Multiparameter Optimization Approach for De Novo Drug Design against Proteins from the Central Nervous System by Bung, Navneet, Krishnan, Sowmya Ramaswamy, Roy, Arijit

“…The aim of drug design and development is to produce a drug that can inhibit the target protein and possess a balanced physicochemical and toxicity profile…”
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De Novo Structure-Based Drug Design Using Deep Learning by Krishnan, Sowmya Ramaswamy, Bung, Navneet, Vangala, Sarveswara Rao, Srinivasan, Rajgopal, Bulusu, Gopalakrishnan, Roy, Arijit

“…In recent years, deep learning-based methods have emerged as promising tools for de novo drug design. Most of these methods are ligand-based, where an initial…”
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Sex Differences in Cardiovascular Disease Risk in Adolescents With Type 1 Diabetes by Krishnan, Sowmya, MD, Fields, David A., PhD, Copeland, Kenneth C., MD, Blackett, Piers R., MD, Anderson, Michael P., PhD, Gardner, Andrew W., PhD

“…Abstract Background Cardiovascular disease is seen at a younger age and at a higher prevalence in patients with type 1 diabetes than in the general population…”
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Target-specific novel molecules with their recipe: Incorporating synthesizability in the design process by Krishnan, Sowmya Ramaswamy, Bung, Navneet, Srinivasan, Rajgopal, Roy, Arijit

“…Application of Artificial intelligence (AI) in drug discovery has led to several success stories in recent times. While traditional methods mostly relied upon…”
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162. Hungry Hungry Bones: Electrolyte Abnormalities in the Presence of Severe Malnutrition by Khoury, Molly N., Middleman, Amy B., Krishnan, Sowmya

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pBRICS: A Novel Fragmentation Method for Explainable Property Prediction of Drug-Like Small Molecules by Vangala, Sarveswara Rao, Krishnan, Sowmya Ramaswamy, Bung, Navneet, Srinivasan, Rajgopal, Roy, Arijit

“…Generative artificial intelligence algorithms have shown to be successful in exploring large chemical spaces and designing novel and diverse molecules. There…”
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An interpretable machine learning model for selectivity of small-molecules against homologous protein family by Vangala, Sarveswara Rao, Bung, Navneet, Krishnan, Sowmya Ramaswamy, Roy, Arijit

“…In the early stages of drug discovery, various experimental and computational methods are used to measure the specificity of small molecules against a target…”
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