Search Results - "Krilis, S A"

International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) by MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., REBER, G., SHOENFELD, Y., TINCANI, A., VLACHOYIANNOPOULOS, P. G., KRILIS, S. A.

“…New clinical, laboratory and experimental insights, since the 1999 publication of the Sapporo preliminary classification criteria for antiphospholipid syndrome…”
Get full text

Pathogenic role of anti-β2-glycoprotein I antibodies in antiphospholipid associated fetal loss: characterisation of β2-glycoprotein I binding to trophoblast cells and functional effects of anti-β2-glycoprotein I antibodies in vitro by Di Simone, N, Raschi, E, Testoni, C, Castellani, R, D’Asta, M, Shi, T, Krilis, S A, Caruso, A, Meroni, P L

“…Background: Antiphospholipid antibodies reacting with β2-glycoprotein I (β2GPI) have been associated with recurrent fetal loss and pregnancy complications…”
Get full text

In vivo modulation of angiogenesis by beta 2 glycoprotein I by Passam, F.H, Qi, J.C, Tanaka, K, Matthaei, K.I, Krilis, S.A

“…Abstract Beta 2 glycoprotein I (β2GPI) is the major auto antigen in the antiphospholipid syndrome but also interacts with fibrinolytic and angiogenic proteins…”
Get full text

Mast‐cell growth and differentiation by Li, L, Krilis, SA

“…Abbreviations. MC: mast cell; T: tryptase; C: chymase; CPA: carboxypeptidase A; Bsp‐1: basophil specific antibody 1…”
Get full text

Clinical relevance of nitrated beta 2-glycoprotein I in antiphospholipid syndrome: Implications for thrombosis risk by Krilis, M., Qi, M., Ioannou, Y., Zhang, J.Y., Ahmadi, Z., Wong, J.W.H., Vlachoyiannopoulos, P.G., Moutsopoulos, H.M., Koike, T., Sturgess, A.D., Chong, B.H., Krilis, S.A., Giannakopoulos, B.

“…Β2-Glycoprotein I (β2GPI) is an important anti-thrombotic protein and is the major auto-antigen in the antiphospholipid syndrome (APS). The clinical relevance…”
Get full text

Molecular pathophysiology of the antiphospholipid syndrome: the role of oxidative post‐translational modification of beta 2 glycoprotein I by PASSAM, F. H., GIANNAKOPOULOS, B., MIRARABSHAHI, P., KRILIS, S. A.

“…It has been well established that antiphospholipid antibodies and specifically those directed against beta 2 glycoprotein I (β2GPI) are pathogenic for the…”
Get full text

Immunology and clinical importance of antiphospholipid antibodies by McNeil, H P, Chesterman, C N, Krilis, S A

“…Having reviewed the literature on the association of aPL antibodies with clinical manifestations, it is clear that this group of autoantibodies are of…”
Get more information

Risk stratification and outcome of cellulitis admitted to hospital by Figtree, M, Konecny, P, Jennings, Z, Goh, C, Krilis, S.A, Miyakis, S

“…Summary Objectives To identify risk factors associated with mortality and adverse outcome of community acquired cellulitis/erysipelas requiring hospital…”
Get full text

Redox control of β2‐glycoprotein I–von Willebrand factor interaction by thioredoxin‐1 by PASSAM, F. H., RAHGOZAR, S., QI, M., RAFTERY, M. J, WONG, J. W. H., TANAKA, K., IOANNOU, Y., ZHANG, J. Y., GEMMELL, R., QI, J. C., GIANNAKOPOULOS, B., HUGHES, W. E., HOGG, P. J., KRILIS, S. A.

“…Background: β2‐Glycoprotein I (β2GPI) is an abundant plasma protein that is closely linked to blood clotting, as it interacts with various protein and cellular…”
Get full text

A phospholipid-beta 2-glycoprotein I complex is an antigen for anticardiolipin antibodies occurring in autoimmune disease but not with infection by Hunt, J E, McNeil, H P, Morgan, G J, Crameri, R M, Krilis, S A

“…Anticardiolipin antibodies (aCL) purified from patients with autoimmune disease have recently been shown to interact with a phospholipid-binding plasma…”
Get more information

Association of mast cells with fibrosis and fatty infiltration in the minor salivary glands of patients with Sjögren's syndrome by Skopouli, F N, Li, L, Boumba, D, Stefanaki, S, Hanel, K, Moutsopoulos, H M, Krilis, S A

“…To determine the distribution and density of mast cells in the minor salivary glands of patients with primary Sjögren's syndrome (pSS) and of normal controls…”
Get more information

Pathogenic role of anti-beta 2-glycoprotein I antibodies in antiphospholipid associated fetal loss: characterisation of beta 2-glycoprotein I binding to trophoblast cells and functional effects of anti-beta 2-glycoprotein I antibodies in vitro by Di Simone, N, Raschi, E, Testoni, C, Castellani, R, D'Asta, M, Shi, T, Krilis, S A, Caruso, A, Meroni, P L

“…Antiphospholipid antibodies reacting with beta2-glycoprotein I (beta 2GPI) have been associated with recurrent fetal loss and pregnancy complications. To…”
Get full text

Detection of ‘antiphospholipid’ antibodies: a single chromogenic assay of thrombin generation sensitively detects lupus anticoagulants, anticardiolipin antibodies, plus antibodies binding β2‐glycoprotein I and prothrombin by Sheng, Y., Hanly, J. G., Reddel, S. W., Kouts, S., Guerin, J., Koike, T., Ichikawa, K., Sturgess, A., Krilis, S. A.

“…The diagnosis of the antiphospholipid syndrome (APS) requires both a typical clinical event plus a persistently positive test in an assay for either…”
Get full text

Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population by Shi, W, Krilis, S A, Chong, B H, Gordon, S, Chesterman, C N

“…This study was designed to explore the incidence of lupus anticoagulant (LA) and anticardiolipin antibodies (ACA) and their relationship to each other in a…”
Get more information

Identification of a Region of β2-Glycoprotein I Critical for Lipid Binding and Anti-Cardiolipin Antibody Cofactor Activity by Hunt, J. E., Simpson, R. J., Krilis, S. A.

“…β2-Glycoprotein I (β2-GPI), a phospholipid-binding plasma protein, is an absolute requirement (cofactor) for the binding of autoimmune-type anti-cardiolipin…”
Get full text

Purification of antiphospholipid antibodies using a new affinity method by McNeil, H P, Krilis, S A, Chesterman, C N

Get more information

Laboratory detection of antiphospholipid antibodies by Kandiah, D A, Krilis, S A

“…'Antiphospholipid' (aPL) antibodies are a heterogenous group of autoantibodies that are now considered to be directed mainly to plasma proteins or…”
Get more information

Immunology of antiphospholipid antibodies and their interaction with plasma proteins by Kandiah, D A, Krilis, S A

“…'Antiphospholipid' (aPL) antibodies are of clinical importance because of their strong association with vascular thrombosis, recurrent pregnancy loss,…”
Get more information

Anti-β2-glycoprotein I autoantibodies require an antigen density threshold, consistent with divalent binding by Reddel, S W, Wang, Y X, Krilis, S A

“…Autoantibodies binding β2-glycoprotein I (B2GPI) are an important finding in the antiphospholipid syndrome. While antibodies from mice or rabbits immunized…”
Get full text

Modulation of endothelial cell function by antiphospholipid antibodies by Meroni, P L, Del Papa, N, Beltrami, B, Tincani, A, Balestrieri, G, Krilis, S A

“…beta 2-glycoprotein I (beta 2-GP-I) the plasma cofactor for anti-phospholipid antibodies adheres on the endothelial surfaces and can be recognized by anti-beta…”
Get more information