Search Results - "Krieglstein, Josef"

In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis by Fischer, Dagmar, Li, Youxin, Ahlemeyer, Barbara, Krieglstein, Josef, Kissel, Thomas

“…A comparative in vitro cytotoxicity study with different water-soluble, cationic macromolecules which have been described as gene delivery systems was…”
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Reversible phosphorylation of histidine residues in proteins from vertebrates by Klumpp, Susanne, Krieglstein, Josef

“…Signaling by kinases and phosphatases that act on serine, threonine, and tyrosine residues of proteins is among the most extensively studied regulatory…”
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A Dual Role for the SDF-1/CXCR4 Chemokine Receptor System in Adult Brain: Isoform-Selective Regulation of SDF-1 Expression Modulates CXCR4-Dependent Neuronal Plasticity and Cerebral Leukocyte Recruitment after Focal Ischemia by Stumm, Ralf K, Rummel, Jutta, Junker, Vera, Culmsee, Carsten, Pfeiffer, Manuela, Krieglstein, Josef, Hollt, Volker, Schulz, Stefan

“…The chemoattractant stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) are key modulators of immune function. In the…”
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Transforming Growth Factor-β1 Increases Bad Phosphorylation and Protects Neurons Against Damage by Zhu, Yuan, Yang, Guo-Yuan, Ahlemeyer, Barbara, Pang, Li, Che, Xiao-Ming, Culmsee, Carsten, Klumpp, Susanne, Krieglstein, Josef

“…Despite the characterization of neuroprotection by transforming growth factor-β1 (TGF-β1), the signaling pathway mediating its protective effect is unclear…”
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MALDI-TOF high mass calibration up to 200 kDa using human recombinant 16 kDa protein histidine phosphatase aggregates by Ludwig, Katrin, Habbach, Schähdi, Krieglstein, Josef, Klumpp, Susanne, König, Simone

“…Protein histidine phosphatase (PHP) is an enzyme which removes phosphate groups from histidine residues. It was described for vertebrates in the year 2002. The…”
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Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease by Zhu, Yuan, Hoell, Patrick, Ahlemeyer, Barbara, Sure, Ulrich, Bertalanffy, Helmut, Krieglstein, Josef

“…Oxidative stress plays crucial role in the pathogenesis of neurodegenerative diseases. However, the precise mechanism for an increased production of reactive…”
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Damage of Guinea Pig Heart and Arteries by a Trioleate-Enriched Diet and of Cultured Cardiomyocytes by Oleic Acid by Krieglstein, Josef, Kewitz, Tobias, Kirchhefer, Uwe, Hofnagel, Oliver, Weissen-Plenz, Gabriele, Reinbold, Michael, Klumpp, Susanne

“…Background: Mono-unsaturated fatty acids (MUFAs) like oleic acid have been shown to cause apoptosis of cultured endothelial cells by activating protein…”
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Retinoic acid reduces apoptosis and oxidative stress by preservation of SOD protein level by Ahlemeyer, Barbara, Bauerbach, Elke, Plath, Martina, Steuber, Mirjam, Heers, Cara, Tegtmeier, Frank, Krieglstein, Josef

“…Retinoic acid (RA) has already been shown to exert antiapoptotic and antioxidative activity in various cells. In this study, we determined the effect of RA on…”
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NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in d-2-hydroxyglutaric aciduria by Kölker, Stefan, Pawlak, Verena, Ahlemeyer, Barbara, Okun, Jürgen G., Hörster, Friederike, Mayatepek, Ertan, Krieglstein, Josef, Hoffmann, Georg F., Köhr, Georg

“…The inherited neurometabolic disease d‐2‐hydroxyglutaric aciduria is complicated by progressive neurodegeneration of vulnerable brain regions during infancy…”
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Upregulation of the Enzyme Chain Hydrolyzing Extracellular ATP after Transient Forebrain Ischemia in the Rat by Braun, Norbert, Zhu, Yuan, Krieglstein, Josef, Culmsee, Carsten, Zimmermann, Herbert

“…A short ischemic period induced by the transient occlusion of major brain arteries induces neuronal damage in selectively vulnerable regions of the…”
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Inhibition of serum deprivation- and staurosporine-induced neuronal apoptosis by Ginkgo biloba extract and some of its constituents by Ahlemeyer, Barbara, Möwes, Anja, Krieglstein, Josef

“…Previous studies have already demonstrated that some constituents of an extract of Ginkgo biloba (EGb), such as ginkgolide B and bilobalide, protect cultured…”
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Phosphorylation and dephosphorylation of histidine residues in proteins by Klumpp, Susanne, Krieglstein, Josef

“…Protein phosphorylation is a key mechanism for intracellular signal transduction in both prokaryotic and eukaryotic cells. Vertebrate proteins are prevalently…”
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Unsaturated fatty acids liberated from VLDL cause apoptosis in endothelial cells by Reinbold, Michael, Hufnagel, Birgit, Kewitz, Tobias, Klumpp, Susanne, Krieglstein, Josef

“…Certain unsaturated fatty acids (UFAs), cleaved from lipoproteins, are known to activate the serine/threonine protein phosphatase type 2C (PP2C) α- and…”
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ATP-binding on Fibroblast Growth Factor 2 Partially Overlaps with the Heparin-binding Domain by Rose, Karsten, Pallast, Stefanie, Klumpp, Susanne, Krieglstein, Josef

“…Fibroblast growth factor 2 (FGF2), an intensively studied heparin-binding cytokine, is an important modulator of cell growth and differentiation under both…”
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Ginkgolic acids induce neuronal death and activate protein phosphatase type-2C by Ahlemeyer, Barbara, Selke, Dagmar, Schaper, Christine, Klumpp, Susanne, Krieglstein, Josef

“…The standardized extract from Ginkgo biloba (EGb 761) is used for the treatment of dementia. Because of allergenic and genotoxic effects, ginkgolic acids are…”
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Enantio-selective effects of clenbuterol in cultured neurons and astrocytes, and in a mouse model of cerebral ischemia by Culmsee, Carsten, Junker, Vera, Thal, Serge, Kremers, Wolfram, Maier, Sandra, Schneider, Harald Jörn, Plesnila, Nikolaus, Krieglstein, Josef

“…Neuroprotective effects of the lipophilic β 2-adrenoceptor agonist clenbuterol have been established in neuronal cultures and in various rodent models of…”
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Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis by Culmsee, Carsten, Gerling, Norbert, Landshamer, Stefan, Rickerts, Bianca, Duchstein, Hans-Jürgen, Umezawa, Kazuo, Klumpp, Susanne, Krieglstein, Josef

“…Our previous results showed that inhibition of protein tyrosine phosphatases (PTP) by orthovanadate is an appropriate strategy to mimic nerve growth factor…”
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Acetylcholine content and viability of cholinergic neurons are influenced by the activity of protein histidine phosphatase by Eißing, Anna, Fischer, Daniel, Rauch, Ilka, Baumann, Anne, Schebb, Nils-Helge, Karst, Uwe, Rose, Karsten, Klumpp, Susanne, Krieglstein, Josef

“…The first mammalian protein histidine phosphatase (PHP) was discovered in the late 90s of the last century. One of the known substrates of PHP is ATP-citrate…”
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Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine-induced oxidative stress and apoptosis by Ahlemeyer, Barbara, Krieglstein, Josef

“…Cellular redox status is an important factor during neuronal apoptosis. In primary cultures of chick embryonic neurons, serum deprivation and treatment with…”
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Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage by Semkova, Irina, Wolz, Philipp, Schilling, Matthias, Krieglstein, Josef

“…It has been previously demonstrated that selegiline, an irreversible monoamine oxidase B (MAO-B) inhibitor, potentiates glial reaction to injury and possesses…”
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