Topography of brain atrophy during normal aging and alzheimer's disease

Topography of brain atrophy during normal aging and alzheimer's disease

The present study investigated the effect of age on total and regional brain volumes and compared age-associated changes in 20 healthy controls with those observed in 12 patients with Alzheimer's disease (AD). Weights and volumes of the whole brain and cerebrum, as well as the fractional volume...

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Bibliographic Details
Published in:Neurobiology of aging Vol. 17; no. 4; pp. 513 - 521
Main Authors: Double, K.L., Halliday, G.M., Krill, J.J., Harasty, J.A., Cullen, K., Brooks, W.S., Creasey, H., Broe, G.A.
Format: Journal Article
Language:English
Published: London Elsevier Inc 01-07-1996
Elsevier Science
Subjects:
Age Factors
Aged
Aged, 80 and over
Aging
Aging - pathology
Alzheimer Disease - pathology
Alzheimer's disease
Atrophy
Atrophy - pathology
Biological and medical sciences
Brain Diseases - pathology
Brain volume
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Hippocampus - pathology
Humans
Male
Medical sciences
Middle Aged
Neurology
Sex Factors
Atrophy
Aging
Brain volume
Alzheimer's disease
Human
Nervous system diseases
Senescence
Alzheimer disease
Topography
Central nervous system disease
Central nervous system
Atrophia
Degenerative disease
Cerebral disorder
Brain (vertebrata)
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Summary:The present study investigated the effect of age on total and regional brain volumes and compared age-associated changes in 20 healthy controls with those observed in 12 patients with Alzheimer's disease (AD). Weights and volumes of the whole brain and cerebrum, as well as the fractional volumes of the frontal, temporal, and parieto-occipital cortices, medial temporal structures, deep brain structures, and white matter were measured. Males had larger and heavier brains than females of comparable age. A small decline in brain volume with age was found (approximately 2 ml per year), but only within the white matter. In comparison, no further loss of white matter occurred in AD; however, the cerebral cortex was significantly reduced in volume, with the greatest loss from the medial temporal structures. This loss was related to disease progression; greater proportional loss was associated with more rapid decline in older patients. This study suggests that significant brain atrophy is not a consequence of advancing age. In addition, it suggests a regional specificity of damage in AD.
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ISSN:0197-4580
1558-1497
DOI:10.1016/0197-4580(96)00005-X