Search Results - "Krishna, Sandeep"
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1
On chaotic dynamics in transcription factors and the associated effects in differential gene regulation
Published in Nature communications (08-01-2019)“…The control of proteins by a transcription factor with periodically varying concentration exhibits intriguing dynamical behaviour. Even though it is accepted…”
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2
Coexistence of phage and bacteria on the boundary of self-organized refuges
Published in Proceedings of the National Academy of Sciences - PNAS (31-07-2012)“…Bacteriophage are voracious predators of bacteria and a major determinant in shaping bacterial life strategies. Many phage species are virulent, meaning that…”
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3
Optimizing testing for COVID-19 in India
Published in PLoS computational biology (22-07-2021)“…COVID-19 testing across India uses a mix of two types of tests. Rapid Antigen Tests (RATs) are relatively inexpensive point-of-care lateral-flow-assay tests,…”
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4
Roles of network topology in the relaxation dynamics of simple chemical reaction network models
Published in Scientific reports (27-09-2024)“…Understanding the relationship between the structure of chemical reaction networks and their reaction dynamics is essential for unveiling the design principles…”
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5
Detection of cooperatively bound transcription factor pairs using ChIP-seq peak intensities and expectation maximization
Published in PloS one (17-07-2018)“…Transcription factors (TFs) often work cooperatively, where the binding of one TF to DNA enhances the binding affinity of a second TF to a nearby location…”
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6
Metabolic constraints drive self-organization of specialized cell groups
Published in eLife (26-06-2019)“…How phenotypically distinct states in isogenic cell populations appear and stably co-exist remains unresolved. We find that within a mature, clonal yeast…”
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Economic and Humanistic Burden of Rheumatoid Arthritis: Results From the US National Survey Data 2018–2020
Published in ACR open rheumatology (01-11-2024)“…Objective Our objective was to estimate the economic and humanistic burden among US adults with rheumatoid arthritis (RA). Methods This study analyzed results…”
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Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community
Published in eLife (02-09-2020)“…Previously, we found that in glucose-limited colonies, metabolic constraints drive cells into groups exhibiting gluconeogenic or glycolytic states. In that…”
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Defence versus growth in a hostile world: lessons from phage and bacteria
Published in Royal Society open science (16-09-2020)“…Bacterial communities are often highly diverse with several closely related species (or strains) coexisting together. These bacteria compete for resources and…”
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10
Simplified models of biological networks
Published in Annual review of biophysics (01-01-2010)“…The function of living cells is controlled by complex regulatory networks that are built of a wide diversity of interacting molecular components. The sheer…”
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Correction: Metabolic constraints drive self-organization of specialized cell groups
Published in eLife (17-12-2020)Get full text
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12
Minimal Model of Spiky Oscillations in NF-κB Signaling
Published in Proceedings of the National Academy of Sciences - PNAS (18-07-2006)“…The NF-κB signaling system is involved in a variety of cellular processes including immune response, inflammation, and apoptosis. Recent experiments have found…”
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In silico Evolution of Lysis-Lysogeny Strategies Reproduces Observed Lysogeny Propensities in Temperate Bacteriophages
Published in Frontiers in microbiology (26-07-2017)“…Bacteriophages are the most abundant organisms on the planet and both lytic and temperate phages play key roles as shapers of ecosystems and drivers of…”
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14
Self-Reproduction and Darwinian Evolution in Autocatalytic Chemical Reaction Systems
Published in Life (Basel, Switzerland) (01-04-2021)“…Understanding the emergence of life from (primitive) abiotic components has arguably been one of the deepest and yet one of the most elusive scientific…”
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15
Learning Reactive Power Control Polices in Distribution Networks Using Conditional Value-at-Risk and Artificial Neural Networks
Published in Journal of modern power systems and clean energy (01-01-2023)“…Scalable coordination of photovoltaic (PV) inverters, considering the uncertainty in PV and load in distribution networks (DNs), is challenging due to the lack…”
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16
Oscillation patterns in negative feedback loops
Published in Proceedings of the National Academy of Sciences - PNAS (17-04-2007)“…Organisms are equipped with regulatory systems that display a variety of dynamical behavior ranging from simple stable steady states, to switching and…”
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17
Toolbox model of evolution of prokaryotic metabolic networks and their regulation
Published in Proceedings of the National Academy of Sciences - PNAS (16-06-2009)“…It has been reported that the number of transcription factors encoded in prokaryotic genomes scales approximately quadratically with their total number of…”
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Correction: Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community
Published in eLife (23-09-2021)Get full text
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19
A model for the emergence of cooperation, interdependence, and structure in evolving networks
Published in Proceedings of the National Academy of Sciences - PNAS (16-01-2001)“…Evolution produces complex and structured networks of interacting components in chemical, biological, and social systems. We describe a simple mathematical…”
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Telemedicine for Patients with Systemic Lupus Erythematosus in a Publicly Funded Hospital System: A Retrospective Study
Published in Interactive journal of medical research (01-11-2024)“…Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that requires frequent clinic and laboratory visits. However, patients with SLE,…”
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