Search Results - "Kries, Kelly"

Wolfram syndrome 1 gene regulates pathways maintaining beta-cell health and survival by Abreu, Damien, Asada, Rie, Revilla, John M. P., Lavagnino, Zeno, Kries, Kelly, Piston, David W., Urano, Fumihiko

“…Wolfram Syndrome 1 (WFS1) protein is an endoplasmic reticulum (ER) factor whose deficiency results in juvenile-onset diabetes secondary to cellular dysfunction…”
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Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells by Stone, Stephen, Abreu, Damien, Mahadevan, Jana, Asada, Rie, Kries, Kelly, Graf, Rolf, Marshall, Bess A., Hershey, Tamara, Urano, Fumihiko

“…Endoplasmic reticulum (ER) stress in beta cells is an important pathogenic component of both type 1 and type 2 diabetes mellitus, as well as genetic forms of…”
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G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells by Corbet, Andrea K., Bikorimana, Emmanuel, Boyd, Raya I., Shokry, Doha, Kries, Kelly, Gupta, Ayush, Paton, Anneliese, Sun, Zhengyang, Fazal, Zeeshan, Freemantle, Sarah J., Nelson, Erik R., Spinella, Michael J., Singh, Ratnakar

“…•G0S2 has a complex role in breast cancer, dependent on ER status and partially mediated by suppression of estrogen signaling pathways.•Overexpression of G0S2…”
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A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome by Abreu, Damien, Stone, Stephen I, Pearson, Toni S, Bucelli, Robert C, Simpson, Ashley N, Hurst, Stacy, Brown, Cris M, Kries, Kelly, Onwumere, Chinyere, Gu, Hongjie, Hoekel, James, Tychsen, Lawrence, Van Stavern, Gregory P, White, Neil H, Marshall, Bess A, Hershey, Tamara, Urano, Fumihiko

“…BACKGROUNDWolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration…”
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Multidimensional analysis and therapeutic development using patient iPSC-derived disease models of Wolfram syndrome by Kitamura, Rie Asada, Maxwell, Kristina G, Ye, Wenjuan, Kries, Kelly, Brown, Cris M, Augsornworawat, Punn, Hirsch, Yoel, Johansson, Martin M, Weiden, Tzvi, Ekstein, Joseph, Cohen, Joshua, Klee, Justin, Leslie, Kent, Simeonov, Anton, Henderson, Mark J, Millman, Jeffrey R, Urano, Fumihiko

“…Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy,…”
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eP264: Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome by Urano, Fumihiko, Kitamura, Rie Asada, Maxwell, Kristina, Ye, Wenjuan, Kries, Kelly, Brown, Cris, Augsornworawat, Punn, Johansson, Martin, Cohen, Joshua, Klee, Justin, Leslie, Kent, Simeonov, Anton, Hirsch, Joel, Weiden, Tzvi, Henderson, Mark, Millman, Jeffrey, Ekstein, Josef

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Colour vision variation in leaf‐nosed bats (Phyllostomidae): Links to cave roosting and dietary specialization by Kries, Kelly, Barros, Marília A. S., Duytschaever, Gwen, Orkin, Joseph D., Janiak, Mareike C., Pessoa, Daniel M. A., Melin, Amanda D.

“…Bats are a diverse radiation of mammals of enduring interest for understanding the evolution of sensory specialization. Colour vision variation among species…”
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85-LB: A Phase 1b/2 Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome by ABREU, DAMIEN, PEARSON, TONI S., BUCELLI, ROBERT C., SIMPSON, ASHLEY, BROWN, CRIS M., KRIES, KELLY, GU, HONGJIE, STONE, STEPHEN I., TYCHSEN, LAWRENCE, STAVERN, GREGORY VAN, WHITE, NEIL H., MARSHALL, BESS A., HERSHEY, TAMARA, URANO, FUMIHIKO

“…Wolfram syndrome is a rare, progressive neurodegenerative disorder characterized by juvenile-onset diabetes, optic nerve atrophy and mutation of the WFS1 gene…”
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A phase 1b/2a clinical trial of dantrolene sodium in patients with Wolfram syndrome by Abreu, Damien, Stone, Stephen I., Pearson, Toni S., Bucelli, Robert C., Simpson, Ashley N., Hurst, Stacy, Brown, Cris M., Kries, Kelly, Onwumere, Chinyere, Gu, Hongjie, Hoekel, James, Tychsen, Lawrence, Van Stavern, Gregory P., White, Neil H., Marshall, Bess A., Hershey, Tamara, Urano, Fumihiko

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