Search Results - "Krill, M."

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration by McFarland, James M., Ho, Zandra V., Kugener, Guillaume, Dempster, Joshua M., Montgomery, Phillip G., Bryan, Jordan G., Krill-Burger, John M., Green, Thomas M., Vazquez, Francisca, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Tsherniak, Aviad

“…The availability of multiple datasets comprising genome-scale RNAi viability screens in hundreds of diverse cancer cell lines presents new opportunities for…”
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Stem cell therapy for the management of lateral elbow tendinopathy: A systematic literature review by Dakkak, A., Krill, M.L., Fogarty, A., Krill, M.K.

“…Lateral elbow tendinopathy is the most common cause of lateral elbow pain with a lifetime prevalence of approximately 40% in the general population. The…”
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Genomic Selection for Predicting Fusarium Head Blight Resistance in a Wheat Breeding Program by Arruda, Marcio P., Brown, Patrick J., Lipka, Alexander E., Krill, Allison M., Thurber, Carrie, Kolb, Frederic L.

“…Genomic selection (GS) is a breeding method that uses marker–trait models to predict unobserved phenotypes. This study developed GS models for predicting…”
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Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia by Tothova, Zuzana, Krill-Burger, John M., Popova, Katerina D., Landers, Catherine C., Sievers, Quinlan L., Yudovich, David, Belizaire, Roger, Aster, Jon C., Morgan, Elizabeth A., Tsherniak, Aviad, Ebert, Benjamin L.

“…Hematologic malignancies are driven by combinations of genetic lesions that have been difficult to model in human cells. We used CRISPR/Cas9 genome engineering…”
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Development of Al-based multilayer optics for EUV by Meltchakov, E., Hecquet, C., Roulliay, M., De Rossi, S., Menesguen, Y., Jérome, A., Bridou, F., Varniere, F., Ravet-Krill, M.-F., Delmotte, F.

“…We report on the development of multilayer optics for the extreme ultra-violet (EUV) range. The optical performance of Al-based multilayer mirrors is discussed…”
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Association and Linkage Analysis of Aluminum Tolerance Genes in Maize by Krill, Allison M, Kirst, Matias, Kochian, Leon V, Buckler, Edward S, Hoekenga, Owen A

“…Background: Aluminum (Al) toxicity is a major worldwide constraint to crop productivity on acidic soils. Al becomes soluble at low pH, inhibiting root growth…”
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EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression by Renneville, Aline, Van Galen, Peter, Canver, Matthew C., McConkey, Marie, Krill-Burger, John M., Dorfman, David M., Holson, Edward B., Bernstein, Bradley E., Orkin, Stuart H., Bauer, Daniel E., Ebert, Benjamin L.

“…Fetal hemoglobin (HbF, α2γ2) induction is a well-validated strategy for sickle cell disease (SCD) treatment. Using a small-molecule screen, we found that…”
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MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors by Howard, Thomas P, Arnoff, Taylor E, Song, Melinda R, Giacomelli, Andrew O, Wang, Xiaofeng, Hong, Andrew L, Dharia, Neekesh V, Wang, Su, Vazquez, Francisca, Pham, Minh-Tam, Morgan, Ann M, Wachter, Franziska, Bird, Gregory H, Kugener, Guillaume, Oberlick, Elaine M, Rees, Matthew G, Tiv, Hong L, Hwang, Justin H, Walsh, Katherine H, Cook, April, Krill-Burger, John M, Tsherniak, Aviad, Gokhale, Prafulla C, Park, Peter J, Stegmaier, Kimberly, Walensky, Loren D, Hahn, William C, Roberts, Charles W M

“…Malignant rhabdoid tumors (MRT) are highly aggressive pediatric cancers that respond poorly to current therapies. In this study, we screened several MRT cell…”
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Genome‐Wide Association Mapping of Fusarium Head Blight Resistance in Wheat using Genotyping‐by‐Sequencing by Arruda, Marcio P., Brown, Patrick, Brown‐Guedira, Gina, Krill, Allison M., Thurber, Carrie, Merrill, Keith R., Foresman, Bradley J., Kolb, Frederic L.

“…Fusarium head blight (FHB) is one of the most important wheat (Triticum aestivum L.) diseases worldwide, and host resistance displays complex genetic control…”
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Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q by Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Yang, Annan, Kalekar, Radha L., Krill-Burger, John M., Dharia, Neekesh V., Kugener, Guillaume, Kalfon, Jérémie, Yuan, Chen, Dumont, Nancy, Gonzalez, Alfredo, Abdusamad, Mai, Li, Yvonne Y., Spurr, Liam F., Wu, Westley W., Durbin, Adam D., Wolpin, Brian M., Piccioni, Federica, Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.

“…Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new…”
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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML by Tothova, Zuzana, Valton, Anne-Laure, Gorelov, Rebecca A, Vallurupalli, Mounica, Krill-Burger, John M, Holmes, Amie, Landers, Catherine C, Haydu, J Erika, Malolepsza, Edyta, Hartigan, Christina, Donahue, Melanie, Popova, Katerina D, Koochaki, Sebastian, Venev, Sergey V, Rivera, Jeanne, Chen, Edwin, Lage, Kasper, Schenone, Monica, D'Andrea, Alan D, Carr, Steven A, Morgan, Elizabeth A, Dekker, Job, Ebert, Benjamin L

“…The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are…”
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Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q by Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Yang, Annan, Kalekar, Radha L., Krill-Burger, John M., Dharia, Neekesh V., Kugener, Guillaume, Kalfon, Jérémie, Yuan, Chen, Dumont, Nancy, Gonzalez, Alfredo, Abdusamad, Mai, Li, Yvonne Y., Spurr, Liam F., Wu, Westley W., Durbin, Adam D., Wolpin, Brian M., Piccioni, Federica, Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.

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Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiography by LaFramboise, William A, Dhir, Rajiv, Kelly, Lori A, Petrosko, Patricia, Krill-Burger, John M, Sciulli, Christin M, Lyons-Weiler, Maureen A, Chandran, Uma R, Lomakin, Aleksey, Masterson, Robert V, Marroquin, Oscar C, Mulukutla, Suresh R, McNamara, Dennis M

“…More than a million diagnostic cardiac catheterizations are performed annually in the US for evaluation of coronary artery anatomy and the presence of…”
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Renal Cell Neoplasms Contain Shared Tumor Type–Specific Copy Number Variations by Krill-Burger, John M, Lyons, Maureen A, Kelly, Lori A, Sciulli, Christin M, Petrosko, Patricia, Chandran, Uma R, Kubal, Michael D, Bastacky, Sheldon I, Parwani, Anil V, Dhir, Rajiv, LaFramboise, William A

“…Copy number variant (CNV) analysis was performed on renal cell carcinoma (RCC) specimens (chromophobe, clear cell, oncocytoma, papillary type 1, and papillary…”
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Comparing genomic selection and marker-assisted selection for Fusarium head blight resistance in wheat (Triticum aestivum L.) by Arruda, M. P., Lipka, A. E., Brown, P. J., Krill, A. M., Thurber, C., Brown-Guedira, G., Dong, Y., Foresman, B. J., Kolb, F. L.

“…Genomic selection (GS) and marker-assisted selection (MAS) rely on marker–trait associations and are both routinely used for breeding purposes. Although…”
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Defining a Cancer Dependency Map by Tsherniak, Aviad, Vazquez, Francisca, Montgomery, Phil G., Weir, Barbara A., Kryukov, Gregory, Cowley, Glenn S., Gill, Stanley, Harrington, William F., Pantel, Sasha, Krill-Burger, John M., Meyers, Robin M., Ali, Levi, Goodale, Amy, Lee, Yenarae, Jiang, Guozhi, Hsiao, Jessica, Gerath, William F.J., Howell, Sara, Merkel, Erin, Ghandi, Mahmoud, Garraway, Levi A., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C.

“…Most human epithelial tumors harbor numerous alterations, making it difficult to predict which genes are required for tumor survival. To systematically…”
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Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry by Durbin, Adam D., Zimmerman, Mark W., Dharia, Neekesh V., Abraham, Brian J., Iniguez, Amanda Balboni, Weichert-Leahey, Nina, He, Shuning, Krill-Burger, John M., Root, David E., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Golub, Todd R., Young, Richard A., Look, A. Thomas, Stegmaier, Kimberly

“…Childhood high-risk neuroblastomas with MYCN gene amplification are difficult to treat effectively 1 . This has focused attention on tumor-specific gene…”
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Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers by Ito, Takahiro, Young, Michael J., Li, Ruitong, Jain, Sidharth, Wernitznig, Andreas, Krill-Burger, John M., Lemke, Christopher T., Monducci, Davide, Rodriguez, Diego J., Chang, Liang, Dutta, Sanjukta, Pal, Debjani, Paolella, Brenton R., Rothberg, Michael V., Root, David E., Johannessen, Cory M., Parida, Laxmi, Getz, Gad, Vazquez, Francisca, Doench, John G., Zamanighomi, Mahdi, Sellers, William R.

“…Although single-gene perturbation screens have revealed a number of new targets, vulnerabilities specific to frequently altered drivers have not been…”
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A first-generation pediatric cancer dependency map by Dharia, Neekesh V., Kugener, Guillaume, Guenther, Lillian M., Malone, Clare F., Durbin, Adam D., Hong, Andrew L., Howard, Thomas P., Bandopadhayay, Pratiti, Wechsler, Caroline S., Fung, Iris, Warren, Allison C., Dempster, Joshua M., Krill-Burger, John M., Paolella, Brenton R., Moh, Phoebe, Jha, Nishant, Tang, Andrew, Montgomery, Philip, Boehm, Jesse S., Hahn, William C., Roberts, Charles W. M., McFarland, James M., Tsherniak, Aviad, Golub, Todd R., Vazquez, Francisca, Stegmaier, Kimberly

“…Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-burden adult cancers. A key question, however, is whether functional…”
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CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2 by Chen, Liying, Alexe, Gabriela, Dharia, Neekesh V, Ross, Linda, Iniguez, Amanda Balboni, Conway, Amy Saur, Wang, Emily Jue, Veschi, Veronica, Lam, Norris, Qi, Jun, Gustafson, W Clay, Nasholm, Nicole, Vazquez, Francisca, Weir, Barbara A, Cowley, Glenn S, Ali, Levi D, Pantel, Sasha, Jiang, Guozhi, Harrington, William F, Lee, Yenarae, Goodale, Amy, Lubonja, Rakela, Krill-Burger, John M, Meyers, Robin M, Tsherniak, Aviad, Root, David E, Bradner, James E, Golub, Todd R, Roberts, Charles Wm, Hahn, William C, Weiss, William A, Thiele, Carol J, Stegmaier, Kimberly

“…Pharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma,…”
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