Search Results - "Krieger, Charles"

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life by Rossi, Fabio M V, Ajami, Bahareh, Bennett, Jami L, Krieger, Charles, Tetzlaff, Wolfram

“…Microgliosis is a common response to multiple types of damage in the CNS. However, the origin of the cells involved in this process is still controversial and…”
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Making the connection - shared molecular machinery and evolutionary links underlie the formation and plasticity of occluding junctions and synapses by Harden, Nicholas, Wang, Simon Ji Hau, Krieger, Charles

“…The pleated septate junction (pSJ), an ancient structure for cell-cell contact in invertebrate epithelia, has protein components that are found in three…”
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Stress-mediated aggregation of disease-associated proteins in amyloid bodies by Chandhok, Sahil, Pereira, Lionel, Momchilova, Evgenia A., Marijan, Dane, Zapf, Richard, Lacroix, Emma, Kaur, Avneet, Keymanesh, Shayan, Krieger, Charles, Audas, Timothy E.

“…The formation of protein aggregates is a hallmark of many neurodegenerative diseases and systemic amyloidoses. These disorders are associated with the…”
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Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p by Stewart, Heather, Rutherford, Nicola J., Briemberg, Hannah, Krieger, Charles, Cashman, Neil, Fabros, Marife, Baker, Matt, Fok, Alice, DeJesus-Hernandez, Mariely, Eisen, Andrew, Rademakers, Rosa, Mackenzie, Ian R. A.

“…Two studies recently identified a GGGGCC hexanucleotide repeat expansion in a non-coding region of the chromosome 9 open-reading frame 72 gene ( C9ORF72 ) as…”
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Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS by Shan, Xiaoyang, Vocadlo, David, Krieger, Charles

“…Previous evidence demonstrates that TAR DNA binding protein (TDP-43) mislocalization is a key pathological feature of amyotrophic lateral sclerosis (ALS)…”
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Activity-dependent secretion of progranulin from synapses by Petoukhov, Eugenia, Fernando, Sarah, Mills, Fergil, Shivji, Farhan, Hunter, Diana, Krieger, Charles, Silverman, Michael A, Bamji, Shernaz X

“…The secreted growth factor progranulin (PGRN) has been shown to be important for regulating neuronal survival and outgrowth, as well as synapse formation and…”
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Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis by Rademakers, Rosa, Stewart, Heather, Dejesus-Hernandez, Mariely, Krieger, Charles, Graff-Radford, Neill, Fabros, Marife, Briemberg, Hannah, Cashman, Neil, Eisen, Andrew, Mackenzie, Ian R.A.

“…Mutations in the fused in sarcoma (FUS) gene have recently been found to cause familial amyotrophic lateral sclerosis (FALS). We screened FUS in a cohort of…”
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Homeodomain-interacting protein kinase (Hipk) plays roles in nervous system and muscle structure and function by Wang, Simon J H, Sinclair, Donald A R, Kim, Hae-Yoon, Kinsey, Stephen D, Yoo, Byoungjoo, Shih, Claire R Y, Wong, Kenneth K L, Krieger, Charles, Harden, Nicholas, Verheyen, Esther M

“…Homeodomain-interacting protein kinases (Hipks) have been previously associated with cell proliferation and cancer, however, their effects in the nervous…”
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20-hydroxyecdysone (20E) signaling regulates amnioserosa morphogenesis during Drosophila dorsal closure: EcR modulates gene expression in a complex with the AP-1 subunit, Jun by Yoo, Byoungjoo, Kim, Hae-Yoon, Chen, Xi, Shen, Weiping, Jang, Ji Sun, Stein, Shaianne N, Cormier, Olga, Pereira, Lionel, Shih, Claire R Y, Krieger, Charles, Reed, Bruce, Harden, Nicholas, Wang, Simon J H

“…Steroid hormones influence diverse biological processes throughout the animal life cycle, including metabolism, stress resistance, reproduction, and lifespan…”
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The Neuroinflammatory Response in ALS: The Roles of Microglia and T Cells by Lewis, Coral-Ann, Manning, John, Rossi, Fabio, Krieger, Charles

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by upper and lower motoneuron death. Mutations in the gene for…”
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Clinical and neuropathological features of ALS/FTD with TIA1 mutations by Hirsch-Reinshagen, Veronica, Pottier, Cyril, Nicholson, Alexandra M, Baker, Matt, Hsiung, Ging-Yuek R, Krieger, Charles, Sengdy, Pheth, Boylan, Kevin B, Dickson, Dennis W, Mesulam, Marsel, Weintraub, Sandra, Bigio, Eileen, Zinman, Lorne, Keith, Julia, Rogaeva, Ekaterina, Zivkovic, Sasha A, Lacomis, David, Taylor, J Paul, Rademakers, Rosa, Mackenzie, Ian R A

“…Mutations in the stress granule protein T-cell restricted intracellular antigen 1 (TIA1) were recently shown to cause amyotrophic lateral sclerosis (ALS) with…”
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Myelosuppressive conditioning using busulfan enables bone marrow cell accumulation in the spinal cord of a mouse model of amyotrophic lateral sclerosis by Lewis, Coral-Ann B, Manning, John, Barr, Christine, Peake, Kyle, Humphries, R Keith, Rossi, Fabio, Krieger, Charles

“…Myeloablative preconditioning using irradiation is the most commonly used technique to generate rodents having chimeric bone marrow, employed for the study of…”
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Bone Marrow-Derived Cell Accumulation in the Spinal Cord Is Independent of Peripheral Mobilization in a Mouse Model of Amyotrophic Lateral Sclerosis by Peake, Kyle, Manning, John, Lewis, Coral-Ann, Tran, Kevin, Rossi, Fabio, Krieger, Charles

“…Bone marrow-derived cells (BMDCs) are capable of migrating across the blood-brain barrier (BBB) and accumulating in the central nervous system (CNS) when…”
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Pilot study of granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS) by Cashman, Neil, Tan, Lih-Yeen, Krieger, Charles, Mädler, Burkhard, Mackay, Alex, Mackenzie, Ian, Benny, Barrett, Nantel, Stephen, Fabros, Marife, Shinobu, Leslie, Yousefi, Masoud, Eisen, Andrew

“…Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of upper and lower motor neurons in the brain, brainstem, and spinal cord. It has been…”
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Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis by Solomon, Jennifer N., Lewis, Coral-Ann B., Ajami, Bahareh, Corbel, Stephane Y., Rossi, Fabio M.V., Krieger, Charles

“…Amyotrophic lateral sclerosis (ALS) is associated with increased numbers of microglia within the central nervous system (CNS). However, it is unknown whether…”
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Imaging the Amyotrophic Lateral Sclerosis Brain: The Motor Band Sign by Krieger, Charles, Kalra, Sanjay

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Phospho-regulated Drosophila adducin is a determinant of synaptic plasticity in a complex with Dlg and PIP2 at the larval neuromuscular junction by Wang, Simon Ji Hau, Tsai, Amy, Wang, Mannan, Yoo, SooHyun, Kim, Hae-Yoon, Yoo, Byoungjoo, Chui, Vincent, Kisiel, Marta, Stewart, Bryan, Parkhouse, Wade, Harden, Nicholas, Krieger, Charles

“…Adducin is a ubiquitously expressed actin- and spectrin-binding protein involved in cytoskeleton organization, and is regulated through phosphorylation of the…”
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Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice by Peake, Kyle, Manning, John, Lewis, Coral-Ann, Barr, Christine, Rossi, Fabio, Krieger, Charles

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Ethical considerations in the management of amyotrophic lateral sclerosis by Eisen, Andrew, Krieger, Charles

“…This article examines some of the ethical concerns relevant for the management of amyotrophic lateral sclerosis (ALS). We emphasize the importance for…”
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Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool by Rossi, Fabio M V, Ajami, Bahareh, Bennett, Jami L, Krieger, Charles, McNagny, Kelly M

“…The authors examine the roles of microglia and blood-derived macrophages (which are morphologically indistinguishable) in experimental autoimmune encephalitis,…”
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