Search Results - "Krishnan, K. J."

Mitochondrial DNA damage in non-melanoma skin cancer by DURHAM, S. E, KRISHNAN, K. J, BETTS, J, BIRCH-MACHIN, M. A

“…Mitochondrial DNA (mtDNA) damage, predominantly encompassing point mutations, has been reported in a variety of cancers. Here we present in human skin, the…”
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Alpha-synuclein pathology and Parkinsonism associated with POLG1 mutations and multiple mitochondrial DNA deletions by Betts-Henderson, J., Jaros, E., Krishnan, K. J., Perry, R. H., Reeve, A. K., Schaefer, A. M., Taylor, R. W., Turnbull, D. M.

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Dissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle by Campbell, Georgia, Krishnan, Kim J, Deschauer, Marcus, Taylor, Robert W, Turnbull, Doug M

“…Large-scale mitochondrial DNA (mtDNA) deletions are an important cause of mitochondrial disease, while somatic mtDNA deletions cause focal respiratory chain…”
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Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions by Bender, A., Schwarzkopf, R.-M., McMillan, A., Krishnan, K. J., Rieder, G., Neumann, M., Elstner, M., Turnbull, D. M., Klopstock, T.

“…Mitochondrial dysfunction is a consistent finding in neurodegenerative disorders like Alzheimer’s (AD) or Parkinson’s disease (PD) but also in normal human…”
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Do mitochondrial DNA mutations have a role in neurodegenerative disease? by Krishnan, K J, Reeve, A K, Turnbull, D M

“…A decline in mitochondrial function has long been shown to exist in neurodegenerative disease. Whether this decline is a secondary consequence of other factors…”
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COPD and multimorbidity: recognising and addressing a syndemic occurrence by Fabbri, Leonardo M, Celli, Bartolome R, Agustí, Alvar, Criner, Gerard J, Dransfield, Mark T, Divo, Miguel, Krishnan, Jamuna K, Lahousse, Lies, Montes de Oca, Maria, Salvi, Sundeep S, Stolz, Daiana, Vanfleteren, Lowie E G W, Vogelmeier, Claus F

“…Most patients with chronic obstructive pulmonary disease (COPD) have at least one additional, clinically relevant chronic disease. Those with the most severe…”
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Nature of Mitochondrial DNA Deletions in Substantia Nigra Neurons by Reeve, Amy K., Krishnan, Kim J., Elson, Joanna L., Morris, Christopher M., Bender, Andreas, Lightowlers, Robert N., Turnbull, Douglass M.

“…Mitochondrial DNA (mtDNA) deletions have been investigated in a number of neurodegenerative diseases. This study aimed to investigate the characteristics of…”
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ageing mitochondrial genome by Krishnan, Kim J, Greaves, Laura C, Reeve, Amy K, Turnbull, Doug

“…The population of elderly individuals has increased significantly over the past century and is predicted to rise even more rapidly in the future. Ageing is a…”
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A23 NOT A SECOND TIME: SOLUTIONS TO COPD READMISSIONS AND CARE MANAGEMENT: Patient And Index Hospitalization Factors Associated With 30-Day Readmission by Krishnan, J K, Voelker, H, Connett, J, Criner, G J, Niewoehner, D E, Albert, R K, Scanlon, P D, Han, M K, Martinez, F J

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease by Turnbull, Douglass M, Bender, Andreas, Krishnan, Kim J, Morris, Christopher M, Taylor, Geoffrey A, Reeve, Amy K, Perry, Robert H, Jaros, Evelyn, Hersheson, Joshua S, Betts, Joanne, Klopstock, Thomas, Taylor, Robert W

“…Here we show that in substantia nigra neurons from both aged controls and individuals with Parkinson disease, there is a high level of deleted mitochondrial…”
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What causes mitochondrial DNA deletions in human cells? by Krishnan, Kim J, Reeve, Amy K, Samuels, David C, Chinnery, Patrick F, Blackwood, John K, Taylor, Robert W, Wanrooij, Sjoerd, Spelbrink, Johannes N, Lightowlers, Robert N, Turnbull, Doug M

“…Mitochondrial DNA (mtDNA) deletions are a primary cause of mitochondrial disease and are likely to have a central role in the aging of postmitotic tissues…”
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Older mothers are not at risk of having grandchildren with sporadic mtDNA deletions by Elson, Joanna L., Apabhai, Shehnaz, Gorman, Grainne, Whittaker, Roger G., Krishnan, Kim J.

“…Single large-scale mitochondrial DNA deletions account for a quarter of mitochondrial disease cases and occur sporadically with unknown risk factors…”
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C.O.2 DNM2 mutations cause multiple mtDNA deletions in muscle: A novel disorder of mtDNA maintenance by Krishnan, K.J, Nelson, G, Romero, N.B, Ratnaike, T, Blakely, E.L, Ziyadeh-Isleem, A, Miller, J, Murphy, J.L, Horvath, R, Lochmuller, H, Flanigan, K, Turnbull, D.M, Guicheney, P, Bitoun, M, Taylor, R.W

“…Abstract Centronuclear myopathy (CNM) is a congenital myopathy characterised by delayed motor milestones, progressive facial weakness, ptosis, ophthalmoplegia…”
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UV-Induced oxidative stress and its relationship to ageing and nutrition by Aitken, G, Davies, N, Krishnan, K J, Harbottle, A

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The incidence of a novel mitochondrial dna deletion in human skin, as a highly sensitive marker for sunlight exposure by Krishnan, K J, Harbottle, A, Birch Machin, M A

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Late-onset respiratory failure due to TK2 mutations causing multiple mtDNA deletions by Alston, Charlotte L, Schaefer, Andrew M, Raman, Pravrutha, Solaroli, Nicola, Krishnan, Kim J, Blakely, Emma L, He, Langping, Craig, Kate, Roberts, Mark, Vyas, Aashish, Nixon, John, Horvath, Rita, Turnbull, Douglass M, Karlsson, Anna, Gorman, Grainne S, Taylor, Robert W

“…Mutations in nuclear genes involved in the maintenance of mitochondrial DNA (mtDNA) are associated with an extensive spectrum of clinical phenotypes,…”
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The Use of a 3895 bp Mitochondrial DNA Deletion as a Marker for Sunlight Exposure in Human Skin by Krishnan, Kim J., Harbottle, Andrew, Birch-Machin, Mark A.

“…Previous work has examined the use of mitochondrial DNA (mtDNA) damage as a biomarker of cumulative sun exposure in human skin. These studies have simply…”
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Implications of Using the ND1 Gene as a Control Region for Real-Time PCR Analysis of Mitochondrial DNA Deletions in Human Skin by Harbottle, Andrew, Krishnan, Kim J., Birch-Machin, Mark A.

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The Rights of the New Untouchables: A Constitutional Analysis of HIV Jurisprudence in India by Krishnan, Jayanth K.

“…It is believed that India will soon have the highest number of HIV/AIDS cases of any country. Some reports project that 37 million people will be infected…”
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Current pitfalls in the measurement of the 4977 bp mitochondrial DNA common deletion in human skin by KRISHNAN, Kim J, LINDSEY, Janet, LUSHER, Meryl, LOWES, Sarah, BIRCH-MACHIN, Mark A

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