Search Results - "Krilis, Steven A."

The Pathogenesis of the Antiphospholipid Syndrome by Giannakopoulos, Bill, Krilis, Steven A

“…The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies. It is associated with obstetrical complications (mainly spontaneous…”
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How we diagnose the antiphospholipid syndrome by Giannakopoulos, Bill, Passam, Freda, Ioannou, Yiannis, Krilis, Steven A.

“…The antiphospholipid syndrome (APS) is an acquired thrombophilia, characterized by the occurrence of venous and arterial events. This article examines the…”
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Free Thiol β2-GPI (β-2-Glycoprotein-I) Provides a Link Between Inflammation and Oxidative Stress in Atherosclerotic Coronary Artery Disease by Weaver, James C., Ullah, Inaam, Qi, Miao, Giannakopoulos, Bill, Rye, Kerry Anne, Kockx, Maaike, Kritharides, Leonard, Krilis, Steven A.

“…OBJECTIVE:Atherosclerotic coronary artery disease is well recognised as an inflammatory disorder that is also influenced by oxidative stress. β2-GPI…”
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How I treat the antiphospholipid syndrome by Giannakopoulos, Bill, Krilis, Steven A.

“…This article discusses how we approach medical decision making in the treatment of the various facets of the antiphospholipid syndrome (APS), including…”
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Naturally occurring free thiols within β2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress–induced cell injury by Ioannou, Yiannis, Zhang, Jing-Yun, Passam, Freda H., Rahgozar, Soheila, Qi, Jian Cheng, Giannakopoulos, Bill, Qi, Miao, Yu, Pei, Yu, Demin M., Hogg, Philip J., Krilis, Steven A.

“…β2-Glycoprotein I (β2GPI) is an evolutionary conserved, abundant circulating protein. Although its function remains uncertain, accumulated evidence points…”
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Essential role for mast cell tryptase in acute experimental colitis by Hamilton, Matthew J, Sinnamon, Mark J, Lyng, Gregory D, Glickman, Jonathan N, Wang, Xueli, Xing, Wei, Krilis, Steven A, Blumberg, Richard S, Adachi, Roberto, Lee, David M, Stevens, Richard L

“…Patients with inflammatory bowel disease (IBD) have increased numbers of human tryptase-β (hTryptase-β)-positive mast cells (MCs) in the gastrointestinal…”
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Improved Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-Control Study by Rahgozar, Soheila, Amirian, Tayebeh, Qi, Miao, Shahshahan, Zahra, Entezar-E-Ghaem, Mansureh, Ghasemi Tehrani, Hatav, Miroliaei, Mehran, Krilis, Steven A, Giannakopoulos, Bill

“…Angiotensinogen exists in two distinct redox forms in plasma, the oxidized sulfhydryl-bridge form and the reduced, unbridged, free thiol form. The oxidized…”
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Intracoronary shear-related up-regulation of platelet P-selectin and platelet-monocyte aggregation despite the use of aspirin and clopidogrel by Yong, Andy S.C., Pennings, Gabrielle J., Chang, Michael, Hamzah, Afiqah, Chung, Tommy, Qi, Miao, Brieger, David, Behnia, Masud, Krilis, Steven A., Ng, Martin K.C., Lowe, Harry C., Kritharides, Leonard

“…Recent in vitro studies have shown that shear stress can cause platelet activation by agonist-independent pathways. However, no studies have assessed the…”
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Beta 2 glycoprotein I is a substrate of thiol oxidoreductases by Passam, Freda H., Rahgozar, Soheila, Qi, Miao, Raftery, Mark J., Wong, Jason W.H., Tanaka, Kumiko, Ioannou, Yiannis, Zhang, Jing Yun, Gemmell, Rosalie, Qi, Jian Chen, Giannakopoulos, Bill, Hughes, Will E., Hogg, Philip J., Krilis, Steven A.

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Factor XI is a substrate for oxidoreductases: Enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis by Giannakopoulos, Bill, Gao, Lu, Qi, Miao, Wong, Jason W, Yu, Demin M, Vlachoyiannopoulos, Panayiotis G, Moutsopoulos, Harry M, Atsumi, Tatsuya, Koike, Takao, Hogg, Philip, Qi, Jian C, Krilis, Steven A

“…Abstract Factor XI (FXI), a disulfide-linked covalent homodimer, circulates in plasma, and upon activation initiates the intrinsic/consolidation phase of…”
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Domain 5 of Beta 2 glycoprotein I: Friend or foe in health? Context matters by Giannakopoulos, Bill, Krilis, Steven A.

“…Beta 2 glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome, an autoimmune disorder characterized by thrombotic and obstetric…”
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The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury by Zhang, Peng, Weaver, James C, Chen, Gang, Beretov, Julia, Atsumi, Tatsuya, Qi, Miao, Bhindi, Ravinay, Qi, Jian C, Madigan, Michele C, Giannakopoulos, Bill, Krilis, Steven A

“…Reperfusion after a period of ischemia results in reperfusion injury (IRI) which involves activation of the inflammatory cascade. In cardiac IRI, IgM natural…”
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Ras Guanine Nucleotide-releasing Protein-4 (RasGRP4) Involvement in Experimental Arthritis and Colitis by Adachi, Roberto, Krilis, Steven A., Nigrovic, Peter A., Hamilton, Matthew J., Chung, Kyungemee, Thakurdas, Shakeel M., Boyce, Joshua A., Anderson, Paul, Stevens, Richard L.

“…RasGRP4 (Rasguanine nucleotide-releasing protein-4) is an intracellular, calcium-regulated guanine nucleotide exchange factor and diacylglycerol/phorbol ester…”
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CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide by Zhou, Saijun, Tanaka, Kumiko, O'Keeffe, Meredith, Qi, Miao, El-Assaad, Fatima, Weaver, James C, Chen, Gang, Weatherall, Christopher, Wang, Ying, Giannakopoulos, Bill, Chen, Liming, Yu, DeMint, Hamilton, Matthew J, Wensing, Lislaine A, Stevens, Richard L, Krilis, Steven A

“…Ras guanine nucleotide-releasing protein-4 (RasGRP4) is an evolutionarily conserved calcium-regulated, guanine nucleotide exchange factor and…”
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Oxidative post-translational modification of βeta 2-glycoprotein I in the pathophysiology of the anti-phospholipid syndrome by Weaver, James C., Krilis, Steven A., Giannakopoulos, Bill

“…The anti-phospholipid syndrome (APS) is a prothrombotic autoimmune disorder characterized by either thrombosis or pregnancy complications in the setting of…”
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Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor by Qi, Jian C., Wang, Jing, Mandadi, Sravan, Tanaka, Kumiko, Roufogalis, Basil D., Madigan, Michele C., Lai, Kenneth, Yan, Feng, Chong, Beng H., Stevens, Richard L., Krilis, Steven A.

“…Interleukin-16 (IL-16) induces the chemotaxis and activation of mast cells (MCs) and other cell types. While it has been concluded that CD4 is the primary…”
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Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing by Douaiher, Jeffrey, Succar, Julien, Lancerotto, Luca, Gurish, Michael F, Orgill, Dennis P, Hamilton, Matthew J, Krilis, Steven A, Stevens, Richard L

“…Mast cells (MCs) are active participants in blood coagulation and innate and acquired immunity. This review focuses on the development of mouse and human MCs,…”
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Laboratory methods to detect antiphospholipid antibodies by Krilis, Steven A, Giannakopoulos, Bill

“…This chapter reviews several important themes pertaining to the antiphospholipid syndrome (APS), including a description of the clinical features, a discussion…”
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Βeta-2-glycoprotein I exerts antithrombotic function through its domain V in mice by Passam, Freda H., Chen, Gang, Chen, Vivien M., Qi, Miao, Krilis, Steven A., Giannakopoulos, Bill

“…Little is known about the physiological role of beta-2-glycoprotein I (β2GPI) despite it being the major auto-antigen in the antiphospholipid syndrome. A…”
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Importance of Mast Cell Prss31/Transmembrane Tryptase/Tryptase-γ in Lung Function and Experimental Chronic Obstructive Pulmonary Disease and Colitis by Hansbro, Philip M., Hamilton, Matthew J., Fricker, Michael, Gellatly, Shaan L., Jarnicki, Andrew G., Zheng, Dominick, Frei, Sandra M., Wong, G. William, Hamadi, Sahar, Zhou, Saijun, Foster, Paul S., Krilis, Steven A., Stevens, Richard L.

“…Protease serine member S31 (Prss31)/transmembrane tryptase/tryptase-γ is a mast cell (MC)-restricted protease of unknown function that is retained on the outer…”
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