Search Results - "Kriegsheim, A. von"

RASSF2 associates with and stabilizes the proapoptotic kinase MST2 by Cooper, W N, Hesson, L B, Matallanas, D, Dallol, A, von Kriegsheim, A, Ward, R, Kolch, W, Latif, F

“…RASSF2 is a tumour suppressor that in common with the rest of the RASSF family contains Ras association and SARAH domains. We identified the proapoptotic…”
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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation by Jaakkola, Panu, Mole, David R., Tian, Ya-Min, Wilson, Michael I., Gielbert, Janine, Gaskell, Simon J., von Kriegsheim, Alexander, Hebestreit, Holger F., Mukherji, Mridul, Schofield, Christopher J., Maxwell, Patrick H., Pugh, Christopher W., Ratcliffe, Peter J.

“…Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron…”
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293: MNT roles and expression in the absence of MAX by Lafita, M.C, Quintanilla, A, Rodríguez, J, Varela, I, Von Kriegsheim, A, León, J

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In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells by Lesniak, A, Kilinc, D, Rashdan, Suad A, von Kriegsheim, A, Ashall, B, Zerulla, D, Kolch, W, Lee, G U

“…Multifunctional nanoparticles that actively target specific cells are promising tools for cancer diagnosis and therapy. In this article we review the synthesis…”
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11 From benchside to byteside: what we can learn from computational modelling by Kolch, W, Birtwistle, M, Kholodenko, B, Grindlay, J, Sturm, O, Orton, R, Gilbert, D, von Kriegsheim, A

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Raf family kinases: old dogs have learned new tricks by Matallanas, David, Birtwistle, Marc, Romano, David, Zebisch, Armin, Rauch, Jens, von Kriegsheim, Alexander, Kolch, Walter

“…First identified in the early 1980s as retroviral oncogenes, the Raf proteins have been the objects of intense research. The discoveries 10 years later that…”
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P076 Dock2 acts as a tumour suppressor via immune cell regulation of IDO1 in Inflammatory Bowel Disease–associated colorectal cancer by Churchhouse MD, A, Billard, C V, Pohl, S Ö, Donnelly, K, Suzuki, T, Von Kriegsheim, A, Arends, M J, Coffelt, S B, Myant, K B

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PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359 by Rodriguez, Javier, Herrero, Ana, Li, Shuijie, Rauch, Nora, Quintanilla, Andrea, Wynne, Kieran, Krstic, Aleksandar, Acosta, Juan Carlos, Taylor, Cormac, Schlisio, Susanne, von Kriegsheim, Alex

“…Cellular p53 protein levels are regulated by a ubiquitination/de-ubiquitination cycle that can target the protein for proteasomal destruction. The…”
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EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance by Li, Shuijie, Rodriguez, Javier, Li, Wenyu, Bullova, Petra, Fell, Stuart M., Surova, Olga, Westerlund, Isabelle, Topcic, Danijal, Bergsland, Maria, Stenman, Adam, Muhr, Jonas, Nistér, Monica, Holmberg, Johan, Juhlin, C. Christofer, Larsson, Catharina, von Kriegsheim, Alex, Kaelin, William G., Schlisio, Susanne

“…Despite the discovery of the oxygen-sensitive regulation of HIFα by the von Hippel–Lindau (VHL) protein, the mechanisms underlying the complex…”
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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation by Jaakkola, Panu, Mole, David R., Tian, Ya-Min, Wilson, Michael I., Gielbert, Janine, Gaskell, Simon J., Kriegsheim, Alexander von, Hebestreit, Holger F., Mukherji, Mridul, Schofield, Christopher J., Maxwell, Patrick H., Pugh, ‡ Christopher W., Ratcliffe, ‡ Peter J.

“…Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron…”
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Abstract P4-08-02: Understanding the mechanisms of action underlying the role of IL6ST, a key biomarker for prediction of response to endocrine therapy by Turnbull, AK, Fernando, A, Martinez-Perez, C, Finch, AJ, von Kriegsheim, A, Wills, J, Quinn, N, Selli, C, Mosley, D, Langdon, SP, Sims, AH, Dixon, JM

“…Introduction: IL6ST is regarded as a putative ER target gene. Recently it has been recognised as a key biomarker for prediction of response to endocrine…”
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Abstract P3-12-24: Tumor-secreted predictive biomarkers of response to radiotherapy in breast cancer by Meehan, J, Gray, M, Turnbull, AK, Martinez-Perez, C, Bonello, M, Ward, C, Langdon, SP, McLaughlin, S, MacLennan, M, Dixon, JM, Wills, J, Quinn, N, Finich, AJ, von Kriegsheim, A, Cameron, D, Kunkler, IH, Murray, A, Argyle, D

“…Background:In breast cancer (BC), radiotherapy (RT) is used adjuvantly to prevent recurrence and also in the palliative setting. Clinical signs of RT response…”
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Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome by Li, Shuijie, Li, Wenyu, Yuan, Juan, Bullova, Petra, Wu, Jieyu, Zhang, Xuepei, Liu, Yong, Plescher, Monika, Rodriguez, Javier, Bedoya-Reina, Oscar C., Jannig, Paulo R., Valente-Silva, Paula, Yu, Meng, Henriksson, Marie Arsenian, Zubarev, Roman A., Smed-Sörensen, Anna, Suzuki, Carolyn K., Ruas, Jorge L., Holmberg, Johan, Larsson, Catharina, Christofer Juhlin, C., von Kriegsheim, Alex, Cao, Yihai, Schlisio, Susanne

“…Mitochondria are the main consumers of oxygen within the cell. How mitochondria sense oxygen levels remains unknown. Here we show an oxygen-sensitive…”
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WS14.3 Hypoxia reduces the virulence of Pseudomonas aeruginosa by Schaible, B, Rodriguez, J, Garcia, A, Kriegsheim, A. von, McClean, S, Taylor, C.T, Schaffer, K

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A novel role of MNT as a negative regulator of REL and the NF-κB pathway by Liaño-Pons, Judit, Lafita-Navarro, M. Carmen, García-Gaipo, Lorena, Colomer, Carlota, Rodríguez, Javier, von Kriegsheim, Alex, Hurlin, Peter J., Ourique, Fabiana, Delgado, M. Dolores, Bigas, Anna, Espinosa, Lluis, León, Javier

“…MNT, a transcription factor of the MXD family, is an important modulator of the oncoprotein MYC. Both MNT and MYC are basic-helix–loop–helix proteins that…”
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Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome by Li, Shuijie, Li, Wenyu, Yuan, Juan, Bullova, Petra, Wu, Jieyu, Zhang, Xuepei, Liu, Yong, Plescher, Monika, Rodriguez, Javier, Bedoya-Reina, Oscar C., Jannig, Paulo R., Valente-Silva, Paula, Yu, Meng, Henriksson, Marie Arsenian, Zubarev, Roman A., Smed-Sörensen, Anna, Suzuki, Carolyn K., Ruas, Jorge L., Holmberg, Johan, Larsson, Catharina, Christofer Juhlin, C., von Kriegsheim, Alex, Cao, Yihai, Schlisio, Susanne

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Towards complete analysis of the platelet proteome by O'Neill, Eric E., Brock, Chris J., von Kriegsheim, Alexander F., Pearce, Andrew C., Dwek, Raymond A., Watson, Steve P., Hebestreit, Holger F.

“…Platelets exert a crucial function in haemostasis, wound repair, and the formation of vascular plugs, underlying thrombotic diseases such as stroke and…”
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Targeting of HIF- alpha to the von Hippel-Lindau ubiquitilation complex by O sub(2)-regulated prolyl hydroxylation by Jaakkola, P, Mole, DR, Tian, Ya-Min, Wilson, MI, Gielbert, J, Gaskell, S J, von Kriegsheim, A, Hebestreit, H F, Mukherji, M, Schofield, C J, Maxwell, PH, Pugh, C W, Ratcliffe, P J

“…Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron…”
Get full text