Search Results - "Krilis, SA"

International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) by MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., REBER, G., SHOENFELD, Y., TINCANI, A., VLACHOYIANNOPOULOS, P. G., KRILIS, S. A.

“…New clinical, laboratory and experimental insights, since the 1999 publication of the Sapporo preliminary classification criteria for antiphospholipid syndrome…”
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The Pathogenesis of the Antiphospholipid Syndrome by Giannakopoulos, Bill, Krilis, Steven A

“…The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies. It is associated with obstetrical complications (mainly spontaneous…”
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Current concepts on the pathogenesis of the antiphospholipid syndrome by Giannakopoulos, Bill, Passam, Freda, Rahgozar, Soheila, Krilis, Steven A.

“…The antiphospholipid syndrome (APS) is an important cause of acquired thrombophilia. It is characterized by the core clinical manifestations of thrombosis,…”
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How I treat the antiphospholipid syndrome by Giannakopoulos, Bill, Krilis, Steven A.

“…This article discusses how we approach medical decision making in the treatment of the various facets of the antiphospholipid syndrome (APS), including…”
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Mast‐cell growth and differentiation by Li, L, Krilis, SA

“…Abbreviations. MC: mast cell; T: tryptase; C: chymase; CPA: carboxypeptidase A; Bsp‐1: basophil specific antibody 1…”
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Beta 2 glycoprotein I-function in health and disease by Miyakis, Spiros, Giannakopoulos, Bill, Krilis, Steven A.

“…Beta-2 glycoprotein I (β 2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome (APS). It is abundant in human plasma and shares high…”
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Pathogenic role of anti-beta 2-glycoprotein I antibodies in antiphospholipid associated fetal loss: characterisation of beta 2-glycoprotein I binding to trophoblast cells and functional effects of anti-beta 2-glycoprotein I antibodies in vitro by Di Simone, N, Raschi, E, Testoni, C, Castellani, R, D'Asta, M, Shi, T, Krilis, S A, Caruso, A, Meroni, P L

“…Antiphospholipid antibodies reacting with beta2-glycoprotein I (beta 2GPI) have been associated with recurrent fetal loss and pregnancy complications. To…”
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In vivo modulation of angiogenesis by beta 2 glycoprotein I by Passam, F.H, Qi, J.C, Tanaka, K, Matthaei, K.I, Krilis, S.A

“…Abstract Beta 2 glycoprotein I (β2GPI) is the major auto antigen in the antiphospholipid syndrome but also interacts with fibrinolytic and angiogenic proteins…”
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Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor by Qi, Jian C., Wang, Jing, Mandadi, Sravan, Tanaka, Kumiko, Roufogalis, Basil D., Madigan, Michele C., Lai, Kenneth, Yan, Feng, Chong, Beng H., Stevens, Richard L., Krilis, Steven A.

“…Interleukin-16 (IL-16) induces the chemotaxis and activation of mast cells (MCs) and other cell types. While it has been concluded that CD4 is the primary…”
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RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function by Yang, Yi, Li, Lixin, Wong, Guang W, Krilis, Steven A, Madhusudhan, M S, Sali, Andrej, Stevens, Richard L

“…A cDNA was isolated from interleukin 3-developed, mouse bone marrow-derived mast cells (MCs) that contained an insert (designated mRasGRP4) that had not been…”
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Heparin inhibits the binding of beta 2-glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein. Elucidation of the consequences of the two biological events in patients with the anti-phospholipid syndrome by Guerin, Jan, Sheng, Yonghua, Reddel, Stephen, Iverson, G Michael, Chapman, Michael G, Krilis, Steven A

“…The phospholipid-binding plasma protein beta2-glycoprotein I (beta2-GPI) is the primary antigen recognized by the circulating autoantibodies in patients with…”
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Biochemical and Functional Characterization of Human Transmembrane Tryptase (TMT)/Tryptase γ by Wong, Guang W., Foster, Paul S., Yasuda, Shinsuke, Qi, Jian C., Mahalingam, Surendran, Mellor, Elizabeth A., Katsoulotos, Gregory, Li, Lixin, Boyce, Joshua A., Krilis, Steven A., Stevens, Richard L.

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Epitope Studies with Anti- beta -glycoprotein I Antibodies from Autoantibody and Immunized Sources by Reddel, S W, Wang, Y X, Sheng, Y H, Krilis, SA

“…This paper examines the methodology of anti- beta sub(2)-glycoprotein I ( beta sub(2)-GPI) epitope determination and provides further epitope studies using…”
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Human Tryptase ε (PRSS22), a New Member of the Chromosome 16p13.3 Family of Human Serine Proteases Expressed in Airway Epithelial Cells by Wong, Guang W., Yasuda, Shinsuke, Madhusudhan, Mallur S., Li, Lixin, Yang, Yi, Krilis, Steven A., Šali, Andrej, Stevens, Richard L.

“…Probing of the GenBankTMexpressed sequence tag (EST) data base with varied human tryptase cDNAs identified two truncated ESTs that subsequently were found to…”
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Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft by Huang, C, Li, L, Krilis, S A, Chanasyk, K, Tang, Y, Li, Z, Hunt, J E, Stevens, R L

“…Tryptases alpha and beta/II were expressed in insect cells to try to ascertain why human mast cells express these two nearly identical granule proteases. In…”
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Laboratory tests for the antiphospholipid syndrome: current concepts by Passam, Freda H., Krilis, Steven A.

“…There is increased scientific interest in the diagnosis of the antiphospholipid syndrome (APS), as therapeutic interventions can lead to substantial…”
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Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4 by Li, Yong, Li, Lixin, Wadley, Robert, Reddel, Stephen W., Qi, Jian C., Archis, Con, Collins, Andrew, Clark, Elizabeth, Cooley, Margaret, Kouts, Steven, Naif, Hassan M., Alali, Mohammed, Cunningham, Anthony, Wong, Guang W., Stevens, Richard L., Krilis, Steven A.

“…A population of metachromatic cells with mast cell (MC) and basophil features was identified recently in the peripheral blood of patients with several allergic…”
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Beta-2 glycoprotein I and its role in antiphospholipid syndrome—lessons from knockout mice by Miyakis, Spiros, Robertson, Sarah A, Krilis, Steven A

“…The antiphospholipid syndrome is characterized by the presence in serum of autoantibodies against β 2GPI. Although the role of β 2GPI in the pathogenesis of…”
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Human beta 2-glycoprotein I binds to endothelial cells through a cluster of lysine residues that are critical for anionic phospholipid binding and offers epitopes for anti-beta 2-glycoprotein I antibodies by Del Papa, N, Sheng, Y H, Raschi, E, Kandiah, D A, Tincani, A, Khamashta, M A, Atsumi, T, Hughes, G R, Ichikawa, K, Koike, T, Balestrieri, G, Krilis, S A, Meroni, P L

“…Beta 2-Glycoprotein I (beta 2GPI) is a phospholipid-binding protein recognized by serum autoantibodies from the anti-phospholipid syndrome both in cardiolipin-…”
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Identification of a New Member of the Tryptase Family of Mouse and Human Mast Cell Proteases Which Possesses a Novel COOH-terminal Hydrophobic Extension by Wong, Guang W., Tang, Yinzi, Feyfant, Eric, Šali, Andrej, Li, Lixin, Li, Yong, Huang, Chifu, Friend, Daniel S., Krilis, Steven A., Stevens, Richard L.

“…Mapping of the tryptase locus on chromosome 17 revealed a novel gene 2.3 kilobase 3′ of the mouse mast cell protease (mMCP) 6 gene. This 3.7-kilobase gene…”
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