Search Results - "Krishnan, Shanmugarajan"

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas by Amoozgar, Zohreh, Kloepper, Jonas, Ren, Jun, Tay, Rong En, Kazer, Samuel W., Kiner, Evgeny, Krishnan, Shanmugarajan, Posada, Jessica M., Ghosh, Mitrajit, Mamessier, Emilie, Wong, Christina, Ferraro, Gino B., Batista, Ana, Wang, Nancy, Badeaux, Mark, Roberge, Sylvie, Xu, Lei, Huang, Peigen, Shalek, Alex K., Fukumura, Dai, Kim, Hye-Jung, Jain, Rakesh K.

“…Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials. Here, we show that regulatory T (Treg) cells play a key role in GBM…”
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Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium by Seano, Giorgio, Nia, Hadi T., Emblem, Kyrre E., Datta, Meenal, Ren, Jun, Krishnan, Shanmugarajan, Kloepper, Jonas, Pinho, Marco C., Ho, William W., Ghosh, Mitrajit, Askoxylakis, Vasileios, Ferraro, Gino B., Riedemann, Lars, Gerstner, Elizabeth R., Batchelor, Tracy T., Wen, Patrick Y., Lin, Nancy U., Grodzinsky, Alan J., Fukumura, Dai, Huang, Peigen, Baish, James W., Padera, Timothy P., Munn, Lance L., Jain, Rakesh K.

“…The compression of brain tissue by a tumour mass is believed to be a major cause of the clinical symptoms seen in patients with brain cancer. However, the…”
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Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model by Iorgulescu, J Bryan, Ruthen, Neil, Ahn, Ryuhjin, Panagioti, Eleni, Gokhale, Prafulla C, Neagu, Martha, Speranza, Maria C, Eschle, Benjamin K, Soroko, Kara M, Piranlioglu, Raziye, Datta, Meenal, Krishnan, Shanmugarajan, Yates, Kathleen B, Baker, Gregory J, Jain, Rakesh K, Suvà, Mario L, Neuberg, Donna, White, Forest M, Chiocca, E Antonio, Freeman, Gordon J, Sharpe, Arlene H, Wu, Catherine J, Reardon, David A

“…The GL261 and CT2A syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM) but demonstrate distinct…”
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897-F Wnt inhibition improves efficacy of immune checkpoint blockade in glioblastoma by Krishnan, Shanmugarajan, Lee, Somin, Amoozgar, Zohreh, Subudhi, Sonu, Kumar, Ashwin Srinivasan, Posada, Jessica, Lindeman, Neal I, Lei, Pinji, Duquette, Mark, Roberge, Sylvie, Huang, Peigen, Andersson, Patrik, Datta, Meenal, Munn, Lance L, Fukumura, Dai, Jain, Rakesh K

“…BackgroundGlioblastoma (GBM) is a fatal malignancy with a median overall survival of <2 years with the current standard of care.1 Wnt signaling fuels GBM…”
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Implications of a granulocyte‐high glioblastoma microenvironment in immune suppression and therapy resistance by Krishnan, Shanmugarajan, Amoozgar, Zohreh, Fukumura, Dai, Jain, Rakesh K

“…The failure of anti‐VEGF/R and immune checkpoint therapies to improve overall survival in Phase III clinical trials in glioblastoma (GBM) is considered to be…”
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A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment by Griveau, Amelie, Seano, Giorgio, Shelton, Samuel J., Kupp, Robert, Jahangiri, Arman, Obernier, Kirsten, Krishnan, Shanmugarajan, Lindberg, Olle R., Yuen, Tracy J., Tien, An-Chi, Sabo, Jennifer K., Wang, Nancy, Chen, Ivy, Kloepper, Jonas, Larrouquere, Louis, Ghosh, Mitrajit, Tirosh, Itay, Huillard, Emmanuelle, Alvarez-Buylla, Arturo, Oldham, Michael C., Persson, Anders I., Weiss, William A., Batchelor, Tracy T., Stemmer-Rachamimov, Anat, Suvà, Mario L., Phillips, Joanna J., Aghi, Manish K., Mehta, Shwetal, Jain, Rakesh K., Rowitch, David H.

“…Gliomas comprise heterogeneous malignant glial and stromal cells. While blood vessel co-option is a potential mechanism to escape anti-angiogenic therapy, the…”
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Modulation of cerebral endothelial cell function by TGF-β in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition by Krishnan, Shanmugarajan, Szabo, Emese, Burghardt, Isabel, Frei, Karl, Tabatabai, Ghazaleh, Weller, Michael

“…Glioblastoma are among the most angiogenic tumors. The molecular mechanisms that control blood vessel formation by endothelial cells (EC) in glioblastoma…”
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Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models by Datta, Meenal, Chatterjee, Sampurna, Perez, Elizabeth M, Gritsch, Simon, Roberge, Sylvie, Duquette, Mark, Chen, Ivy X, Naxerova, Kamila, Kumar, Ashwin S, Ghosh, Mitrajit, Emblem, Kyrre E, Ng, Mei R, Ho, William W, Kumar, Pragya, Krishnan, Shanmugarajan, Dong, Xinyue, Speranza, Maria C, Neagu, Martha R, Iorgulescu, J Bryan, Huang, Raymond Y, Youssef, Gilbert, Reardon, David A, Sharpe, Arlene H, Freeman, Gordon J, Suvà, Mario L, Xu, Lei, Jain, Rakesh K

“…Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we found that ICBs induce cerebral edema in some patients and mice…”
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Thymosin beta 4 gene silencing decreases stemness and invasiveness in glioblastoma by WIRSCHING, Hans-Georg, KRISHNAN, Shanmugarajan, FLOREA, Ana-Maria, FREI, Karl, KRAYENBÜHL, Niklaus, HASENBACH, Kathy, REIFENBERGER, Guido, WELLER, Michael, TABATABAI, Ghazaleh

“…Thymosin beta 4 is a pleiotropic actin-sequestering polypeptide that is involved in wound healing and developmental processes. Thymosin beta 4 gene silencing…”
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A homing system targets therapeutic T cells to brain cancer by Samaha, Heba, Pignata, Antonella, Fousek, Kristen, Ren, Jun, Lam, Fong W., Stossi, Fabio, Dubrulle, Julien, Salsman, Vita S., Krishnan, Shanmugarajan, Hong, Sung-Ha, Baker, Matthew L., Shree, Ankita, Gad, Ahmed Z., Shum, Thomas, Fukumura, Dai, Byrd, Tiara T., Mukherjee, Malini, Marrelli, Sean P., Orange, Jordan S., Joseph, Sujith K., Sorensen, Poul H., Taylor, Michael D., Hegde, Meenakshi, Mamonkin, Maksim, Jain, Rakesh K., El-Naggar, Shahenda, Ahmed, Nabil

“…Successful T cell immunotherapy for brain cancer requires that the T cells can access tumour tissues, but this has been difficult to achieve. Here we show…”
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TMIC-61. LOSARTAN PREVENTS IMMUNOTHERAPY-ASSOCIATED EDEMA AND ENHANCES SURVIVAL IN GLIOBLASTOMA by Datta, Meenal, Chatterjee, Sampurna, Perez, Elizabeth, Gritsch, Simon, Roberge, Sylvie, Duquette, Mark, Chen, Ivy, Naxerova, Kamila, Kumar, Ashwin, Ghosh, Mitrajit, Emblem, Kyrre, Ng, Rosa, Ho, William, Kumar, Pragya, Krishnan, Shanmugarajan, Dong, Xinyue, Speranza, Maria, Neagu, Martha, Reardon, David A, Sharpe, Arlene, Freeman, Gordon, Suva, Mario, Xu, Lei, Jain, Rakesh

“…Abstract Immune checkpoint blockers (ICBs) have revolutionized the treatment of some solid cancers but have failed to benefit the majority of glioblastoma…”
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Abstract 1331: MiNK-215, an IL-15 armored FAP-targeting CAR iNKT cell therapy, effectively treats human organoid models of treatment-refractory MSS colorectal cancer (CRC) liver metastases by Krishnan, Shanmugarajan, Joshi, Bishnu, Keith, Justin, Frazier, Ryan, Kalinowska, Barbara, Choi, Jin San, Sanders, Stephanie, Boi, Shannon, Tonqueze, Olivier Le, Kushner, Nick, Soh, Kah Teong, Stein, Robert, Curiel, Tyler J., van Dijk, Marc A., Kim, Enoch, Chantzoura, Eleni, Rudqvist, Nils-Petter, Chand, Dhan

“…Abstract The presence of liver metastases in patients with microsatellite-stable (MSS) or mismatch repair proficient (pMMR) colorectal cancer (CRC) is…”
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Abstract 203: Inhibiting invasion and stemness in glioblastoma by thymosin beta 4 gene silencing: a new therapeutic target by Wirsching, Hans-Georg, Krishnan, Shanmugarajan, Florea, Ana-Maria, Frei, Karl, Krayenbühl, Niklaus, Hasenbach, Kathy, Reifenberger, Guido, Weller, Michael, Tabatabai, Ghazaleh

“…Abstract Glioblastoma are incurable primary brain tumors with one of the worst 5-year survival rate among all cancers. Despite multimodality treatment…”
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Retraction Note: A homing system targets therapeutic T cells to brain cancer by Samaha, Heba, Pignata, Antonella, Fousek, Kristen, Ren, Jun, Lam, Fong W., Stossi, Fabio, Dubrulle, Julien, Salsman, Vita S., Krishnan, Shanmugarajan, Hong, Sung-Ha, Baker, Matthew L., Shree, Ankita, Gad, Ahmed Z., Shum, Thomas, Fukumura, Dai, Byrd, Tiara T., Mukherjee, Malini, Marrelli, Sean P., Orange, Jordan S., Joseph, Sujith K., Sorensen, Poul H., Taylor, Michael D., Hegde, Meenakshi, Mamonkin, Maksim, Jain, Rakesh K., El-Naggar, Shahenda, Ahmed, Nabil

“…This Article has been retracted; see accompanying Retraction…”
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Abstract 2990: Antigen presentation deficiency and mesenchymal differentiation underlie resistance to immunotherapy in the murine syngeneic CT2A tumor model by Iorgulescu, Bryan, Ruthen, Neil, Ahn, Ryuhjin, Panagioti, Eleni, Gokhale, Prafulla, Neagu, Martha, Speranza, Maria, Eschle, Benjamin, Soroko, Kara, Piranlioglu, Raziye, Datta, Meenal, Krishnan, Shanmugarajan, Yates, Kathleen, Baker, Gregory, Jain, Rakesh, Suva, Mario, Neuberg, Donna, White, Forest, Chiocca, E., Freeman, Gordon, Sharpe, Arlene, Wu, Catherine, Reardon, David

“…Abstract The GL261-luc2 and CT2A-luc syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM), but…”
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Effect of silencing thymosin beta 4 gene expression on stemness and invasiveness in glioblastoma by Tabatabai, Ghazaleh, Krishnan, Shanmugarajan, Florea, Ana-Maria, Frei, Karl, Hasenbach, Kathy, Reifenberger, Guido, Krayenbuehl, Niklaus, Weller, Michael, Wirsching, Hans-Georg

“…Abstract only 2081 Background: Thymosin β4 (TB4) is a pleiotropic actin-sequestering polypeptide that is involved in wound healing and developmental processes…”
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Pharmacological evaluation of methanolic leaf extract of Swietenia mahagoni on acrylamide-induced neuropathic pain in rats by Vanitha, Subburaj, Thiagarajan, Venkata Rathina Kumar, Muthuraman, Arunachalam, Krishnan, Shanmugarajan, Aruna, Ajithadas, Tharabai, R

“…The present study was designed to investigate the antinociceptive effects of methanolic leaf extract of Swietenia mahagoni (MESM) on acrylamide-induced painful…”
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Novel progranulin mutations with reduced serum-progranulin levels in frontotemporal lobar degeneration by Chiang, Huei-Hsin, Forsell, Charlotte, Lilius, Lena, Öijerstedt, Linn, Thordardottir, Steinunn, Shanmugarajan, Krishnan, Westerlund, Marie, Nennesmo, Inger, Thonberg, Håkan, Graff, Caroline

“…Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disease with an age at onset generally below 65 years. Mutations in progranulin…”
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BSCI-10. NEUROLOGICAL DYSFUNCTION CAUSED BY BRAIN TUMOR-GENERATED SOLID STRESS IS REVERSED BY LITHIUM by Seano, Giorgio, Nia, Hadi, Emblem, Kyrre, Datta, Meenal, Ren, Jun, Kloepper, Jonas, Krishnan, Shanmugarajan, Ghosh, Mitrajit, Pinho, Marco, Askoxylakis, Vasileios, Ferraro, Gino, Riedemann, Lars, Gerstner, Elizabeth, Batchelor, Tracy, Wen, Patrick, Lin, Nancy, Grodzinsky, Alan, Fukumura, Dai, Huang, Peigen, Baish, James, Padera, Timothy, Munn, Lance, Jain, Rakesh

“…Abstract The compression of brain tissue by a tumor mass is believed to be a major cause of the clinical symptoms seen in patients. However, the biological…”
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INHIBITING INVASION AND STEMNESS IN GLIOBLASTOMA BY THYMOSIN BETA 4 GENE SILENCING: A POTENTIAL THERAPEUTIC TARGET? by Tabatabai, G., Wirsching, H.-G., Krishnan, S., Florea, A.-M., Frei, K., Krayenbuhl, N., Hasenbach, K., Reifenberger, G., Weller, M.

“…BACKGROUND: Glioblastoma is an incurable primary brain tumors with one of the worst 5-year survival rates among all cancers. Despite multimodal treatment…”
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