Search Results - "Kriegs, Malte"

Improving the Efficacy of Tumor Radiosensitization Through Combined Molecular Targeting by Hintelmann, Katharina, Kriegs, Malte, Rothkamm, Kai, Rieckmann, Thorsten

“…Chemoradiation, either alone or in combination with surgery or induction chemotherapy, is the current standard of care for most locally advanced solid tumors…”
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Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K521 Polymorphism by Braig, Friederike, Kriegs, Malte, Voigtlaender, Minna, Habel, Beate, Grob, Tobias, Biskup, Karina, Blanchard, Veronique, Sack, Markus, Thalhammer, Anja, Ben Batalla, Isabel, Braren, Ingke, Laban, Simon, Danielczyk, Antje, Goletz, Steffen, Jakubowicz, Elzbieta, Märkl, Bruno, Trepel, Martin, Knecht, Rainald, Riecken, Kristoffer, Fehse, Boris, Loges, Sonja, Bokemeyer, Carsten, Binder, Mascha

“…Abstract Head and neck squamous cell carcinomas (HNSCC) exhibiting resistance to the EGFR-targeting drug cetuximab poses a challenge to their effective…”
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Photoswitchable Azo- and Diazocine-Functionalized Derivatives of the VEGFR-2 Inhibitor Axitinib by Heintze, Linda, Schmidt, Dorian, Rodat, Theo, Witt, Lydia, Ewert, Julia, Kriegs, Malte, Herges, Rainer, Peifer, Christian

“…In this study, we aimed at the application of the concept of photopharmacology to the approved vascular endothelial growth factor receptor (VEGFR)-2 kinase…”
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The failure of cetuximab-based de-intensified regimes for HPV-positive OPSCC: A radiobiologists perspective by Rieckmann, Thorsten, Kriegs, Malte

“…[Display omitted] •Recent trial results show inferiority of cetuximab- to cisplatin-radiotherapy in HPV+ OPSCC.•Previous data also question the benefit of…”
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EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma by Struve, Nina, Binder, Zev A., Stead, Lucy F., Brend, Tim, Bagley, Stephen J., Faulkner, Claire, Ott, Leonie, Müller-Goebel, Justus, Weik, Anna-Sophie, Hoffer, Konstantin, Krug, Leonie, Rieckmann, Thorsten, Bußmann, Lara, Henze, Marvin, Morrissette, Jennifer J. D., Kurian, Kathreena M., Schüller, Ulrich, Petersen, Cordula, Rothkamm, Kai, O´ Rourke, Donald M., Short, Susan C., Kriegs, Malte

“…The oncogene epidermal growth factor receptor variant III (EGFRvIII) is frequently expressed in glioblastomas (GBM) but its impact on therapy response is still…”
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Analyzing expression and phosphorylation of the EGF receptor in HNSCC by Kriegs, Malte, Clauditz, Till Sebastian, Hoffer, Konstantin, Bartels, Joanna, Buhs, Sophia, Gerull, Helwe, Zech, Henrike Barbara, Bußmann, Lara, Struve, Nina, Rieckmann, Thorsten, Petersen, Cordula, Betz, Christian Stephan, Rothkamm, Kai, Nollau, Peter, Münscher, Adrian

“…Overexpression of the epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinomas (HNSCC) is considered to cause increased EGFR activity,…”
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Light-controlled inhibition of BRAFV600E kinase by Hoorens, Mark W.H., Ourailidou, Maria E., Rodat, Theo, van der Wouden, Petra E., Kobauri, Piermichele, Kriegs, Malte, Peifer, Christian, Feringa, Ben L., Dekker, Frank J., Szymanski, Wiktor

“…Metastatic melanoma is amongst the most difficult types of cancer to treat, with current therapies mainly relying on the inhibition of the BRAFV600E mutant…”
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Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties by Dyshlovoy, Sergey A., Kaune, Moritz, Kriegs, Malte, Hauschild, Jessica, Busenbender, Tobias, Shubina, Larisa K., Makarieva, Tatyana N., Hoffer, Konstantin, Bokemeyer, Carsten, Graefen, Markus, Stonik, Valentin A., von Amsberg, Gunhild

“…Monanchoxymycalin C (MomC) is a new marine pentacyclic guanidine alkaloid, recently isolated from marine sponge Monanchora pulchra by us. Here, anticancer…”
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Synthesis and new DNA targeting activity of 6- and 7-tert-butylfascaplysins by Dyshlovoy, Sergey A., Mansour, Wael Y., Ramm, Natalia A., Hauschild, Jessica, Zhidkov, Maxim E., Kriegs, Malte, Zielinski, Alexandra, Hoffer, Konstantin, Busenbender, Tobias, Glumakova, Ksenia A., Spirin, Pavel V., Prassolov, Vladimir S., Tilki, Derya, Graefen, Markus, Bokemeyer, Carsten, von Amsberg, Gunhild

“…Fascaplysin is a red cytotoxic pigment with anticancer properties isolated from the marine sponge Fascaplysinopsis sp. Recently, structure–activity…”
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Axitinib: A Photoswitchable Approved Tyrosine Kinase Inhibitor by Schmidt, Dorian, Rodat, Theo, Heintze, Linda, Weber, Jantje, Horbert, Rebecca, Girreser, Ulrich, Raeker, Tim, Bußmann, Lara, Kriegs, Malte, Hartke, Bernd, Peifer, Christian

“…The goal of photopharmacology is to develop photoswitchable enzyme modulators as tunable (pro‐)drugs that can be spatially and temporally controlled by light…”
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EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks by MENG WANG, MORSBACH, Fabian, DAHM-DAPHI, Jochen, SETTLEMAN, Jeffrey, WILLERS, Henning, SANDER, David, GHEORGHIU, Liliana, NANDA, Akash, BENES, Cyril, KRIEGS, Malte, KRAUSE, Mechthild, DIKOMEY, Ekkehard, BAUMANN, Michael

“…The mechanisms by which inhibition of the epidermal growth factor receptor (EGFR) sensitizes non-small cell lung cancer (NSCLC) cells to ionizing radiation…”
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Cytotoxic N-Methylpretrichodermamide B Reveals Anticancer Activity and Inhibits P-Glycoprotein in Drug-Resistant Prostate Cancer Cells by Dyshlovoy, Sergey A., Busenbender, Tobias, Hauschild, Jessica, Girich, Elena V., Kriegs, Malte, Hoffer, Konstantin, Graefen, Markus, Yurchenko, Anton N., Bokemeyer, Carsten, von Amsberg, Gunhild

“…N-methylpretrichodermamide B (NB) is a biologically active epidithiodiketopiperazine isolated from several strains of the algae-derived fungus Penicillium sp…”
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Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway by Ehm, Patrick A H, Horn, Stefan, Hoffer, Konstantin, Kriegs, Malte, Horn, Michael, Giehler, Susanne, Nalaskowski, Marcus, Rehbach, Christoph, Horstmann, Martin A, Jücker, Manfred

“…Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by raising the…”
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The epidermal growth factor receptor modulates DNA double-strand break repair by regulating non-homologous end-joining by Kriegs, Malte, Kasten-Pisula, Ulla, Rieckmann, Thorsten, Holst, Katharina, Saker, Jarob, Dahm-Daphi, Jochen, Dikomey, Ekkehard

“…In mammalian cells repair of radiation-induced DNA damage appears to be also controlled by the epidermal growth factor receptor (EGFR) with a special impact on…”
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Radiosensitization of NSCLC cells by EGFR inhibition is the result of an enhanced p53-dependent G1 arrest by Kriegs, Malte, Gurtner, Kristin, Can, Yildiz, Brammer, Ingo, Rieckmann, Thorsten, Oertel, Reinhard, Wysocki, Marek, Dorniok, Franziska, Gal, Andreas, Grob, Tobias J, Laban, Simon, Kasten-Pisula, Ulla, Petersen, Cordula, Baumann, Michael, Krause, Mechthild, Dikomey, Ekkehard

“…Abstract Purpose How EGF receptor (EGFR) inhibition induces cellular radiosensitization and with that increase in tumor control is still a matter of…”
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Novel preclinical gastroenteropancreatic neuroendocrine neoplasia models demonstrate the feasibility of mutation-based targeted therapy by Viol, Fabrice, Sipos, Bence, Fahl, Martina, Clauditz, Till S., Amin, Tania, Kriegs, Malte, Nieser, Maike, Izbicki, Jakob R., Huber, Samuel, Lohse, Ansgar W., Schrader, Jörg

“…Purpose Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) form a rare and remarkably heterogeneous group of tumors. Therefore, establishing…”
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G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells by Cetin, Meryem H, Rieckmann, Thorsten, Hoffer, Konstantin, Riepen, Britta, Christiansen, Sabrina, Gatzemeier, Fruzsina, Feyerabend, Simon, Schoof, Melanie, Schüller, Ulrich, Petersen, Cordula, Mynarek, Martin, Rothkamm, Kai, Kriegs, Malte, Struve, Nina

“…The gene of the Epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), with deletions of exons 2-7…”
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A Lack of Effectiveness in the ATM-Orchestrated DNA Damage Response Contributes to the DNA Repair Defect of HPV-Positive Head and Neck Cancer Cells by Köcher, Sabrina, Zech, Henrike Barbara, Krug, Leonie, Gatzemeier, Fruzsina, Christiansen, Sabrina, Meyer, Felix, Rietow, Ruth, Struve, Nina, Mansour, Wael Yassin, Kriegs, Malte, Petersen, Cordula, Betz, Christian, Rothkamm, Kai, Rieckmann, Thorsten

“…Patients with human papillomavirus-positive squamous cell carcinoma of the head and neck (HPV+ HNSCC) have a favorable prognosis compared to those with…”
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Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells by Hintelmann, Katharina, Berenz, Thomas, Kriegs, Malte, Christiansen, Sabrina, Gatzemeier, Fruzsina, Struve, Nina, Petersen, Cordula, Betz, Christian, Rothkamm, Kai, Oetting, Agnes, Rieckmann, Thorsten

“…In head and neck squamous cell carcinoma (HNSCC), tumors positive for human papillomavirus (HPV) represent a distinct biological entity with favorable…”
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Analysis of the Plasticity of Circulating Tumor Cells Reveals Differentially Regulated Kinases During the Suspension‐to‐Adherent Transition by Smit, Daniel J., Hoffer, Konstantin, Bettin, Bettina, Kriegs, Malte, Cayrefourcq, Laure, Schumacher, Udo, Pantel, Klaus, Alix‐Panabières, Catherine, Jücker, Manfred

“…ABSTRACT Background Research on circulating tumor cells (CTCs) offers the opportunity to better understand the initial steps of blood‐borne metastasis as main…”
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