Search Results - "Krishnan, Raj K"

Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults by Solomon, Thomas P. J, Sistrun, Sakita N, Krishnan, Raj K, Del Aguila, Luis F, Marchetti, Christine M, O'Carroll, Susan M, O'Leary, Valerie B, Kirwan, John P

“…1 Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; 2 Noll Physiological Research Center, Penn State University,…”
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Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle by Del Aguila, L F, Krishnan, R K, Ulbrecht, J S, Farrell, P A, Correll, P H, Lang, C H, Zierath, J R, Kirwan, J P

“…Physiological stress associated with muscle damage results in systemic insulin resistance. However, the mechanisms responsible for the insulin resistance are…”
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Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat by O'Leary, Valerie B, Marchetti, Christine M, Krishnan, Raj K, Stetzer, Bradley P, Gonzalez, Frank, Kirwan, John P

“…1 Schwartz Center for Metabolism and Nutrition, and Departments of 2 Medicine, 3 Physiology, 4 Nutrition, and 5 Reproductive Biology, Case Western Reserve…”
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Effects of Exercise and Caloric Restriction on Insulin Resistance and Cardiometabolic Risk Factors in Older Obese Adults—A Randomized Clinical Trial by Yassine, Hussein N., Marchetti, Christine M., Krishnan, Raj K., Vrobel, Thomas R., Gonzalez, Frank, Kirwan, John P.

“…Background The prevalence of insulin resistance, metabolic syndrome, and cardiovascular disease is greatest in older obese patients, and effective…”
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A high glycemic meal suppresses the postprandial leptin response in normal healthy adults by Barkoukis, Hope, Marchetti, Christine M, Nolan, Brian, Sistrun, Sakita N, Krishnan, Raj K, Kirwan, John P

“…To evaluate the metabolic effects of meals with varying glycemic index (GI). We measured the glucose, insulin and leptin responses to two contrasting breakfast…”
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Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans by Kelly, Karen R, Williamson, David L, Fealy, Ciarán E, Kriz, David A, Krishnan, Raj K, Huang, Hazel, Ahn, Janice, Loomis, Joseph L, Kirwan, John P

“…Abstract To examine the effects of acute altitude-induced hypoxia on the hormonal and metabolic response to ingested glucose, 8 young, healthy subjects (5 men…”
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Insulin and exercise differentially regulate PI3-kinase and glycogen synthase in human skeletal muscle by O'Gorman, Donal J, Del Aguila, Luis F, Williamson, David L, Krishnan, Raj K, Kirwan, John P

“…1  Noll Physiological Research Center and the General Clinical Research Center, Pennsylvania State University, University Park, Pennsylvania 16802; and…”
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Effects of aging on basal fat oxidation in obese humans by Solomon, Thomas P.J, Marchetti, Christine M, Krishnan, Raj K, Gonzalez, Frank, Kirwan, John P

“…Abstract Basal fat oxidation decreases with age. In obesity, it is not known whether this age-related process occurs independently of changes in body…”
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Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia by Kirwan, J P, Krishnan, R K, Weaver, J A, Del Aguila, L F, Evans, W J

“…Changes in tumor necrosis factor-alpha (TNF-alpha) may provide a mechanism to explain impaired glucose metabolism with advancing age. Hyperglycemic clamps (180…”
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Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle by Kirwan, John P, del Aguila, Luis F, Hernandez, Jazmir M, Williamson, David L, O'Gorman, Donal J, Lewis, Rebecca, Krishnan, Raj K

“…1  Departments of Reproductive Biology and Nutrition, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109;…”
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Impaired substrate oxidation in healthy elderly men after eccentric exercise by Krishnan, Raj K, Evans, William J, Kirwan, John P

“…1  Noll Physiological Research Center and The General Clinical Research Center, The Pennsylvania State University, University Park, Pennsylvania 16802; 2…”
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Glucose clearance is delayed after hyperglycemia in healthy elderly men by Krishnan, Raj K, Evans, William J, Kirwan, John P

“…Delayed glucose clearance after hyperglycemia may contribute to insulin resistance. Rates of glucose and insulin decay were measured after 3 h of sustained…”
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Age-related differences in the pancreatic beta-cell response to hyperglycemia after eccentric exercise by Krishnan, R.K, Hernandez, J.M, Williamson, D.L, O'Gorman, D.J, Evans, W.J, Kirwan, J.P

“…Eccentric exercise (ECC) causes muscle damage, insulin resistance, and increased pancreatic beta-cell secretion in young individuals. However, the effects of…”
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Exercise and Diet Enhance Fat Oxidation and Insulin Sensitivity in Older Obese Adults: 521 May 28 9:30 AM - 9:45 AM by Solomon, Thomas P.J., Sistrun, Sakita N., Krishnan, Raj K., Del Aguila, Luis F., Marchetti, Christine M., O'Carroll, Susan M., O'Leary, Valerie B., Kirwan, John P.

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Inspired substrate oxidation in healthy elderly men after eccentric exercise by Krishnan, Raj K, Evans, William J, Kirwan, John P

“…The metabolic response to eccentric exercise in healthy older adults is unknown. Therefore, substrate metabolism was examined in the basal state and after…”
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Delayed Glucose Clearance In Healthy Older Men Is Related To Abdominal Adiposity by KRISHNAN, RAJ K, HERNANDEZ, JAZMIR M, WILLIAMSON, DAVID L, O'GORMAN, DONAL J, EVANS, WILLIAM J, KIRWAN, JOHN P

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Tumor Necrosis Factor-Alpha is Associated With Impaired Insulin Signaling in Human Skeletal Muscle Following the Stress of Muscle Damage by DEL AGUILA, LUIS F, LEWIS, REBECCA, KRISHNAN, RAJ K, FARRELL, PETER A, LANG, CHARLES H, ULBRECHT, JAN S, CORRELL, PAMELLA H, KIRWAN, JOHN P

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