Search Results - "Krippner, Guy"

Platelets in Multiple Sclerosis: Early and Central Mediators of Inflammation and Neurodegeneration and Attractive Targets for Molecular Imaging and Site-Directed Therapy by Orian, Jacqueline M, D'Souza, Claretta S, Kocovski, Pece, Krippner, Guy, Hale, Matthew W, Wang, Xiaowei, Peter, Karlheinz

“…Platelets are clearly central to thrombosis and hemostasis. In addition, more recently, evidence has emerged for non-hemostatic roles of platelets including…”
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Targeting the CDA1/CDA1BP1 Axis Retards Renal Fibrosis in Experimental Diabetic Nephropathy by Chai, Zhonglin, Wu, Tieqiao, Dai, Aozhi, Huynh, Pacific, Koentgen, Frank, Krippner, Guy, Ren, Shuting, Cooper, Mark E

“…Targeting cell division autoantigen 1 (CDA1) is postulated to attenuate the profibrotic actions of transforming growth factor-β in diabetic nephropathy. This…”
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A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein by Zeller, Johannes, Cheung Tung Shing, Karen S, Nero, Tracy L, McFadyen, James D, Krippner, Guy, Bogner, Balázs, Kreuzaler, Sheena, Kiefer, Jurij, Horner, Verena K, Braig, David, Danish, Habiba, Baratchi, Sara, Fricke, Mark, Wang, Xiaowei, Kather, Michel G, Kammerer, Bernd, Woollard, Kevin J, Sharma, Prerna, Morton, Craig J, Pietersz, Geoffrey, Parker, Michael W, Peter, Karlheinz, Eisenhardt, Steffen U

“…C‐reactive protein (CRP) is an early‐stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel…”
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Pharmacokinetics and Tumor Disposition of PEGylated, Methotrexate Conjugated Poly-l-lysine Dendrimers by Kaminskas, Lisa M, Kelly, Brian D, McLeod, Victoria M, Boyd, Ben J, Krippner, Guy Y, Williams, Elizabeth D, Porter, Christopher J. H

“…Dendrimers have potential for delivering chemotherapeutic drugs to solid tumors via the enhanced permeation and retention (EPR) effect. The impact of…”
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The Impact of Molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Poly l-Lysine Dendrimers by Kaminskas, Lisa M, Boyd, Ben J, Karellas, Peter, Krippner, Guy Y, Lessene, Romina, Kelly, Brian, Porter, Christopher J. H

“…The impact of PEGylation on the pharmacokinetics and biodistribution of 3H-labeled poly l-lysine dendrimers has been investigated after intravenous…”
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Structure activity relationship of dendrimer microbicides with dual action antiviral activity by Tyssen, David, Henderson, Scott A, Johnson, Adam, Sterjovski, Jasminka, Moore, Katie, La, Jennifer, Zanin, Mark, Sonza, Secondo, Karellas, Peter, Giannis, Michael P, Krippner, Guy, Wesselingh, Steve, McCarthy, Tom, Gorry, Paul R, Ramsland, Paul A, Cone, Richard, Paull, Jeremy R A, Lewis, Gareth R, Tachedjian, Gilda

“…Topical microbicides, used by women to prevent the transmission of HIV and other sexually transmitted infections are urgently required. Dendrimers are highly…”
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A Versatile Approach for the Site-Specific Modification of Recombinant Antibodies Using a Combination of Enzyme-Mediated Bioconjugation and Click Chemistry by Alt, Karen, Paterson, Brett M., Westein, Erik, Rudd, Stacey E., Poniger, Stan S., Jagdale, Shweta, Ardipradja, Katie, Connell, Timothy U., Krippner, Guy Y., Nair, Ashish K. N., Wang, Xiaowei, Tochon-Danguy, Henri J., Donnelly, Paul S., Peter, Karlheinz, Hagemeyer, Christoph E.

“…A unique two‐step modular system for site‐specific antibody modification and conjugation is reported. The first step of this approach uses enzymatic…”
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The structure of vanin 1: a key enzyme linking metabolic disease and inflammation by Boersma, Ykelien L., Newman, Janet, Adams, Timothy E., Cowieson, Nathan, Krippner, Guy, Bozaoglu, Kiymet, Peat, Thomas S.

“…Although part of the coenzyme A pathway, vanin 1 (also known as pantetheinase) sits on the cell surface of many cell types as an ectoenzyme, catalyzing the…”
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The modified selenenyl amide, M-hydroxy ebselen, attenuates diabetic nephropathy and diabetes-associated atherosclerosis in ApoE/GPx1 double knockout mice by Tan, Sih Min, Sharma, Arpeeta, Yuen, Derek Y C, Stefanovic, Nada, Krippner, Guy, Mugesh, Govindasamy, Chai, Zhonglin, de Haan, Judy B

“…Seleno-organic glutathione peroxidase (GPx) mimetics, including ebselen (Eb), have been tested in in vitro studies for their ability to scavenge reactive…”
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Molecular Dynamics of Poly(l-lysine) Dendrimers with Naphthalene Disulfonate Caps by Roberts, Benjamin P, Scanlon, Martin J, Krippner, Guy Y, Chalmers, David K

“…We have used atomistic molecular dynamics simulations to study the molecular-scale structure of poly(l-lysine) dendrimers homogeneously functionalized with…”
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GPVI and GPIbα mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors by Hu, Houyuan, Armstrong, Paul C J, Khalil, Elie, Chen, Yung-Chih, Straub, Andreas, Li, Min, Soosairajah, Juliana, Hagemeyer, Christoph E, Bassler, Nicole, Huang, Dexing, Ahrens, Ingo, Krippner, Guy, Gardiner, Elizabeth, Peter, Karlheinz

“…Staphylococcus aureus (S. aureus) is a common pathogen capable of causing life-threatening infections. Staphylococcal superantigen-like protein 5 (SSL5) has…”
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Molecular Dynamics of Variegated Polyamide Dendrimers by Roberts, Benjamin P, Krippner, Guy Y, Scanlon, Martin J, Chalmers, David K

“…We have used molecular dynamics simulations to study the structures of a range of heterogeneously functionalized (“variegated”) dendrimers and the…”
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An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus by Feil, Susanne C, Hamilton, Stephanie, Krippner, Guy Y, Lin, Bo, Luttick, Angela, McConnell, Darryl B, Nearn, Roland, Parker, Michael W, Ryan, Jane, Stanislawski, Pauline C, Tucker, Simon P, Watson, Keith G, Morton, Craig J

“…Respiratory infections caused by human rhinovirus are responsible for severe exacerbations of underlying clinical conditions such as asthma in addition to…”
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Impact of Surface Derivatization of Poly-l-lysine Dendrimers with Anionic Arylsulfonate or Succinate Groups on Intravenous Pharmacokinetics and Disposition by Kaminskas, Lisa M, Boyd, Ben J, Karellas, Peter, Henderson, Scott A, Giannis, Michael P, Krippner, Guy Y, Porter, Christopher J. H

“…Tritium-labeled poly-l-lysine dendrimers displaying 8 or 16 surface lysines have been capped with benzene sulfonate (BS), benzene disulfonate (BDS), or…”
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2-Ethoxybenzoxazole as a bioisosteric replacement of an ethyl benzoate group in a human rhinovirus (HRV) capsid binder by Brown, Renee N., Cameron, Rachel, Chalmers, David K., Hamilton, Stephanie, Luttick, Angela, Krippner, Guy Y., McConnell, Darryl B., Nearn, Roland, Stanislawski, Pauline C., Tucker, Simon P., Watson, Keith G.

“…Synthesis and SAR studies of analogues of Pirodavir 2 involving replacement of the benzoate group with various benzo-azole rings led to the discovery of the…”
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Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase by Watson, Keith G., Cameron, Rachel, Fenton, Rob J., Gower, David, Hamilton, Stephanie, Jin, Betty, Krippner, Guy Y., Luttick, Angela, McConnell, Darryl, MacDonald, Simon J.F., Mason, Andy M., Nguyen, Van, Tucker, Simon P., Wu, Wen-Yang

“…A set of trimeric and tetrameric derivatives 6– 11 of the influenza virus neuraminidase inhibitor zanamivir 1 have been synthesized by coupling a common…”
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Improving the membrane permeability of sialic acid derivatives by Altamore, Timothy M., Duggan, Peter J., Krippner, Guy Y.

“…The transport of sialic acid derivatives through a lipophilic membrane, promoted by a boronic acid and an ammonium chloride, was investigated. The potential of…”
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A Versatile Approach for the Site-Specific Modification of Recombinant Antibodies Using a Combination of Enzyme-Mediated Bioconjugation and Click Chemistry by Alt, Karen, Paterson, Brett M., Westein, Erik, Rudd, Stacey E., Poniger, Stan S., Jagdale, Shweta, Ardipradja, Katie, Connell, Timothy U., Krippner, Guy Y., Nair, Ashish K. N., Wang, Xiaowei, Tochon-Danguy, Henri J., Donnelly, Paul S., Peter, Karlheinz, Hagemeyer, Christoph E.

“…A unique two‐step modular system for site‐specific antibody modification and conjugation is reported. The first step of this approach uses enzymatic…”
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An Orally Bioavailable Oxime Ether Capsid Binder with Potent Activity against Human Rhinovirus by Watson, Keith G, Brown, Renee N, Cameron, Rachel, Chalmers, David K, Hamilton, Stephanie, Jin, Betty, Krippner, Guy Y, Luttick, Angela, McConnell, Darryl B, Reece, Phillip A, Ryan, Jane, Stanislawski, Pauline C, Tucker, Simon P, Wu, Wen-Yang, Barnard, Dale L, Sidwell, Robert W

“…A series of capsid-binding compounds was screened against human rhinovirus (HRV) using a CPE based assay. The ethyl oxime ether 14 was found to have…”
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Tethered Neuraminidase Inhibitors That Bind an Influenza Virus: A First Step Towards a Diagnostic Method for Influenza by McKimm-Breschkin, Jennifer L., Colman, Peter M., Jin, Betty, Krippner, Guy Y., McDonald, Mandy, Reece, Phillip A., Tucker, Simon P., Waddington, Lynne, Watson, Keith G., Wu, Wen-Yang

“…Catching flu: The influenza virus neuraminidase inhibitor zanamivir (red) is functionalized at the 7‐position to give derivatives that retain a high affinity…”
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